Differential Agglutination Titre (D.A.T.) in Juvenile Rheumatoid Arthritis

Bywaters, E. G. L.; Carter, Mary E.; Scott, F. E. T.

doi:10.1136/ard.18.3.225

Cited by 34 publications

(4 citation statements)

References 3 publications

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“…All stored sera had been frozen at -70°C prior to study. At the time study sera were obtained patients also had complete physical and ophthalmologic examinations, standard laboratory tests (complete blood counts, sedimentation rates, tests for rheumatoid factor by latex agglutination and differential agglutination tests (12), serum immunoglobulins by radial diffusion in agar (13)), and radiographs of the sacroiliac joints. At the time of study the mean disease duration of the disease for patients with iridocyclitis was 12.9 years (median 11 years, range 1 to 34 years), and most patients were between 11 and 30 years of age (mean age 17.4 years, median age 16 years, range 4-37 years.…”

Section: Methodsmentioning

confidence: 99%

The association of antinuclear antibodies with the chronic iridocyclitis of juvenile rheumatoid arthritis (Still's disease)

Schaller

Johnson

Holborow

et al. 1974

Arthritis & Rheumatism

134

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Positive tests for antinuclear antibodies (ANA) were found in 51 of 58 (88%) patients with chronic iridocyclitis and juvenile rheumatoid arthritis (Still's disease). Antinuclear antibodies were predominantly of the IgG class of immunoglobulins and were generally present in titers of 1 5 0 (six ANA units) or more. They were unassociated with disease activity, severity or duration, age of patient at onset or testing, or sex. Neither other autoantibodies nor antibodies reactive with DNA or RNA were associated. In 8 patients tested early in disease, ANA were found prior to the onset of iridocyclitis. The presence of ANA should prove useful in identifying patients with JRA at risk for chronic iridocyclitis. In contrast, negative tests for ANA in patients with childhood-onset arthritis and iridocyclitis were found to be associated with acute iridocyclitis and subsequent ankylosing spondylitis.Iridocyclitis, inflammation of the iris and ciliary body, affects about 10% of children with juvenile rheumatoid arthritis (JRA,

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Section: Methodsmentioning

confidence: 99%

The association of antinuclear antibodies with the chronic iridocyclitis of juvenile rheumatoid arthritis (Still's disease)

Schaller

Johnson

Holborow

et al. 1974

Arthritis & Rheumatism

134

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“…of Still's disease patients compared with 70 to 80 per cent. of affected adults (Bywaters, Carter, and Scott, 1959;Laaksonen, 1966). Similarly, using the sensitive agglutination test with human FII coated erythrocytes, only 26 per cent.…”

mentioning

confidence: 99%

Raised IgG antiglobulin factors in Still's disease.

Torrigiani¹,

Ansell²,

Chown³

et al. 1969

Annals of the Rheumatic Diseases

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“…Juvenile rheumatoid arthritis (JRA) differs in many aspects from its adult counterpart (Edstrom, 1958); one of the differences is a low incidence of positive sero-reactions for rheumatoid factors (RF) in patients with JRA (Bywaters, Carter, and Scott, 1959;Sievers, Ahvonen, Aho, and Wager, 1963;Ansell, 1966). Although the agglutinating activity of RF was found in different classes of immunoglobulins (IgC, IgA, IgM), the typical representative of RF is IgM (McCormick, 1966).…”

mentioning

confidence: 99%