Different Types of Wounds

Vachhrajani, Vibhakar; Khakhkhar, Payal

doi:10.1007/978-981-32-9236-9_13

Cited by 4 publications

(3 citation statements)

References 36 publications

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“…According to the definition, a wound is an anatomical interruption of the continuity of external layers (skin, mucous membrane) and deeper tissues under the influence of a damaging physical, chemical, or biological factor [32]. The classic characteristics of a wound include pain, bleeding, and dripping [33].…”

Section: Wounds: Pathophysiology Classification Therapeutic Approachesmentioning

confidence: 99%

Alginate-Based Materials Loaded with Nanoparticles in Wound Healing

et al. 2023

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Alginate is a naturally derived polysaccharide widely applied in drug delivery, as well as regenerative medicine, tissue engineering and wound care. Due to its excellent biocompatibility, low toxicity, and the ability to absorb a high amount of exudate, it is widely used in modern wound dressings. Numerous studies indicate that alginate applied in wound care can be enhanced with the incorporation of nanoparticles, revealing additional properties beneficial in the healing process. Among the most extensively explored materials, composite dressings with alginate loaded with antimicrobial inorganic nanoparticles can be mentioned. However, other types of nanoparticles with antibiotics, growth factors, and other active ingredients are also investigated. This review article focuses on the most recent findings regarding novel alginate-based materials loaded with nanoparticles and their applicability as wound dressings, with special attention paid to the materials of potential use in the treatment of chronic wounds.

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Section: Wounds: Pathophysiology Classification Therapeutic Approachesmentioning

confidence: 99%

Alginate-Based Materials Loaded with Nanoparticles in Wound Healing

et al. 2023

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“…Based on their etiology, wounds can be divided widely into acute and chronic wounds. Acute wounds are most often caused by conditions such as trauma or burns (Vachhrajani & Khakhkhar, 2019). Acute wounds, if the proper care is required, can usually recover in a short time.…”

Section: Introductionmentioning

confidence: 99%

“…Acute wounds, if the proper care is required, can usually recover in a short time. In wound healing, quick and full wound healing is often necessary as the resulting scar tissue would be more satisfactory (Vachhrajani & Khakhkhar, 2019). An infected wound is a deformity or excavation of localized skin during which pathogenic organisms have invaded into viable tissue surrounding the laceration (Everts, 2018).…”

Section: Introductionmentioning

confidence: 99%

Synergic antibacterial activity of honey-garlic versus honey-ginger on Pseudomonas aeruginosa and Klebsiella pneumoniae isolated from acute wound infection in Guyana, South America

Allen¹,

Daniel²,

Liverpool³

et al. 2023

GSC Biol. Pharm. Sci.

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This study compared the antibacterial activity of honey-garlic and honey-ginger mixtures against two clinically important bacteria frequently implicated in acute wound infections; Pseudomonas aeruginosa and Klebsiella pneumoniae. Individual extracts of honey, ginger, garlic and erythromycin antibiotics (positive control), were also tested. Concentrations of 100%, 75%, 50%, and 25% of the natural extracts and mixtures were prepared by the use of sterilized distilled water as the solvent. The antibacterial activity of each natural extract and the antibiotic was tested against the aforementioned bacterial species at different concentrations using the disc diffusion method. Further, MIC and MBC tests were conducted on each natural mixture using the broth dilution method and spread plate method, respectively. Our results showed garlic exhibited the highest antibacterial activity against both bacteria at 100% concentration, whereas honey and ginger showed the lowest antibacterial activity against Klebsiella pneumoniae and Pseudomonas aeruginosa, respectively at 25% concentrations. Honey-garlic mixture was the most effective against Klebsiella pneumoniae, whereas honey-ginger mixture was the most effective against Pseudomonas aeruginosa. The antibiotic was more effective than the natural mixtures against Pseudomonas aeruginosa, but not so effective against Klebsiella pneumoniae. The MIC of both mixtures against Pseudomonas aeruginosa ranged from 25%-50%, while it ranged from 6%-50% for Klebsiella pneumoniae. Honey-garlic was the only mixture against Klebsiella pneumoniae that exhibited bactericidal effects at 50% (MBC).

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