Different techniques for ultrasound liver elastography

Mulazzani, Lorenzo; Cantisani, Vito; Piscaglia, Fabio

doi:10.1016/j.jhep.2018.10.012

Cited by 15 publications

(13 citation statements)

References 10 publications

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“…Liver ultrasound elastography is suitable as non-invasive assessment tool. There are different techniques available within liver ultrasonography, such as vibration-controlled transient elastography (TE), two-dimensional shear-wave elastography (2D-SWE) and point shear-wave elastography (pSWE) (69). These methods are broadly similar, but differ in terms of technical principles and sampling rate (70).…”

Section: Discussionmentioning

confidence: 99%

Metabolic Syndrome Is Associated With Advanced Liver Fibrosis Among Pediatric Patients With Non-alcoholic Fatty Liver Disease

et al. 2019

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Background: Non-alcoholic fatty liver disease (NAFLD) among children is a growing concern with potential significant outcome. This study aims to investigate the relationship between hepatic steatosis, metabolic syndrome, and liver fibrosis among children with obesity and diabetes mellitus.Methodology: Children aged 6–18 years old were recruited from pediatric obesity and diabetes clinic in University Malaya Medical Center (UMMC) between year 2016 and 2019. Data on basic demographics, anthropometric measurements and clinical components of metabolic syndrome were collected. Transient elastography was performed with hepatic steatosis and liver fibrosis assessed by controlled attenuation parameter (CAP) and liver stiffness measurement (LSM) respectively. Mild, moderate and severe steatosis were defined as >248, >268, and >280 dB/m respectively, and LSM above 7.0 kPa for fibrosis stage F ≥ 2, 8.7 kPa for F ≥ 3, and 10.3 kPa for F4 (cirrhosis).Results: A total of 57 children (60% male) with median age of 13 years old were recruited. Fifty (87.7%) of the children are obese and 27 (54%) out of 50 are morbidly obese. Among 44 (77.2%) patients with steatosis, 40 (70.2%) had severe steatosis and 18 (40.9%) had developed liver fibrosis of stage 2 and above. Advanced fibrosis or cirrhosis was detected in 8 (18.2%) children with presence of steatosis. Twenty-three out of 57 (40.4%) was diagnosed with metabolic syndrome. Fibrosis is three times more likely to occur in the presence of metabolic syndrome (OR = 3.545, 95% CI: 1.135–11.075, p = 0.026). Waist circumference is a significant predictor of fibrosis after multiple regression analysis.Conclusion: Obese children with metabolic syndrome are more likely to have advanced liver fibrosis compared to those without metabolic syndrome. Waist circumference predicts development of liver fibrosis.

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Section: Discussionmentioning

confidence: 99%

Metabolic Syndrome Is Associated With Advanced Liver Fibrosis Among Pediatric Patients With Non-alcoholic Fatty Liver Disease

et al. 2019

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“…However, a previous study showed only moderate concordance of different SWE techniques with TE results for the staging of significant fibrosis, suggesting that TE thresholds cannot be directly transferred to other elastography machines [41]. Consequently, specific thresholds for fibrosis staging, ≥F2 in particular, would be required for each specific piece of equipment grounded on scientific research [40]. Nonetheless, the optimal cutoff values proposed for 2D SWE varied across the published studies.…”

Section: Discussionmentioning

confidence: 99%

“…Traditionally, TE is considered as an alternative to biopsy and a reference technique for defining fibrosis staging for other novel SWE technologies, including 2D SWE [40]. However, a previous study showed only moderate concordance of different SWE techniques with TE results for the staging of significant fibrosis, suggesting that TE thresholds cannot be directly transferred to other elastography machines [41].…”

Section: Discussionmentioning

confidence: 99%

Two-dimensional shear wave elastography for significant liver fibrosis in patients with chronic hepatitis B: A systematic review and meta-analysis

Wei

Jiang

et al. 2020

European Journal of Radiology

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To determine the diagnostic performance and cutoff value of two-dimensional shear wave elastography (2D SWE) for detecting significant liver fibrosis in patients with chronic hepatitis B (CHB). Methods: A systematic literature search of the PubMed, EMBASE, Cochrane Library databases and Web of Science was conducted. Bivariate modelling and summary receiver-operating-characteristic (ROC) modelling were constructed to summarize the diagnostic performance of 2D SWE. Meta-regression analyses were performed to explore the source of heterogeneity. Results: Eleven eligible studies with 2623 patients were included. 2D SWE showed a summary sensitivity of 88 % (95 % CI: 83-91), specificity of 83 % (95 % CI: 78-88) and area under the ROC curve of 0.92 (95 % CI: 0.89-0.94) for detecting significant fibrosis in CHB patients. The mean threshold of 2D SWE was 7.91 kPa (range: 6.73-10.00 kPa). Notably, the cutoffs of studies excluding patients with history of prior antiviral therapy were generally lower than that of studies without excluding those who had received antiviral treatment, with an average of 7.15 kPa and 8.87 kPa, respectively (p < 0.01). Meta-regression analysis revealed that enrollment of consecutive patients was the only significant factor influencing heterogeneity (p < 0.01). Specifically, studies recruiting consecutive patients with CHB had significantly lower sensitivity than those with absence of consecutive enrolment (0.83 vs 0.92, p < 0.01). Conclusions: 2D SWE is an excellent modality for predicting significant liver fibrosis in CHB populations. Further work is required to establish the cutoffs that account for antiviral treatment as a potential confounding factor.

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“…Qualitative imaging is performed using mechanical forces or intrinsic internal forces, whereas quantitative imaging is generally performed through the application of force produced by an ultrasound probe [26]. The 3 ultrasound elastography methods in use today are TE; point shear wave elastography (pSWE), also known as acoustic radiation force impulse quantification; and 2-dimensional shear wave elastography (SWE) (Figure 3) [27,28]. SWE uses qualitative and quantitative techniques (Figure 4) [26].…”

Section: Ultrasound Elastographymentioning

confidence: 99%

“…TE, transient elastography; SWE, shear wave elastography; pSWE, point shear wave elastography; ROI, region of interest; ULN, upper limit of normal; HBV/HCV, hepatitis B virus/hepatitis C virus. (Image reproduced from Mulazzani et al[28] with permission from Elsevier. )…”

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confidence: 99%

Imaging in Hepatic Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome

Chan

Colecchia

Duarte

et al. 2020

Biology of Blood and Marrow Transplantation

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Veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is a potentially life-threatening complication of hematopoietic cell transplantation. Early diagnosis and, subsequently, earlier intervention have been shown to be beneficial to clinical outcomes. Diagnostic criteria from the European Society for Blood and Marrow Transplantation include recommendations on the use of imaging for diagnosis. This review discusses evidence on the use of imaging in the management of VOD/SOS and how imaging biomarkers can contribute to earlier diagnosis/treatment.

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Different techniques for ultrasound liver elastography

Cited by 15 publications

References 10 publications

Metabolic Syndrome Is Associated With Advanced Liver Fibrosis Among Pediatric Patients With Non-alcoholic Fatty Liver Disease

Metabolic Syndrome Is Associated With Advanced Liver Fibrosis Among Pediatric Patients With Non-alcoholic Fatty Liver Disease

Two-dimensional shear wave elastography for significant liver fibrosis in patients with chronic hepatitis B: A systematic review and meta-analysis

Imaging in Hepatic Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome

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