1989
DOI: 10.1002/ajh.2830310102
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Different sensitivities of rat and human red cells to exogenous Ca2+

Abstract: During an examination of the effects of shear and of the Ca2+ ionophore A23187 on Ca2+ entry into erythrocytes of rats and humans, we noted that rat erythrocytes were much more sensitive to Ca2+-induced hemolysis than the human cells. An examination of the effect of Ca2+ on transglutaminase, a cytosolic enzyme in the erythrocyte which cross-links membrane proteins and renders cells less deformable, demonstrated a correlation between enzyme activity and Ca2+-induced hemolysis. Both rat and human cells subjected… Show more

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Cited by 9 publications
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“…RBC intracellular ionized calcium concentration in rats ranges from 83 to 105 nmol/l [30] while in humans the physiological range is 20-60 nmol/l [31]. Rat RBCs have also been described as more sensitive to exogenous Ca 2+ than human RBCs [32]. Considering that PS externalization and microvesicle formation are directly correlated with calcium influx [33,34,35], we would expect to see a higher number of MPs in rat samples.…”
Section: Discussionmentioning
confidence: 99%
“…RBC intracellular ionized calcium concentration in rats ranges from 83 to 105 nmol/l [30] while in humans the physiological range is 20-60 nmol/l [31]. Rat RBCs have also been described as more sensitive to exogenous Ca 2+ than human RBCs [32]. Considering that PS externalization and microvesicle formation are directly correlated with calcium influx [33,34,35], we would expect to see a higher number of MPs in rat samples.…”
Section: Discussionmentioning
confidence: 99%