Different roles of D-1 and D-2 dopamine receptors involved in locomotor activity of supersensitive mice

Rubinstein, Marcelo; Gershanik, Oscar S.; Stefano, F. J. E.

doi:10.1016/0014-2999(88)90121-5

Cited by 45 publications

(18 citation statements)

References 19 publications

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“…3). As previously reported (Rubinstein et al, 1988;Starr et al. 1987;Ferré et al, 1991Ferré et al, ,1994, co-administration of SKF 38393 and quinpirole in reserpinized mice produced a synergistic motor activating effect.…”

Section: H 3 -D 1 and H 3 -D 2 Receptor Interactions In Reserpinized supporting

confidence: 56%

“…The evaluation of locomotor activity induced by dopamine receptor agonists in reserpinized mice is a very useful in vivo model to study the function of striatal postsynaptic D 1 and D 2 receptors, which are predominantly localized in GABAergic dynorphinergic and GABAergic enkephalinergic neurons, respectively, without the influence of endogenous dopamine (Rubinstein et al, 1988;Starr et al, 1987;Ferré et al, 1991Ferré et al, , 1994b. By using the reserpinized mouse model, in the present study, we demonstrate the existence of H 3 receptor-mediated negative modulation of D 1 and D 2 receptor function.…”

Section: Discussionmentioning

confidence: 99%

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Interactions between histamine H3 and dopamine D2 receptors and the implications for striatal function

et al. 2008

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The striatum contains a high density of histamine H 3 receptors, but their role in striatal function is poorly understood. Previous studies have demonstrated antagonistic interactions between striatal H 3 and dopamine D 1 receptors at the biochemical level, while contradictory results have been reported about interactions between striatal H 3 and dopamine D 2 receptors. In the present study, by using reserpinized mice, we demonstrate the existence of behaviorally significant antagonistic postsynaptic interactions between H 3 and D 1 and also between H 3 and dopamine D 2 receptors. The selective H 3 receptor agonist imetit inhibited, while the H 3 receptor antagonist thioperamide potentiated locomotor activation induced by either the D 1 receptor agonist SKF 38393 or the D 2 receptor agonist quinpirole. High scores of locomotor activity were obtained with H 3 receptor blockade plus D 1 and D 2 receptor co-activation, i.e., when thioperamide was co-administered with both SKF 38393 and quinpirole. Radioligand binding experiments in striatal membrane preparations showed the existence of a strong and selective H 3 -D 2 receptor interaction at the membrane level. In agonist/antagonist competition experiments stimulation of H 3 receptors with several H 3 receptor agonists significantly decreased the affinity of D 2 receptors for the agonist. This kind of intramembrane receptor-receptor interactions are a common biochemical property of receptor heteromers. In fact, by using Bioluminescence Resonance Energy Transfer techniques in cotransfected HEK-293 cells, H 3 (but not H 4 ) receptors were found to form heteromers with D 2 receptors. The present study demonstrates an important role of postsynaptic H 3 receptors in the modulation of dopaminergic transmission by means of a negative modulation of D 2 receptor function.

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Section: H 3 -D 1 and H 3 -D 2 Receptor Interactions In Reserpinized supporting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Interactions between histamine H3 and dopamine D2 receptors and the implications for striatal function

et al. 2008

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“…In both cases there is a widespread depletion of dopamine and other monoamines across the brain (Start et al, 1987), resulting in an upregulation of dopamine receptors and/or their associated second messenger systems (Rubinstein et al, 1990) and a heightened sensitivity to dopamine agonists (Rubinstein et al, 1988). We therefore consider that our present results may have a direct bearing on the way that glutamate antagonists could be expected to interact with dopamine agonists in the treatment of human PD.…”

Section: Discussionmentioning

confidence: 78%

Glutamate antagonists modify the motor stimulant actions of D1 and D2 agonists in reserpine-treated mice in complex ways that are not predictive of their interactions with the mixed D1/D2 agonist apomorphine

1993

J Neural Transm Gen Sect

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In 24h reserpine-treated mice, the locomotion induced by the D1 dopamine agonist SKF 38393 (30 mg/kg IP) was facilitated by the NMDA antagonists MK 801 (0.4 mg/kg IP), CPP (1 mg/kg IP), CGP 40116 (1 mg/kg IP) and HA 966 (2 mg/kg IP), and by the AMPA antagonist NBQX (0.2 mg/kg IP). By contrast, CPP, CGP 40116 and NBQX had no effect on, while MK 801 and HA 966 suppressed, the locomotion elicited by the selective D2 agonist RU 24213 (5 mg/kg SC). When these same doses of glutamate antagonists were tested against the locomotion induced by a threshold (0.025 mg/kg SC), intermediate (0.1 mg/kg SC) or large dose (0.5 mg/kg SC) of the mixed D1/D2 agonist apomorphine, CPP, CGP 40116 and HA 966 were found to have no significant effect, whilst MK 801 was strongly inhibitory and NBQX potentiated the response to 0.1 mg/kg apomorphine only. It is evident from these data that the behavioural interaction profiles between glutamate antagonists and dopamine agonists are complex and depend on the receptor selectivities of the drugs concerned. The manner of the interaction between these glutamate antagonists and selective D1 or D2 agonists, is not predictive of the way that blockade of glutamate transmission interferes with the actions of drugs which have combined D1 and D2 motor stimulant properties.

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“…In other words, the reserpinized controls, although weighing less than the vehicle-treated rats, exhibited considerably more locomotor activity than the vehicle controls. With this finding in mind, it seems likely that repeated reserpine treatment caused receptor supersensitivity (Rubinstein et al 1990;LaHoste and Marshall 1992;LaHoste et al 1993), which was expressed as a general increase in locomotion that was apparent in the various reserpine-terguride and reserpine-saline groups on PD 21 (see Rubinstein et al 1988). Receptor supersensitivity may also explain why the AMPT-saline group had greater distance-traveled scores than the vehicle-saline group on PD 21.…”

Section: Discussionmentioning

confidence: 81%

The partial dopamine D2-like receptor agonist terguride functions as an agonist in preweanling rats after a 5-day reserpine regimen

et al. 2006

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Different roles of D-1 and D-2 dopamine receptors involved in locomotor activity of supersensitive mice

Cited by 45 publications

References 19 publications

Interactions between histamine H3 and dopamine D2 receptors and the implications for striatal function

Interactions between histamine H3 and dopamine D2 receptors and the implications for striatal function

Glutamate antagonists modify the motor stimulant actions of D1 and D2 agonists in reserpine-treated mice in complex ways that are not predictive of their interactions with the mixed D1/D2 agonist apomorphine

The partial dopamine D2-like receptor agonist terguride functions as an agonist in preweanling rats after a 5-day reserpine regimen

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