Differential Airway Inflammatory Responses in Asthma Exacerbations Induced by Respiratory Syncytial Virus and Influenza Virus A

Matsuse, Hiroto; Tsuchida, Tomoko; Fukahori, Susumu; Kawano, Tetsuya; Tomari, Shinya; Matsuo, Nobutake; Nishino, Tomoya; Kohno, Shigeru

doi:10.1159/000348381

Cited by 14 publications

(17 citation statements)

References 24 publications

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“…Influenza virus exacerbates asthma less frequently than rhinovirus (RV) and respiratory syncytial virus (RSV), but causes the most severe asthma exacerbations [5][6][7] . This is suggestive of virusspecific immune and inflammatory pathways that determine intensity and duration of an exacerbation 1,8,9 . Current understanding of these pathways in severe asthma exacerbations is fragmentary, which relates to the difficulty in obtaining sequential samples during a severe exacerbation.…”

Section: Accepted Articlementioning

confidence: 95%

An early innate response underlies severe influenza‐induced exacerbations of asthma in a novel steroid‐insensitive and anti‐IL‐5‐responsive mouse model

Ravanetti

Dijkhuis

Piñeros

et al. 2016

Allergy

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Section: Accepted Articlementioning

confidence: 95%

An early innate response underlies severe influenza‐induced exacerbations of asthma in a novel steroid‐insensitive and anti‐IL‐5‐responsive mouse model

Ravanetti

Dijkhuis

Piñeros

et al. 2016

Allergy

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“…Most deaths caused by asthma also occur in this age group [2,3]. Acute respiratory viral infections such as influenza are often the trigger for asthma attacks and therefore considered the primary culprits in the pathogenesis of asthma in the elderly [4,5].…”

Section: Introductionmentioning

confidence: 99%

Dendritic Cells from Aged Subjects Display Enhanced Inflammatory Responses toChlamydophila pneumoniae

Prakash

Agrawal

et al. 2014

Mediators of Inflammation

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Chlamydophila pneumoniae (CPn) is a common respiratory pathogen that causes a chronic and persistent airway infection. The elderly display an increased susceptibility and severity to this infection. However, the underlying mechanisms are not well understood. Dendritic cells (DCs) are the initiators and regulators of immune responses. Therefore, we investigated the role of DCs in the age-associated increased CPn infection in vitro in humans. Though the expression of activation markers was comparable between the two age groups, DCs from aged subjects secreted enhanced levels of proinflammatory mediators such as TNF-α and CXCL-10 in response to CPn. In contrast, the secretion of IL-10 and innate interferons, IFN-α and IFN-λ, was severely impaired in DCs from aged donors. The increased activation of DCs from aged subjects to CPn also resulted in enhanced proliferation of CD4 and CD8 T cells in a DC-T coculture. Furthermore, T cells primed with CPn-stimulated DCs from aged subjects secreted increased levels of IFN-γ and reduced levels of IL-10 compared to DCs obtained from young subjects. In summary, DCs from the elderly displayed enhanced inflammatory response to CPn which may result in airway remodeling and increase the susceptibility of the elderly to respiratory diseases such as asthma.

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“…In that sense, antiviral immune responses, prominently driven by CD8 + T cells and macrophages, might critically influence allergic lung diseases [294]. However, it is also clear by now that the inflammatory response varies depending on the causative agents for viral respiratory infections and might thus differentially influence exacerbations of allergic asthma [295]. …”

Section: T Cell Model Systems For Allergy Researchmentioning

confidence: 99%

Lymphocyte-Based Model Systems for Allergy Research: A Historic Overview

Neunkirchner

Schmetterer

Pickl

2014

Int Arch Allergy Immunol

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During the last decades, a multitude of studies applying distinct in vitro and in vivo model systems have contributed greatly to our better understanding of the initiation and regulation of inflammatory processes leading to allergic diseases. Over the years, it has become evident that among lymphocytes, not only IgE-producing B cells and allergy-orchestrating CD4⁺ helper cells but also cytotoxic CD8⁺ T cells, γδ-T cells and innate lymphoid cells, as well as regulatory lymphocytes, might critically shape the immune response towards usually innocuous allergens. In this review, we provide a historic overview of pioneering work leading to the establishment of important lymphocyte-based model systems for allergy research. Moreover, we contrast the original findings with our currently more refined knowledge to appreciate the actual validity of the respective models and to reassess the conclusions obtained from them. Conflicting studies and interpretations are identified and discussed. The tables are intended to provide an easy overview of the field not only for scientists newly entering the field but also for the broader readership interested in updating their knowledge. Along those lines, herein we discuss in vitro and in vivo approaches to the investigation of lymphocyte effector cell activation, polarization and regulation, and describe depletion and adoptive transfer models along with gene knockout and transgenic (tg) methodologies. In addition, novel attempts to establish humanized T cell antigen receptor tg mouse models for allergy research are described and discussed.

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Differential Airway Inflammatory Responses in Asthma Exacerbations Induced by Respiratory Syncytial Virus and Influenza Virus A

Cited by 14 publications

References 24 publications

An early innate response underlies severe influenza‐induced exacerbations of asthma in a novel steroid‐insensitive and anti‐IL‐5‐responsive mouse model

An early innate response underlies severe influenza‐induced exacerbations of asthma in a novel steroid‐insensitive and anti‐IL‐5‐responsive mouse model

Dendritic Cells from Aged Subjects Display Enhanced Inflammatory Responses toChlamydophila pneumoniae

Lymphocyte-Based Model Systems for Allergy Research: A Historic Overview

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