Differential accumulation and release of long-chain &lt;I&gt;n&lt;/I&gt;–3 fatty acids from liver, muscle, and adipose tissue triacylglycerols

Herzberg, Gene R.; Skinner, C

doi:10.1139/cjpp-75-8-945

Cited by 14 publications

(9 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This could explain why the major proportion of fatty acids is transported to the muscles. When the levels of triaglycerols are lowered, long-chain n-3 fatty acids are released by the muscles [24]. This corresponds well with the observation that the n-3 fatty acids, docosahexaenoic acid, were found to be released by the muscles.…”

Section: Discussionsupporting

confidence: 74%

Multi-Organ Contribution to the Metabolic Plasma Profile Using Hierarchical Modelling

et al. 2015

View full text Add to dashboard Cite

Hierarchical modelling was applied in order to identify the organs that contribute to the levels of metabolites in plasma. Plasma and organ samples from gut, kidney, liver, muscle and pancreas were obtained from mice. The samples were analysed using gas chromatography time-of-flight mass spectrometry (GC TOF-MS) at the Swedish Metabolomics centre, Umeå University, Sweden. The multivariate analysis was performed by means of principal component analysis (PCA) and orthogonal projections to latent structures (OPLS). The main goal of this study was to investigate how each organ contributes to the metabolic plasma profile. This was performed using hierarchical modelling. Each organ was found to have a unique metabolic profile. The hierarchical modelling showed that the gut, kidney and liver demonstrated the greatest contribution to the metabolic pattern of plasma. For example, we found that metabolites were absorbed in the gut and transported to the plasma. The kidneys excrete branched chain amino acids (BCAAs) and fatty acids are transported in the plasma to the muscles and liver. Lactic acid was also found to be transported from the pancreas to plasma. The results indicated that hierarchical modelling can be utilized to identify the organ contribution of unknown metabolites to the metabolic profile of plasma.

show abstract

Section: Discussionsupporting

confidence: 74%

Multi-Organ Contribution to the Metabolic Plasma Profile Using Hierarchical Modelling

et al. 2015

View full text Add to dashboard Cite

show abstract

“…70 % of AT mass is formed by lipids [110]. Similar to liver and skeletal muscle, the fatty acid composition in AT triacylglycerols approximately corresponds to the composition of fatty acids in the diet [111]. Importantly, in addition to the storage of DHA in AT, a substantial portion of DHA is contained in brain phospholipids.…”

Section: Accumulation and Storage Of N−3 Lc-pufas In Watmentioning

confidence: 97%

Cellular and molecular effects ofn−3 polyunsaturated fatty acids on adipose tissue biology and metabolism

Flachs

Rossmeisl

Bryhn³

et al. 2008

Clinical Science

257

193

View full text Add to dashboard Cite

Adipose tissue and its secreted products, adipokines, have a major role in the development of obesity-associated metabolic derangements including Type 2 diabetes. Conversely, obesity and its metabolic sequelae may be counteracted by modulating metabolism and secretory functions of adipose tissue. LC-PUFAs (long-chain polyunsaturated fatty acids) of the n-3 series, namely DHA (docosahexaenoic acid; C(22:6n-3)) and EPA (eicosapentaenoic acid; C(20:5n-3)), exert numerous beneficial effects, such as improvements in lipid metabolism and prevention of obesity and diabetes, which partially result from the metabolic action of n-3 LC-PUFAs in adipose tissue. Recent studies highlight the importance of mitochondria in adipose tissue for the maintenance of systemic insulin sensitivity. For instance, both n-3 LC-PUFAs and the antidiabetic drugs TZDs (thiazolidinediones) induce mitochondrial biogenesis and beta-oxidation. The activation of this 'metabolic switch' in adipocytes leads to a decrease in adiposity. Both n-3 LC-PUFAs and TZDs ameliorate a low-grade inflammation of adipose tissue associated with obesity and induce changes in the pattern of secreted adipokines, resulting in improved systemic insulin sensitivity. In contrast with TZDs, which act as agonists of PPARgamma (peroxisome-proliferator-activated receptor-gamma) and promote differentiation of adipocytes and adipose tissue growth, n-3 LC-PUFAs affect fat cells by different mechanisms, including the transcription factors PPARalpha and PPARdelta. Some of the effects of n-3 LC-PUFAs on adipose tissue depend on their active metabolites, especially eicosanoids. Thus treatments affecting adipose tissue by multiple mechanisms, such as combining n-3 LC-PUFAs with either caloric restriction or antidiabetic/anti-obesity drugs, should be explored.

show abstract

“…The steps of FA accumulation have been previously investigated in laboratory animals and humans [36,[41][42][43][44][45][46][47][48] but rarely in seasonal mammals. In the captive alpine marmot (Marmota marmota) the FA composition of the sc and gonadal WAT did not change in spite of hibernation and the subsequent refeeding period with fat accumulation [49].…”

Section: Selective Incorporation Of Fa Into the Sc Adipose Tissuementioning

confidence: 99%

Selective Seasonal Fatty Acid Accumulation and Mobilization in the Wild Raccoon Dog (Nyctereutes procyonoides)

Mustonen

Asikainen

Aho

et al. 2007

Lipids

View full text Add to dashboard Cite

Previous studies on laboratory rodents, rabbits and humans have demonstrated that fatty acid (FA) mobilization from white adipose tissue (WAT) is selective and its efficiency is related to FA structure. Selective FA mobilization was also documented in a carnivore, the farmed raccoon dog (Nyctereutes procyonoides), fasted for 8 weeks. The present study explored whether similar selectivity of FA mobilization was manifested in wild mammals experiencing seasonal food scarcity and abundance. Fractional mobilization from and incorporation into WAT of a wide spectrum of FA were studied by gas-liquid chromatography from the subcutaneous WAT of free-ranging raccoon dogs with the same individuals sampled in consecutive seasons. The wintertime FA mobilization was selective and mostly confirmed the patterns of FA release in captivity. Mobilization correlated inversely with the FA chain length but increased with unsaturation and when the first double bond was located closer to the methyl end. 18-20 C n-3 polyunsaturated FA (PUFA) and 14-17 C monounsaturated FA (MUFA) were preferentially mobilized while 19-24 C saturated FA and MUFA were preserved during wintering. The summertime FA incorporation correlated inversely with the chain length and increased with unsaturation and in MUFA and PUFA with double bonds closer to the methyl end. The principles of selective FA mobilization were valid in wild mammals. FA incorporation was also selective and reversed the wintertime losses of the preferably mobilized FA.

show abstract

Differential accumulation and release of long-chain <I>n</I>–3 fatty acids from liver, muscle, and adipose tissue triacylglycerols

Cited by 14 publications

References 18 publications

Multi-Organ Contribution to the Metabolic Plasma Profile Using Hierarchical Modelling

Multi-Organ Contribution to the Metabolic Plasma Profile Using Hierarchical Modelling

Cellular and molecular effects ofn−3 polyunsaturated fatty acids on adipose tissue biology and metabolism

Selective Seasonal Fatty Acid Accumulation and Mobilization in the Wild Raccoon Dog (Nyctereutes procyonoides)

Contact Info

Product

Resources

About