Different stages of intraplaque hemorrhage are associated with different plaque phenotypes: A large histopathological study in 794 carotid and 276 femoral endarterectomy specimens

Derksen, Wouter J.M.; Peeters, Wouter; Lammeren, Guus W. van; Tersteeg, Claudia; Vries, Jean‐Paul P.M. de; Kleijn, Dominique P.V. de; Moll, Frans L.; Wal, Allard C. van der; Pasterkamp, Gérard; Vink, Aryan

doi:10.1016/j.atherosclerosis.2011.07.104

Cited by 45 publications

(35 citation statements)

References 31 publications

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“…Unstable atherosclerotic plaque is also described to be rich in lipids and poor in VSMCs. 26 In addition to regulation of VSMC proliferation and differentiation, miR-133a and miR-145 may be expressed in other cell types, and may have another role in the plaque destabilization process.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA deregulation in symptomatic carotid plaque

Maitrias

Meuth

Massy

et al. 2015

Journal of Vascular Surgery

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This pilot study evaluated the expression of seven selected miRNAs in human carotid plaques from a small group of patients and suggested a potential regulatory role for these miRNAs in evolution of the plaque towards growth, instability and rupture. Studies based on larger sample sizes are required to determine the potential use of miR-100, miR-125a, miR-127, miR-133a, miR-145, and miR-221 as biomarkers or therapeutic targets for stroke.

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Section: Discussionmentioning

confidence: 99%

MicroRNA deregulation in symptomatic carotid plaque

Maitrias

Meuth

Massy

et al. 2015

Journal of Vascular Surgery

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“…This is much lower compared to other vascular beds such as the carotid (81%), femoral (63%) and the coronary (61%) arteries [24,25]. The prevalence of intraplaque haemorrhage, in particular in the MCA, is more common among symptomatic than asymptomatic patients [26].…”

Section: Topographic Distribution and Morphology Of Intracranial Athementioning

confidence: 93%

Atherosclerosis in the circle of Willis: Spatial differences in composition and in distribution of plaques

et al. 2016

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“…Microvessels were counted in three hot-spots and were expressed as average microvessel density per hotspot [18]. The presence of intraplaque hemorrhage was assessed with Hematoxylin and Eosin (H&E) staining and fibrin (Mallory's phosphotungstic acid-hematoxylin) [19]. Calcification (H&E) and collagen content (Picrosirius red) were scored semi-quantitatively.…”

Section: Immunohistochemistrymentioning

confidence: 99%