Different types of small nerve fibers in eutopic endometrium and myometrium in women with endometriosis

Tokushige, Natsuko; Markham, Robert; Russell, Peter; Fraser, Ian S.

doi:10.1016/j.fertnstert.2006.12.078

Cited by 114 publications

(89 citation statements)

References 64 publications

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“…These results suggest that, under the influence of estrogen, the endometrial stroma produces inhibitory signals for sympathetic nerves, whereas epithelial basal laminas retain their ability to support neuritic growth. The relatively recent finding of an abnormal presence of sympathetic and other nerves in eutopic endometrium and ectopic endometriotic growths in women with endometriosis (Tokushige et al 2006(Tokushige et al , 2007 and in ectopic cysts of rats with experimental endometriosis (Berkley et al 2004(Berkley et al , 2007 have increased the relevance of understanding in detail the mechanisms regulating the innervation of the endometrium and its responses to estrogen. Recent studies have demonstrated that increased levels of NGF and other trophic molecules contribute to the abnormal innervation observed in eutopic endometrium and ectopic endometriotic growths in women with endometriosis (Anaf et al 2002;Tokushige et al 2006).…”

Section: Substrate-bound Signals Contributes To Histotypic Patterningmentioning

confidence: 99%

Reduced sympathetic neurite outgrowth on uterine tissue sections from rats treated with estrogen

et al. 2010

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In order to evaluate the contribution of substrate-bound factors to the extent and patterning of the sympathetic innervation of rat uterus following estrogen treatment, superior cervical ganglion explants from neonatal and adult ovariectomized rats were cultured on tissue sections of fresh frozen uterus from adult ovariectomized rats treated with estrogen or a vehicle. The main findings were: (1) neurite growth was greatly influenced by histological features of the underlying section; (2) on myometrial sections, neurites followed the orientation of the main axis of the longitudinally sectioned muscle cells; (3) neurites showed limited growth on transversally sectioned smooth muscle; (4) neuritic patterning was unaffected by a reduction in migrating ganglionic non-neuronal cells; (5) neurite outgrowth, but not non-neural cell migration, was markedly reduced on myometrial sections from rats treated with estrogen. These results suggest that adult myometrium continues to provide signals allowing the organotypic patterning and growth of sympathetic axons, that estrogen treatment modifies myometrial substrate properties so that it is less supportive for sympathetic neurite growth, and that adult sympathetic neurons retain their ability to recognize substrate-bound cues present in the myometrium. On endometrial sections, neurites formed radially symmetric halos, which were reduced in size on estrogen-treated endometrial substrates. Thus, changes in the neuritogenic capacity of the uterus underlie plasticity in uterine sympathetic nerves, and alterations in substrate-bound factors contribute to the diminished receptivity of the estrogenized uterus to its sympathetic innervation.

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Section: Substrate-bound Signals Contributes To Histotypic Patterningmentioning

confidence: 99%

Reduced sympathetic neurite outgrowth on uterine tissue sections from rats treated with estrogen

et al. 2010

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“…Die Dichte der PGP-9.5-positiven Nervenfasern in der Funktionalis und Basalis war in der sekretorischen Phase höher als in der prolifera- Nervenfasern. (Nach [28,32] …”

Section: Differenzierung Der Nervenfasernunclassified

Endometriose und Nervenfasern

et al. 2010

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“…De même, l'expression de neurotransmetteurs et de protéines tels que le TGFß, la substance P, le récepteur du NGF, TrKA et P75 a été décrite [4,56,74,78]. L'expression du TGFß est corrélée à la sévérité de la douleur [74].…”

Section: Lé Sions Endomé Trisiquesunclassified

“…De plus, de nombreuses données suggèrent que l'endomètre lui-même puisse avoir un rôle dans les signes douloureux de ces patientes [50,77,78]. Depuis de nombreuses années, on suppose que les prostaglandines sont impliquées dans la dysménorrhée associée à l'endométriose [14,39].…”

Section: Endomè Tre Des Patientes Atteintes D'endomé Trioseunclassified

Endometriosis and pain

et al. 2007

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L'endométriose est une maladie bénigne, très invalidante et fréquente, définie par la présence d'endomètre, épithélium et stroma, en situation ectopique. Sa physiopathologie, et celle des douleurs qui l'accompagnent, est mal connue. Les signes cliniques de cette pathologie hormonodépendante sont dysménorrhée, dyspareunie et douleur chronique. On distingue deux grands types d'endométriose : l'endométriose superficielle ou minime et les formes sévères ou infiltrantes. Même s'il n'existe pas de parallélisme anatomoclinique, on sait que les lésions infiltrantes sont plus souvent à l'origine de dyspareunie, de troubles digestifs ou urinaires associés. Le traitement est soit un traitement médical qui stoppe la maladie en induisant une aménorrhée, soit un traitement chirurgical qui consiste en une destruction ou une excision des lésions. Ce traitement chirurgical est le plus souvent réalisé par coelioscopie. Les indications respectives de ces deux traitements dépendent du type de lésion et des circonstances diagnostiques et cliniques.Abstract: Endometriosis is a benign disease, very incapacitating and common disease that is characterised by the endometrium, epithelium and stroma existing in an ectopic presentation. The physiopathology of this disease and its associated pain is not well known. The clinical symptoms of this hormone-dependent disease are dysmenorrhea, dyspareunia and chronic pain. There are two main types of endometriosis: superficial endometriosis and more severe forms of endometriosis. Although there are no anatomical and clinical similarities, deep lesions very often cause dyspareunia, and associated digestive or urinary disorders. Treatment is either medical, which stops the disease by inducing amenorrhea; or surgical, which involves destroying or excising the lesions. Surgery is most commonly done by laparoscopy. The respective indications for these two types of treatment depend on the lesion type and the diagnostic and clinical circumstances.

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Different types of small nerve fibers in eutopic endometrium and myometrium in women with endometriosis

Cited by 114 publications

References 64 publications

Reduced sympathetic neurite outgrowth on uterine tissue sections from rats treated with estrogen

Reduced sympathetic neurite outgrowth on uterine tissue sections from rats treated with estrogen

Endometriose und Nervenfasern

Endometriosis and pain

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