Different sympathetic–parasympathetic interactions on sinus rate and AV conduction in dog hearts

Furukawa, Yoshiko; Takei, Manabu; Narita, Michiko; Karasawa, Yasuyuki; Tada, Akihiro; Zenda, Hiroshi; Chiba, Shigetoshi

doi:10.1016/s0014-2999(97)01177-1

Cited by 5 publications

(4 citation statements)

References 32 publications

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“…However, the relative roles of sympathetic and vagal influences are likely different between them, given that the cellular mechanisms of autonomic regulation of sinoatrial automaticity are distinct from those affecting conduction velocity and refractoriness of nodal tissue. Indeed, these differential effects have been well demonstrated in animal models 22–25 . To the extent that both short‐term HRV parameters and entropy are determined by autonomics, these differences in sympathovagal balance between the SA node and the AV node act to weaken the correlations we studied here.…”

Section: Discussionmentioning

confidence: 77%

Heart Rate Variability Measures During Sinus Rhythm Predict Cycle Length Entropy During Atrial Fibrillation

Segerson

Smith

Wasmund

et al. 2008

Cardiovasc electrophysiol

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Section: Discussionmentioning

confidence: 77%

Heart Rate Variability Measures During Sinus Rhythm Predict Cycle Length Entropy During Atrial Fibrillation

Segerson

Smith

Wasmund

et al. 2008

Cardiovasc electrophysiol

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“…The relationship between HR and PQ probably originates mainly from the dependence of both parameters on the autonomic system. The sympathetic system increases the HR and velocity of atrioventricular conduction, and therefore shortens PQ interval, whereas the parasympathetic system has the opposite effects (O'Toole et al 1984, Nayebpour et al 1992, Furukawa et al 1997. However, an increase in HR results in a prolongation of atrioventricular conduction time due to an increase in the atrioventricular nodal refractoriness (Warner & Loeb 1986).…”

Section: Discussionmentioning

confidence: 99%

The electrocardiogram of the Beagle dog: reference values and effect of sex, genetic strain, body position and heart rate

Hanton

Rabémampianina

2006

Lab Anim

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SummaryThe aim of the study was to establish a database for electrocardiographic parameters of Beagle dogs used for toxicological studies and to evaluate the influence of supplier, sex, heart rate (HR) and body position for electrocardiogram (ECG) recording on ECG parameters. Peripheral ECG leads were recorded from 934 female and 946 male dogs from Marshall Farms and 27 females and 30 males from Harlan, either standing on a table or restrained in a hammock. HR, RR, PQ and QT intervals, P and QRS duration and P-wave amplitude were measured. There were no major differences between sexes for ECG parameters. The axis of the heart was shifted to the left when the animals were restrained in a hammock compared to when they were standing on a table. The PQ interval was higher (about 9%) in Harlan than in Marshall dogs. HR was negatively correlated with QT (coefficient of linear correlation: r ¼ À0.61 to À0.74), which emphasizes the need for a formula correcting QT interval for HR when interpreting changes in QT interval. HR was also negatively correlated with PQ intervals (r ¼ À0.26 to À0.11), whereas a positive correlation was found between HR and the amplitude of the P wave (r ¼ 0.21-0.34). The level of the respiratory sinus arrhythmia (SA) was quantified by calculating the ratio of maximum to minimum RR interval measured over a 10 s period. This ratio was negatively correlated with HR (r ¼ À0.49 to À0.33). Therefore, at high HRs, SA was less marked than at low HRs, but it did not completely disappear. Analysis of beat-to-beat variation indicated that QT and PQ intervals and the amplitude of P wave fluctuated over time and the degree of this variability was positively correlated with the level of SA. In conclusion, we have established reference values for the duration and/or amplitude of some ECG parameters both in terms of means and variability over the recording period, and we have evaluated the influence of body position, genetic strain and HR on the ECG parameters. These data can be used as baseline for the interpretation of the ECG of Beagle dogs.Keywords Dog; electrocardiogram (ECG); heart rate; QT interval; sinus arrhythmia Electrocardiogram (ECG) is a key examination when evaluating the effects of drugs on the cardiovascular system, and is performed routinely in toxicity and pharmacology studies. It provides critical information on a number of changes in the electrophysiological function, in particular the effects of a test compound on cardiac rhythmicity, conduction, depolarization and repolarization, which cannot be assessed by other methods and which have no morphological correlates visible at

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“…Intrinsic cardiac nervous system (ICNS) plays a crucial role in regulation of heart rate, contractility and tone of the coronary vessels (Young et al 1987;Ardel 1994;Baumgart and Heusch 1995;Furukawa et al 1997;Dickerson et al 1998;Feigl 1998;Tsuboi et al 2000;Randall et al 2003;Olufsen et al 2005). In neonates and infants, the intrinsic neural pathways are considered to be important for radiofrequency ablation that is performable in cases of incessant supraventricular and atrioventricular nodal re-entry tachycardia (Osborn et al 1999;Blaufox et al 2001;Shah et al 2001;Oudijk et al 2003;Van Hare et al 2004).…”

Section: Introductionmentioning

confidence: 99%

Location and variability of epicardiac ganglia in human fetuses

Saburkina

Pauža

2006

Anat Embryol

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The aim of the study was to determine the morphology of epicardiac ganglia in human fetuses at different stages of their development as these ganglia are considered to be of a pivotal clinical importance. Twenty-one fetal hearts were investigated applying a technique of histochemistry for acetylcholinesterase to visualize the epicardiac neural ganglionated plexus with its subsequent stereoscopic examination on total organs. In all of the examined fetuses, epicardiac neural plexus with numerous ganglia was well recognizable and could be clearly differentiated into seven ganglionated subplexuses, topography and structural organization of which were typical for hearts of adult human. The largest ganglion number comprising 77% of all counted ganglia was identified on the dorsal atrial surface. Fetal epicardiac plexus in gestation period of 15-40 weeks contained 929 +/- 62 ganglia, but ganglion amount did vary substantially from heart to heart. In conclusion, this study implies that the human fetal epicardiac ganglia occupy their definitive location already at gestation period from 15 weeks and their number as well as distribution on heart surface presumably is not age dependent.

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Different sympathetic–parasympathetic interactions on sinus rate and AV conduction in dog hearts

Cited by 5 publications

References 32 publications

Heart Rate Variability Measures During Sinus Rhythm Predict Cycle Length Entropy During Atrial Fibrillation

Heart Rate Variability Measures During Sinus Rhythm Predict Cycle Length Entropy During Atrial Fibrillation

The electrocardiogram of the Beagle dog: reference values and effect of sex, genetic strain, body position and heart rate

Location and variability of epicardiac ganglia in human fetuses

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