Differential Acute Impacts of Sleeve Gastrectomy, Roux-en-Y Gastric Bypass Surgery and Matched Caloric Restriction Diet on Insulin Secretion, Insulin Effectiveness and Non-Esterified Fatty Acid Levels Among Patients with Type 2 Diabetes

Thomas, Felicity; Smith, Greg; Lu, Jun; Babor, Richard; Booth, Michael; Beban, Grant; Chase, J. Geoffrey; Murphy, Rinki

doi:10.1007/s11695-015-2038-3

Cited by 17 publications

(12 citation statements)

References 34 publications

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“…Therefore, in our case, although LSG improved insulin resistance along with decreasing fat areas and improving glycemic metabolism, insulin secretion remained higher, especially in the early phase after the glucose load. This clinical feature is different from that of the patients with primary obesity in whom insulin hypersecretion is ameliorated with weight reduction after LSG (Nannipieri et al 2013;Thomas et al 2016). Because LSG increased GLP-1 (Ionut et al 2013) that enhances insulin secretion after diet (Koliaki and Doupis 2011), it is possible that, in our case, LSG could further enhance insulin secretion, although insulin hypersecretion state already existed.…”

Section: Discussioncontrasting

confidence: 54%

Laparoscopic Sleeve Gastrectomy on Severe Obesity after Intracranial Germinoma Treatment: A Case Report

Nezu

Kudo

Ono

et al. 2019

Tohoku J. Exp. Med.

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Hypothalamic obesity is a clinical syndrome characterized by severe and refractory obesity that is caused by hypothalamic function impairment. Recently, bariatric surgery has been attempted for patients with hypothalamic obesity after craniopharyngioma, but experiences have not yet been accumulated in other hypothalamic disorders. Here, we report the case of a 39-year-old male patient with panhypopituitarism who received laparoscopic sleeve gastrectomy (LSG) after intracranial germinoma treatment. The patient was diagnosed with intracranial germinoma at age 15 and achieved complete remission after radiotherapy (total 50 Gy). He was obese during diagnosis [body mass index (BMI), 29.2 kg/m 2 ], and his obesity gradually worsened after the intracranial germinoma treatment, and LSG was considered when his BMI was 48.6 kg/m 2. After 1 month of hospitalized diet-exercise program, LSG was performed. After LSG, his BMI gradually decreased and reached 38.8 kg/m 2 on the day of discharge (6 weeks after the surgery). Five months after LSG, his insulin resistance improved, but insulin hypersecretion remained. Fifteen months after the surgery, his BMI was 31.2 kg/m 2 , with marked decrease in visceral and subcutaneous fat areas (from 393.8 cm 2 and 168.2 cm 2 before the surgery to 111.5 cm 2 and 56.3 cm 2 , respectively.). To our knowledge, this is the first case of LSG for hypothalamic obesity after intracranial germinoma treatment. Although the pathophysiology of hypothalamic obesity is different from that of primary obesity, LSG could be a successful therapeutic choice for patients with hypothalamic obesity after the intracranial germinoma treatment.

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Section: Discussioncontrasting

confidence: 54%

Laparoscopic Sleeve Gastrectomy on Severe Obesity after Intracranial Germinoma Treatment: A Case Report

Nezu

Kudo

Ono

et al. 2019

Tohoku J. Exp. Med.

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“…We selected part of papers to compare the results from different regions of the world. The outcomes of studies from Asia, [9,10] Europe, [11] North America, [8] South America [4] and Oceania [12] are listed in Table 4. We found no studies from Africa.…”

Section: Discussionmentioning

confidence: 99%

Laparoscopic sleeve gastrectomy versus Roux-en-Y gastric bypass for morbid obesity: a 1:1 matched cohort study in a Chinese population

Zhang

Zhou

et al. 2016

Oncotarget

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ObjectivesThis 1:1 matched cohort study with 3-year follow-up aimed to compare the safety and efficacy of LSG with LRYGB for morbid obesity patients.MethodsFrom 2009 to 2013, patients undergoing LRYGB (n = 63) were matched with LSG (n = 63) by gender, age, and body mass index (BMI). Major complications, BMI, percentage of excess weight loss (%EWL), and obesity-related comorbidities after 6, 12, 24, and 36 months were compared.ResultsHospital stay and major complication rates were comparable, but operative time in LSG was significantly shorter (83.2 ± 23.7 vs. 108.3 ± 21.3 min). No significant differences in mean %EWL and BMI were observed at 6, 12, 24 months. At 3-year follow-up, mean %EWL in the LRYGB group was significantly higher than in the LSG group (76.5 ± 9.2% vs. 65.7 ± 10.3%) and, consequently, mean BMI was significantly lower in LRYGB (28.2 ± 1.5 vs. 30.9 ± 2.4 kg/m2). No significant differences in remission of comorbidities were observed at 1- or 3-year follow-up.ConclusionsBoth LRYGB and LSG were safe and effective bariatric procedures in this Chinese population, but LRYGB seemed to be superior to LSG in terms of mid-term weight loss.

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“…In all three groups, palmitic acid, stearic acid, linoleic acid, DGLA, and EPA decreased after surgery, while oleic acid, arachidonic acid, and DHA levels stayed unchanged. No significant difference for oleic acid has previously been demonstrated 3 days after RYGB in two other studies that at the same time found significant decreases in both palmitic acid, stearic acid, and linoleic acid (Nemati et al, 2017; Thomas et al, 2016).…”

Section: Discussionmentioning

confidence: 83%

Fractionated free fatty acids and their relation to diabetes status after Roux‐en‐Y gastric bypass: A cohort study

et al. 2021

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Differential Acute Impacts of Sleeve Gastrectomy, Roux-en-Y Gastric Bypass Surgery and Matched Caloric Restriction Diet on Insulin Secretion, Insulin Effectiveness and Non-Esterified Fatty Acid Levels Among Patients with Type 2 Diabetes

Abstract: Background:

Cited by 17 publications

References 34 publications

Laparoscopic Sleeve Gastrectomy on Severe Obesity after Intracranial Germinoma Treatment: A Case Report

Laparoscopic Sleeve Gastrectomy on Severe Obesity after Intracranial Germinoma Treatment: A Case Report

Laparoscopic sleeve gastrectomy versus Roux-en-Y gastric bypass for morbid obesity: a 1:1 matched cohort study in a Chinese population

Fractionated free fatty acids and their relation to diabetes status after Roux‐en‐Y gastric bypass: A cohort study

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