Different roles of lateral anterior temporal lobe and inferior parietal lobule in coding function and manipulation tool knowledge: Evidence from an rTMS study

Ishibashi, Ryo; Ralph, Matthew A. Lambon; Saito, Satoru; Pobric, Gorana

doi:10.1016/j.neuropsychologia.2011.01.004

Cited by 89 publications

(100 citation statements)

References 60 publications

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“…Finally, these findings converge with two recent studies that used transcranial magnetic stimulation to show that, for both photographs of objects (Pobric et al, 2010) and object-words (Ishibashi et al, 2011), a region of the left IPL participates in the representation of the manipulability of the object-that is, how it is used-while a region of the left aTC contains more abstract, modality-nonspecific information about object function-that is, why it is used (see also Canessa et al, 2008). These regions correspond well with the left IPL and left aTC regions observed to be associated with representing action implementation ("how") and motive ("why"), respectively, in the present study.…”

Section: Discussionsupporting

confidence: 89%

Dissociating Modality-Specific and Supramodal Neural Systems for Action Understanding

Spunt

Lieberman²

2012

J. Neurosci.

142

127

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The neural basis of action understanding in humans remains disputed, with some research implicating the putative mirror neuron system (MNS) and some a mentalizing system (MZS) for inferring mental states. The basis for this dispute may be that action understanding is a heterogeneous construct: actions can be understood from sensory information about body movements or from language about action, and with the goal of understanding the implementation ("how") or motive ("why") of an action. Although extant research implicates the MNS in understanding implementation and the MZS in understanding motive, it remains unknown to what extent these systems subserve modality-specific or supramodal functions in action understanding. While undergoing fMRI, 21 volunteers considered the implementation ("How is she doing it?") and motive ("Why is she doing it?") for actions presented in video or text. Bilateral parietal and right frontal areas of the MNS showed a modality-specific association with perceiving actions in videos, while left-hemisphere MNS showed a supramodal association with understanding implementation. Largely left-hemisphere MZS showed a supramodal association with understanding motive; however, connectivity among the MZS and MNS during the inference of motive was modality specific, being significantly stronger when motive was understood from actions in videos compared to text. These results support a tripartite model of MNS and MZS contributions to action understanding, where distinct areas of the MNS contribute to action perception ("perceiving what") and the representation of action implementation ("knowing how"), while the MZS supports an abstract, modality-independent representation of the mental states that explain action performance ("knowing why").

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Section: Discussionsupporting

confidence: 89%

Dissociating Modality-Specific and Supramodal Neural Systems for Action Understanding

Spunt

Lieberman²

2012

J. Neurosci.

142

127

View full text Add to dashboard Cite

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“…Therefore, errors in the perception of object manipulation can occur after damage external to left IPL, suggesting that the ventro-dorsal stream can be indirectly disturbed by disrupting communication at different parts of the pathway. These findings support previous research confirming that lesions implicating the left IPL can give rise to apraxia and result in impaired perception of object-use manipulation Daprati & Sirigu, 2006;Buxbaum et al, 2007;Goldenberg 2009;Ishibashi et al, 2011). They also suggest that apraxia may be associated with deficits in motor imagery, which in turn compromise the integration of known and visual object properties.…”

Section: * Discussionsupporting

confidence: 90%

“…Using repetitive transcranial magnetic stimulation (rTMS), stimulation of the left IPL slows object manipulation judgements whereas anterior temporal lobe stimulation slows function judgements (Ishibashi, Lambon Ralph, Saito, & Pobric, 2011). The perception of object function appears to be attributed to more ventral and semantic systems (Hodges, Bozeat, Lambon Ralph, Patterson, & Spatt, 2000).…”

Section: Introductionmentioning

confidence: 99%

Perceptual decisions regarding object manipulation are selectively impaired in apraxia or when tDCS is applied over the left IPL

et al. 2016

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This study evaluated whether apraxia can be understood as due to impaired motor representations or motor imagery necessary for appropriate object-use, imitation, and pantomime. The causal role of the left inferior parietal lobe (IPL), which is heavily implicated in apraxia, is also evaluated. These processes are appraised in light of the proposed ventro-dorsal sub-stream of the classic two visual pathway model, where perceptual information from the ventral stream and the dorsal action stream are integrated and essential for object manipulation. Using a task assessing object-use perception, stroke patients with apraxia demonstrated a selective deficit during perceptual decisions reliant on the integration of visible and known object properties to select the appropriate grasp for object-use. This deficit increased with apraxia severity. A dissociation was evident in these patients showing intact non-motoric perceptual decisions regarding the functional semantic relationship between two objects in the absence of the actor (e.g. how a hammer hits a nail). Converging evidence was found using a modified version of the same task in a neuromodulation study that directly targeted the left IPL in healthy participants using transcranial direct current stimulation (tDCS). Application of inhibitory stimulation over the left IPL reduced performance during perceptual decisions regarding object manipulation whilst performance was unaffected during functional semantic decisions. Excitatory stimulation of the left IPL did not affect performance in either task. Combined, these results suggest that the left inferior parietal lobe is critical for motor imagery, and that apraxia may be caused by an inability to use internal motor representations of object manipulation. These results are discussed in terms of motoric and non-motoric perceptual processes and the proposal of an additional ventro-dorsal sub-stream within the dorsal and ventral visual pathways model

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“…The results showed that HF rTMS to the right DLPFC increased RT selectively during the decision phase, demonstrating the roles of the PPC and the DLPFC in the delay and decision phases related to spatial working memory. In a study on the lateral anterior temporal lobe (ATL) and the inferior parietal lobule (IPL) in coding function (what for) and manipulation (how) of tools [33], LF rTMS to lateral ATL increased RT for the "function" judgments, whereas LF rTMS of IPL increased RT for the "manipulation" judgments. Gongora et al [25] conducted a visuomotor task using LF rTMS and quantitative electroencephalography.…”

Section: Decision-makingmentioning

confidence: 99%

“…In decision-making studies relevant to cognitive functions, rTMS affects visuospatial attention [71], perception [57], object identification [77], spatial working memory [36], function and manipulation tool knowledge [33], and visuomotor tasks [25].…”

Section: Decision-makingmentioning

confidence: 99%

The modulating effects of brain stimulation on emotion regulation and decision-making

Choi

Scott

Lim

2016

Neuropsychiatr Electrophysiol

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Background: It has been reported that brain stimulation such as repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) can modulate a variety of cognitions and emotions in humans. rTMS and tDCS studies provide strong possibilities of applications in the manipulation of emotion regulation and decision-making in humans. Methods: We searched the literature by using keywords "rTMS," "tDCS," "emotion regulation," and "decision-making" on PubMed (http://www.ncbi.nlm.nih.gov/pubmed). Based on the search results, we reviewed studies on emotion regulation and decision-making using rTMS and tDCS modulations.

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Different roles of lateral anterior temporal lobe and inferior parietal lobule in coding function and manipulation tool knowledge: Evidence from an rTMS study

Cited by 89 publications

References 60 publications

Dissociating Modality-Specific and Supramodal Neural Systems for Action Understanding

Dissociating Modality-Specific and Supramodal Neural Systems for Action Understanding

Perceptual decisions regarding object manipulation are selectively impaired in apraxia or when tDCS is applied over the left IPL

The modulating effects of brain stimulation on emotion regulation and decision-making

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