Different technical possibilities of post- -therapeutic tandem 90Y/ /177Lu-DOTATATE imaging

Kunikowska, Jolanta; Bajera, Adam; Sawicka, Magdalena; Czwarnowski, P.; Pawłowicz, Bożena; Aksamit, D.; Pawlak, Dariusz; Królicki, Leszek

doi:10.5603/nmr.2013.0038

Cited by 3 publications

(2 citation statements)

References 14 publications

(23 reference statements)

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“…CALDOSE was modi ed to perform Gaussian ltering of the uniform activity distribution before the convolution calculation, simulating image blurring. Spatial resolutions in SPECT images may vary considerably (mainly, between 8-14 mm, as results from phantom studies), depending on general features of the SPECT system, image reconstruction methods, pre-and post-reconstruction ltering and radionuclide (Autret et al 2005, Gear et al 2007, Rault et al 2007, Seo et al 2010, Knoll et al 2012, Seret et al 2012, Kunikowska et al 2013. Three Gaussian PSFs with full-width-at-half-maximum (FWHM) of 6, 8 and 12 mm were chosen to blur absorbed dose distributions.…”

Section: Methodsmentioning

confidence: 99%

Differences in 3D dose distributions due to calculation method of voxel S-values and the influence of image blurring in SPECT

Pacilio¹,

Amato²,

Lanconelli³

et al. 2015

Phys. Med. Biol.

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This study compares 3D dose distributions obtained with voxel S values (VSVs) for soft tissue, calculated by several methods at their current state-of-the-art, varying the degree of image blurring. The methods were: 1) convolution of Dose Point Kernel (DPK) for water, using a scaling factor method; 2) an analytical model (AM), tting the deposited energy as a function of the source-target distance; 3) a rescaling method (RSM) based on a set of high-resolution VSVs for each isotope; 4) local energy deposition (LED). VSVs calculated by direct Monte Carlo simulations were assumed as reference. Dose distributions were calculated considering spheroidal clusters with various sizes (251, 1237 and 4139 voxels of 3 mm size), uniformly lled with 131 I, 177 Lu, 188 Re or 90 Y. The activity distributions were blurred with Gaussian lters of various widths (6, 8 and 12 mm). Moreover, 3D-dosimetry was performed for 10 treatments with 90 Y derivatives. Cumulative Dose Volume Histograms (cDVHs) were compared, studying the differences in D 95% , D 50% or D max (∆D 95% , ∆D 50% and ∆D max) and dose pro les.

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Section: Methodsmentioning

confidence: 99%

Differences in 3D dose distributions due to calculation method of voxel S-values and the influence of image blurring in SPECT

Pacilio¹,

Amato²,

Lanconelli³

et al. 2015

Phys. Med. Biol.

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“…Dual-isotope SPECT imaging based on Monte Carlo simulations have been performed for radioisotope pairs such as 99m Tc/ 123 I [35] 123 I/ 125 I [36], and combinations of 99m Tc, 111 In, 123 I, 177 Lu, and 201 Tl [37], but not 177 Lu and 90 Y. Dosimetry simulations of 177 Lu and 90 Y therapy have been performed [38,39] which highlights the importance of a study such as ours; dosimetry is impractical outside of a simulation if imaging cannot be performed quantitatively. Imaging has been performed in dual-isotope PRRT with 177 Lu and 90 Y [40], but dosimetry was not performed. We also simulated a wide range of 177 Lu and 90 Y source and background activity concentrations, which allowed us to generate data that is more representative of a true patient population.…”

Section: Discussionmentioning

confidence: 99%

¹⁷⁷Lu SPECT imaging in the presence of ⁹⁰Y: does ⁹⁰Y degrade image quantification? a simulation study

