Different types of hyperammonemia in clinical practice

Плотникова, Е. Ю.; Сухих, А. С.

doi:10.21518/2079-701x-2018-14-34-42

Cited by 7 publications

(3 citation statements)

References 60 publications

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“…System ammonium is a side product of urea, glutamine and alanine exchanges. Significant accumulations of non-system free ammonium lead to urea synthesis acceleration and the latter can take participation to complexformation with proteins and other polymers [12]. Due to the aforementioned processes, according to our data, possibly the ornithine cycle is activated, which particularly is expressed by arginase IA activity increasing.…”

Section: Methodssupporting

confidence: 51%

“…4). It was pronounced that the expression level of Arg IA was enhanced which is connected with ureagenesis stimulation and possibly results from oxidative stress emerged due to vibration [12]. Arg IB was repressed.…”

Section: Methodsmentioning

confidence: 98%

“…This stimulates mobilization of organism adaptation possibilities. During the intensive effects of stress factors, pronounced changes of protein metabolism occur, moreover, the revealed changes do not have to be directly connected to the acting factor, but they are only a result of non-specific adaptation mechanisms [12].…”

Section: Methodsmentioning

confidence: 99%

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Effect of Vibration Stress Both on the Shifts of Soluble Protein Fractions From Rat Liver and on the Arginase I Activity

Barseghyan

Karapetyan

Trchоunian³

2021

Proc. YSU B: Chem. Biol. Sci.

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Vibration pathology is in the second place among diseases connected to the profession. The vibration effect both on the protein fraction shifts and on the activities of I type arginase (Arg) IA and IB from white rat liver has been studied in the conditions of 5-, 10- and 15-day vibration state. In the initial state of vibration some decrease of Arg IA and Arg IB activities was revealed as compared to the control without general protein spectrum change of liver extract. Along with vibration effect, the expression level of Arg IA was increased with duration enhancement, which possibly is due to hyperammonemia, in the result of which ureagenesis is stimulated. Stimulation of easy available adaptation reserves were described due to protein catabolism. Analysis of shifts of general and enzyme protein fractions in the conditions of vibration effect allows to reveal their qualitative and quantitative changes and to make important the organism adaptation reactions that result from anabolic and catabolic process relations. It is possible that the revealed changes in the activity of arginase IA and IB are a biologically expedient mechanism for regulating the activity of hepatic arginase during vibration stress.

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Section: Methodssupporting

confidence: 51%

Section: Methodsmentioning

confidence: 98%

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Effect of Vibration Stress Both on the Shifts of Soluble Protein Fractions From Rat Liver and on the Arginase I Activity

Barseghyan

Karapetyan

Trchоunian³

2021

Proc. YSU B: Chem. Biol. Sci.

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Asthenia and fatigue in hyperammonemia: etiopathogenesis and methods of correction

2022

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Asthenia and fatigue are the most common syndromes in patients with liver disease, which significantly affects their quality of life. The prevalence of fatigue in chronic liver diseases is from 50% to 85%. While some progress has been made in understanding the processes that can cause fatigue in general, the underlying causes of fatigue associated with liver disease remain not well understood. In particular, many data suggest that fatigue associated with liver disease likely results from changes in neurotransmission in the brain against the background of hyperammonemia. Hyperammonemia is a metabolic state characterized by an increased level of ammonia, a nitrogen-containing compound. The present review describes hyperammonemia, which is likely important in the pathogenesis of fatigue associated with liver disease. Ammonia is a potent neurotoxin, its elevated blood levels can cause neurological signs and symptoms that can be acute or chronic, depending on the underlying pathology. Hyperammonemia should be recognized early, and immediately treated to prevent the development of life-threatening complications, such as, swelling of the brain and coma. The article gives pathophysiological mechanisms of influence of hyperammonemia on state of psychovegetative status of patients with liver diseases, also lists basic principles of treatment. A significant part of the article is devoted to L-ornithine-L-aspartate, which is effective in asthenia and fatigue to reduce the level of hyperammonemia through a variety of well-studied mechanisms in chronic liver diseases.

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Effect of l-ornithine-l-aspartate therapy on the hyperammonemia level and results of the number connection test of patients suffering from nonalcoholic fatty liver disease

Кизова

Потехина

2020

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The aim was to study the hyperammonemia level and the duration of implementation of the number connection test (NCT) for patients with nonalcoholic fatty liver disease (NAFLD) in the pre-cirrhosis stage, including effect of the oral administration of L-ornithine-L-aspartate (LOLA) on these indices, and NCT correlation with body chemistry values. Material and methods: the research covered 103 patients with NAFLD to study the hyperammonemia level and other relevant blood chemistry values; we performed NCT before and after the LOLA treatment. The aim was to study the hyperammonemia level and the duration of implementation of the number connection test (NCT) for patients with nonalcoholic fatty liver disease (NAFLD) in the pre-cirrhosis stage, including effect of the oral administration of L-ornithine-L-aspartate (LOLA) on these indices, and NCT correlation with body chemistry values. Material and methods: the research covered 103 patients with NAFLD to study the hyperammonemia level and other relevant blood chemistry values; we performed NCT before and after the LOLA treatment.

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Different types of hyperammonemia in clinical practice

Cited by 7 publications

References 60 publications

Effect of Vibration Stress Both on the Shifts of Soluble Protein Fractions From Rat Liver and on the Arginase I Activity

Effect of Vibration Stress Both on the Shifts of Soluble Protein Fractions From Rat Liver and on the Arginase I Activity

Asthenia and fatigue in hyperammonemia: etiopathogenesis and methods of correction

Effect of l-ornithine-l-aspartate therapy on the hyperammonemia level and results of the number connection test of patients suffering from nonalcoholic fatty liver disease

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