Different Treatment Modalities of Advanced Stages of Laryngeal Squamous Cell Carcinoma.

Abstract

this study showed that better locoregional control in cases managed surgically than cases managed by organ preservation protocol (incidence of recurrence was lower in cases managed surgically). Assessment of laryngeal functions showed that swallowing difficulties were less evident in cases managed by total laryngectomy than cases managed by organ preservation . Also there were anatomical abnormalities like anterior pouch, pseudo epiglottis and delayed peristalsis after laryngectomy. while Respiratory function assessment showed non-significant differences between both groups regarding daily activities. Tumor stage, lymph node metastasis, smoking and age of the patients had great effect on the result. Advanced tumor stage (T4), lymph node invasion and smoking were associated with higher incidence of tumor recurrence. Also advanced tumor stage and old age were associated with more swallowing difficulties after management in both groups.