Different structural remodelling in atrial fibrillation with different types of mitral valvular diseases

Circulating carboxy-terminal propeptide of type I procollagen is increased in rheumatic heart disease

“…Because of extensive stenosis and fibrosis, the mitral valve area is reduced in subjects with predominantly stenotic lesions. Therefore, MVA is considered a severity marker in such subjects [12]. We show that PICP concentration is directly proportional to the degree of stenosis further suggesting that valve related fibrosis might determine plasma PICP levels in rheumatic heart disease subjects.…”

Mitral Regurgitation and Atrial Fibrillation: The Contribution of Impaired Left Atrial Appendage Function to Atrial Thrombogenesis

“…Masson's trichrome staining and immunohistochemical staining were performed to assess the extent of the fibrosis. The authors reported significantly increased fibrosis in patients with AF when compared to patients in sinus rhythm (p=0.023) [28]. The collagen volume fraction of fibrosis was also significantly increased in patients with mitral stenosis and atrial fibrillation when compared to patients with mitral regurgitation and atrial fibrillation (p=0.043) [28].…”

“…The authors reported significantly increased fibrosis in patients with AF when compared to patients in sinus rhythm (p=0.023) [28]. The collagen volume fraction of fibrosis was also significantly increased in patients with mitral stenosis and atrial fibrillation when compared to patients with mitral regurgitation and atrial fibrillation (p=0.043) [28]. Collagen Type I levels were also significantly increased in AF patients with mitral stenosis when compared to patients with mitral regurgitation and AF (p=0.043).…”

“…A recent study aimed to assess the relationship between atrial structural remodelling in AF patients with different types of mitral valve diseases [28]. The study recruited 24 patients undergoing mitral valve surgery with different diagnoses.…”

“…Of note, different collagen volume fraction of Matrix MetalloProteinases-2 (MMP2) was determined between the patients with mitral stenosis and sinus rhythm and patients with mitral stenosis and AF (p=0.001). The authors concluded that heart rhythm status and type of underlying mitral valve disease influence www.intechopen.com atrial structural remodelling and different atrial structural remodelling may contribute to the development of AF [28]. The remodelling processes involving atrial fibrosis and atrial dilatation in AF patients also recruit angiotensin II mediated pathways and MMPs.…”