Different Roles for VIP Neurons in the Neonatal and Adult Suprachiasmatic Nucleus

Mazuski, Cristina; Chen, Samantha P; Herzog, Erik D.

doi:10.1177/0748730420932073

Cited by 23 publications

(15 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To be clear, our findings do not argue against an important role for VIP signaling (VIP ligand and VIP receptors) per se; rather, the results presented here demonstrate that circadian function derived from Bmal1-dependent autonomous rhythms in AVP neurons is more impactful than that seen in VIP neurons. Our findings are consistent with a report that suggests that circadian function in VIP neurons is not essential for SCN or behavioral rhythmicity (Mazuski et al, 2020). Ultimately, further study of the electrical interaction of these neurotransmitters is needed to understand communication in the SCN (Hastings et al, 2018;Honma, 2018).…”

Section: Discussionsupporting

confidence: 91%

Dual-Color Single-Cell Imaging of the Suprachiasmatic Nucleus Reveals a Circadian Role in Network Synchrony

Shan

Abel

et al. 2020

Neuron

View full text Add to dashboard Cite

The suprachiasmatic nucleus (SCN) acts as a master pacemaker driving circadian behavior and physiology. Although the SCN is small, it is composed of many cell types, making it difficult to study the roles of particular cells. Here we develop bioluminescent circadian reporter mice that are Cre dependent, allowing the circadian properties of genetically defined populations of cells to be studied in real time. Using a Color-Switch PER2::-LUCIFERASE reporter that switches from red PER2::LUCIFERASE to green PER2::LUCIFERASE upon Cre recombination, we assess circadian rhythms in two of the major classes of peptidergic neurons in the SCN: AVP (arginine vasopressin) and VIP (vasoactive intestinal polypeptide). Surprisingly, we find that circadian function in AVP neurons, not VIP neurons, is essential for autonomous network synchrony of the SCN and stability of circadian rhythmicity.

show abstract

Section: Discussionsupporting

confidence: 91%

Dual-Color Single-Cell Imaging of the Suprachiasmatic Nucleus Reveals a Circadian Role in Network Synchrony

Shan

Abel

et al. 2020

Neuron

View full text Add to dashboard Cite

show abstract

“…VIP neurons are suggested to be important for the maturation of neuronal networks in the SCN during development. Ablation of VIP neurons in the adult SCN using AAV-mediated expression of caspase3 induced shortening of circadian behavioral rhythms ( Mazuski et al, 2020 ), but only 15% of mice became behaviorally arrhythmic. In contrast, 50% of the mice were arrhythmic when VIP or VPAC2 was deleted globally.…”

Section: Neuropeptide-related Neuronal Network In the Suprachiasmatic Nucleus During Developmentmentioning

confidence: 99%

“…In contrast, 50% of the mice were arrhythmic when VIP or VPAC2 was deleted globally. In addition, ablation of VIP neurons in the neonatal SCN significantly dampens the circadian PER2:LUC rhythm ( Mazuski et al, 2020 ). These results suggest that VIP neurons are important for synchrony in the SCN during early development but not in adulthood.…”

Section: Neuropeptide-related Neuronal Network In the Suprachiasmatic Nucleus During Developmentmentioning

confidence: 99%

Roles of Neuropeptides, VIP and AVP, in the Mammalian Central Circadian Clock

Ono

Honma

2021

Front. Neurosci.

View full text Add to dashboard Cite

In mammals, the central circadian clock is located in the suprachiasmatic nucleus (SCN) of the hypothalamus. Individual SCN cells exhibit intrinsic oscillations, and their circadian period and robustness are different cell by cell in the absence of cellular coupling, indicating that cellular coupling is important for coherent circadian rhythms in the SCN. Several neuropeptides such as arginine vasopressin (AVP) and vasoactive intestinal polypeptide (VIP) are expressed in the SCN, where these neuropeptides function as synchronizers and are important for entrainment to environmental light and for determining the circadian period. These neuropeptides are also related to developmental changes of the circadian system of the SCN. Transcription factors are required for the formation of neuropeptide-related neuronal networks. Although VIP is critical for synchrony of circadian rhythms in the neonatal SCN, it is not required for synchrony in the embryonic SCN. During postnatal development, the clock genes cryptochrome (Cry)1 and Cry2 are involved in the maturation of cellular networks, and AVP is involved in SCN networks. This mini-review focuses on the functional roles of neuropeptides in the SCN based on recent findings in the literature.

show abstract

“…Although VIP is also expressed through out other parts of the mammalian brain such as cortex, retina, and superior colliculus, a recent study by Mazuski et al shows that VIP from the SCN is crucial in sustaining daily rhythms synchronization. Therefore, VIP has been hypothesized to be necessary for the intra-SCN connectivity and generation of the SCN output to hypothalamic areas 54 . In accord with the implications of these findings, our model predicts that keeping VIP coupling strength above a minimum value inside the SCN is crucial for maintaining the rhythmicity throughout the system.…”

Section: Discussionmentioning

confidence: 99%

Light entrainment of the SCN circadian clock and implications for personalized alterations of corticosterone rhythms in shift work and jet lag

Androulakis

2021

Sci Rep

View full text Add to dashboard Cite

The suprachiasmatic nucleus (SCN) functions as the central pacemaker aligning physiological and behavioral oscillations to day/night (activity/inactivity) transitions. The light signal entrains the molecular clock of the photo-sensitive ventrolateral (VL) core of the SCN which in turn entrains the dorsomedial (DM) shell via the neurotransmitter vasoactive intestinal polypeptide (VIP). The shell converts the VIP rhythmic signals to circadian oscillations of arginine vasopressin (AVP), which eventually act as a neurotransmitter signal entraining the hypothalamic–pituitary–adrenal (HPA) axis, leading to robust circadian secretion of glucocorticoids. In this work, we discuss a semi-mechanistic mathematical model that reflects the essential hierarchical structure of the photic signal transduction from the SCN to the HPA axis. By incorporating the interactions across the core, the shell, and the HPA axis, we investigate how these coupled systems synchronize leading to robust circadian oscillations. Our model predicts the existence of personalized synchronization strategies that enable the maintenance of homeostatic rhythms while allowing for differential responses to transient and permanent light schedule changes. We simulated different behavioral situations leading to perturbed rhythmicity, performed a detailed computational analysis of the dynamic response of the system under varying light schedules, and determined that (1) significant interindividual diversity and flexibility characterize adaptation to varying light schedules; (2) an individual’s tolerances to jet lag and alternating shift work are positively correlated, while the tolerances to jet lag and transient shift work are negatively correlated, which indicates trade-offs in an individual’s ability to maintain physiological rhythmicity; (3) weak light sensitivity leads to the reduction of circadian flexibility, implying that light therapy can be a potential approach to address shift work and jet lag related disorders. Finally, we developed a map of the impact of the synchronization within the SCN and between the SCN and the HPA axis as it relates to the emergence of circadian flexibility.

show abstract

Different Roles for VIP Neurons in the Neonatal and Adult Suprachiasmatic Nucleus

Cited by 23 publications

References 38 publications

Dual-Color Single-Cell Imaging of the Suprachiasmatic Nucleus Reveals a Circadian Role in Network Synchrony

Dual-Color Single-Cell Imaging of the Suprachiasmatic Nucleus Reveals a Circadian Role in Network Synchrony

Roles of Neuropeptides, VIP and AVP, in the Mammalian Central Circadian Clock

Light entrainment of the SCN circadian clock and implications for personalized alterations of corticosterone rhythms in shift work and jet lag

Contact Info

Product

Resources

About