Different Variants of Carbohydrate Metabolism Disorder and Its Influence on Myocardial Infarction Course

Abstract

Altogether 360 patients (63.4 % of men) were examined with the aim to reveal the incidence of carbohydrate metabolism disorder and evaluate its influence on the course of myocardial infarction. Of the 292 patients without known diabetes mellitus (DM) type 2 — 31.8 % had prediabetes, and 11.0 % had newly diagnosed DM type 2. Patients with carbohydrate metabolism disorder more often had acute heart failure (AHF Killip II-IV) (40.6 % of patients with normal glycaemia, 55.9 % with prediabetes, 62.6 % and 64.7 % with newly diagnosed and known DM, р = 0.039), and more apparent chronic heart failure (NYHA III-IV) (in 4.2; 9.4; 16.0 and 24.6 % respectively, р < 0.001). Twenty four-hour mortality was higher in patients with known DM type 2 than those without DM (13.2 and 2.3 %, р = 0.008). Regression analysis revealed that impaired glucose metabolism was associated with AHF (Killip II—III (OR = 1.27; 95 % CI: 1.05—1,.54, р = 0.014), Killip IV (OR = 1.39; 95 % CI: 1.06—1.82, р = 0.016)); DM type 2 was associated with higher rate of in-hospital mortality (OR = 4.71; 95 % CI: 2.27—9.78, р < 0.001).

Predictors of Carbohydrate Metabolism Disorders and Lethal Outcome in Patients after Myocardial Infarction: A Place of Glucose Level

“…CMDs worsen the course of AMI. The authors of [ 23 ] described various CMDs influenced the course of AMI: patients with prediabetes were characterized by multivessel coronary disease and the more frequent development of acute and chronic heart failure in AMI compared with patients without CMDs; patients with newly diagnosed DM type 2 were characterized by adverse early prognosis for myocardial infarction. Prediabetes worsens systolic functions and left ventricle diastolic parameters [ 24 ].…”