Miller

Uribe

Hou

et al. 2023

Biomed. Phys. Eng. Express

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This work aims to investigate the accuracy of quantitative SPECT imaging of 177Lu in the presence of 90Y, which occurs in dual-isotope radiopharmaceutical therapy (RPT) involving both isotopes. We used the GATE Monte Carlo simulation toolkit to conduct a phantom study, simulating spheres filled with 177Lu and 90Y placed in a cylindrical water phantom that was also filled with activity of both radionuclides. We simulated multiple phantom configurations and activity combinations by varying the location of the spheres, the concentrations of 177Lu and 90Y in the spheres, and the amount of background activity. We investigated two different scatter window widths to be used with triple energy window (TEW) scatter correction. We also created multiple realizations of each configuration to improve our assessment, leading to a total of 540 simulations. Each configuration was imaged using a simulated Siemens SPECT camera. The projections were reconstructed using the standard 3D OSEM algorithm, and errors associated with 177Lu activity quantification and contrast-to-noise ratios (CNRs) were determined. In all configurations, the quantification error was within ± 6% of the no-90Y case, and we found that quantitative accuracy may slightly improve when 90Y is present because of reduction of errors associated with TEW scatter correction. The CNRs were not significantly impacted by the presence of 90Y, but they were increased when a wider scatter window width was used for TEW scatter correction. The width of the scatter windows made a small but statistically significant difference of 1-2% on the recovered 177Lu activity. Based on these results, we can conclude that activity quantification of 177Lu and lesion detectability is not degraded by the presence of 90Y.

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Sequential Duo–Peptide Receptor Radionuclide Therapy With Indigenous 90Y-DOTATATE and 177Lu-DOTATATE in Large-Volume Neuroendocrine Tumors

et al. 2020

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The efficacy of 177Lu-DOTATATE in large neuroendocrine tumors (NETs) is reduced because of the lower energy (Eβmax 0.497 MeV) and shorter range of 177Lu. The pure β-emitter 90Y with its longer β range is more effective in larger tumors. This should be balanced with the greater risk of 90Y-DOTATATE–related nephrotoxicity. Sequential duo–peptide receptor radionuclide therapy may result in a better response with minimal adverse effects in large-volume heterogeneous NETs. A 56-year-old man with large rectal NET liver metastases, treated with 90Y-DOTATATE and 177Lu-DOTATATE and sequential duo–peptide receptor radionuclide therapy, presented with post-90Y-DOTATATE bremsstrahlung and PET/CT in comparison with 68Ga-DOTATATE PET/CT and 177Lu-DOTATATE scans.

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Different technical possibilities of post- -therapeutic tandem 90Y/ /177Lu-DOTATATE imaging

Cited by 3 publications

References 14 publications

Differences in 3D dose distributions due to calculation method of voxel S-values and the influence of image blurring in SPECT

Differences in 3D dose distributions due to calculation method of voxel S-values and the influence of image blurring in SPECT

¹⁷⁷Lu SPECT imaging in the presence of ⁹⁰Y: does ⁹⁰Y degrade image quantification? a simulation study

Sequential Duo–Peptide Receptor Radionuclide Therapy With Indigenous 90Y-DOTATATE and 177Lu-DOTATATE in Large-Volume Neuroendocrine Tumors

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Different technical possibilities of post- -therapeutic tandem 90Y/ /177Lu-DOTATATE imaging

Cited by 3 publications

References 14 publications

Differences in 3D dose distributions due to calculation method of voxel S-values and the influence of image blurring in SPECT

Differences in 3D dose distributions due to calculation method of voxel S-values and the influence of image blurring in SPECT

177Lu SPECT imaging in the presence of 90Y: does 90Y degrade image quantification? a simulation study

Sequential Duo–Peptide Receptor Radionuclide Therapy With Indigenous 90Y-DOTATATE and 177Lu-DOTATATE in Large-Volume Neuroendocrine Tumors

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¹⁷⁷Lu SPECT imaging in the presence of ⁹⁰Y: does ⁹⁰Y degrade image quantification? a simulation study