Different Targeting Ligands-Mediated Drug Delivery Systems for Tumor Therapy

Yan, Shuxin; Na, Jintong; Liu, Xiyu; Wu, Pan

doi:10.3390/pharmaceutics16020248

Cited by 7 publications

(3 citation statements)

References 110 publications

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“…These hybrids combine the intrinsic biological functions of living cells with the functionality of the polymers/nanomaterials. Interestingly, after modification with nanomaterials or with polymers, the cells can remain active or remain in hibernation without being killed [ 162 ]. These “cyborg cells” have attractive applications in the biomedical field (biosensing, cell-therapy, delivery, tissue regeneration, etc.).…”

Section: The Main Categories Of Commonly Used Nanopharmaceuticalsmentioning

confidence: 99%

“…For example, exoskeleton structures of MOF nanoparticles were developed by metal–phenolic coordination for RBCs encapsulation. In these cyborg hybrids, RBCs’ membranes and MOF NPs were complexed through hydrogen bonding, without the lysis of RBCs [ 162 ]. Such hybrids possess resistance against harsh factors and can be used for multimodal imaging and for sensing the blood’s nitric oxide.…”

Section: The Main Categories Of Commonly Used Nanopharmaceuticalsmentioning

confidence: 99%

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Nanoformulations in Pharmaceutical and Biomedical Applications: Green Perspectives

Petrovic,

Bita,

Barbinta-Patrascu

2024

IJMS

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This study provides a brief discussion of the major nanopharmaceuticals formulations as well as the impact of nanotechnology on the future of pharmaceuticals. Effective and eco-friendly strategies of biofabrication are also highlighted. Modern approaches to designing pharmaceutical nanoformulations (e.g., 3D printing, Phyto-Nanotechnology, Biomimetics/Bioinspiration, etc.) are outlined. This paper discusses the need to use natural resources for the “green” design of new nanoformulations with therapeutic efficiency. Nanopharmaceuticals research is still in its early stages, and the preparation of nanomaterials must be carefully considered. Therefore, safety and long-term effects of pharmaceutical nanoformulations must not be overlooked. The testing of nanopharmaceuticals represents an essential point in their further applications. Vegetal scaffolds obtained by decellularizing plant leaves represent a valuable, bioinspired model for nanopharmaceutical testing that avoids using animals. Nanoformulations are critical in various fields, especially in pharmacy, medicine, agriculture, and material science, due to their unique properties and advantages over conventional formulations that allows improved solubility, bioavailability, targeted drug delivery, controlled release, and reduced toxicity. Nanopharmaceuticals have transitioned from experimental stages to being a vital component of clinical practice, significantly improving outcomes in medical fields for cancer treatment, infectious diseases, neurological disorders, personalized medicine, and advanced diagnostics. Here are the key points highlighting their importance. The significant challenges, opportunities, and future directions are mentioned in the final section.

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Section: The Main Categories Of Commonly Used Nanopharmaceuticalsmentioning

confidence: 99%

Section: The Main Categories Of Commonly Used Nanopharmaceuticalsmentioning

confidence: 99%

Nanoformulations in Pharmaceutical and Biomedical Applications: Green Perspectives

Petrovic,

Bita,

Barbinta-Patrascu

2024

IJMS

View full text Add to dashboard Cite

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“…Ligands/antibodies play a crucial role in distinguishing pathological from normal tissues by specifically binding to receptors/antigens overexpressed on the surface of cancer cells, minimizing damage to normal cells and exhibiting high cell selectivity. 87 Common biological ligands include protein or peptide antibodies, hyaluronic acid, folate, etc. This article focuses on constructing TDDS for TS/TV and its active components in cancer treatment, based on Integrin α v β 3 , Asialoglycoprotein, Low Density Lipoprotein, Bile Acid, Folate, Transferrin, Epidermal Growth Factor, Biotin receptors and CD40 receptors.…”

Section: Active Targeted Drug Delivery Systemmentioning

confidence: 99%

Advances on Delivery System of Active Ingredients of Dried Toad Skin and Toad Venom

Zhang,

Zhai,

Sun

et al. 2024

IJN

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Dried toad skin (TS) and toad venom (TV) are the dried skin of the Bufo bufo gargarizans Cantor and the Bufo melanostictus Schneider , which remove the internal organs and the white secretions of the skin and retroauricular glands. Since 2005, cinobufacini preparations have been approved by the State Food and Drug Administration for use as adjuvant therapies in the treatment of various advanced cancers. Meanwhile, bufalenolides has been identified as the main component of TS/TV, exhibiting antitumor activity, inducing apoptosis of cancer cells and inhibiting cancer cell proliferation or metastasis through a variety of signaling pathways. However, clinical agents frequently face limitations such as inherent toxicity at high concentrations and insufficient tumor targeting. Additionally, the development and utilization of these active ingredients are hindered by poor water solubility, low bioavailability, and rapid clearance from the bloodstream. To address these challenges, the design of a targeted drug delivery system (TDDS) aims to enhance drug bioavailability, improve targeting within the body, increase drug efficacy, and reduce adverse reactions. This article reviews the TDDS for TS/TV, and their active components, including passive, active, and stimuli-responsive TDDS, to provide a reference for advancing their clinical development and use.

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Light‐Driven Multi‐Core/Shell Microdroplets as a Targeted Drug Delivery System

Yuan,

Yao,

Yang

et al. 2024

Adv Funct Materials

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Targeted drug delivery system (DDS) holds exciting prospects in biomedical clinical research and drug development. However, it faces a significant challenge in achieving stable and safe targeted transportation without drug leakage while obtaining precise and controllable drug dosing with a high drug utilization rate and low side effects. Herein, an optical tweezers‐based light‐driven technique is proposed to transport and construct multi‐core/shell microdroplets enveloping drug carriers and target cells as a novel, safe, and efficient targeted DDS. Drug‐loaded microdroplets with core/shell structures are first fabricated by a new and simple injection extrusion method and then it is transported to a target cell by a dynamic optical trap with a low optical power, which ensures no drug leakage, exogenous materials, and biothermal damage are introduced during the drug delivery process. Next, precise drug dosing is realized by pushing the target cell into the drug‐loaded microdroplet under the actions of optical forces, which constructs a multi‐core/shell microdroplet structure with a pure drug environment to improve the drug action efficiency. Moreover, quantitative drug dosing with a high drug utilization rate can also achieved by controlling the sizes/number of drug droplets inside the microdroplets. This light‐driven DDS is of great interest to frontier medical research and disease treatment fields.

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Different Targeting Ligands-Mediated Drug Delivery Systems for Tumor Therapy

Cited by 7 publications

References 110 publications

Nanoformulations in Pharmaceutical and Biomedical Applications: Green Perspectives

Nanoformulations in Pharmaceutical and Biomedical Applications: Green Perspectives

Advances on Delivery System of Active Ingredients of Dried Toad Skin and Toad Venom

Light‐Driven Multi‐Core/Shell Microdroplets as a Targeted Drug Delivery System

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