Different Relationships between FENO and COPD Characteristics in Smokers and Ex-Smokers

Högman, Marieann; Thornadtsson, Alexandra; Bröms, Kristina; Janson, Christer; Lisspers, Karin; Ställberg, Björn; Hedenström, Hans; Malinovschi, Andreï

doi:10.1080/15412555.2019.1638355

Cited by 11 publications

(12 citation statements)

References 40 publications

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“…ICS therapy has been shown to influence F E NO 50 levels in some 30,31 but not all 32 studies. Similarly, the relationship between ICS and blood and/or sputum eosinophil count appears to be ambiguous in COPD patients: some investigators documented no difference between ICS users and non-users 6 while others found reduced eosinophil counts as a result of ICS treatment.…”

Section: Discussionmentioning

confidence: 98%

Predictive Value of Exhaled Nitric Oxide and Blood Eosinophil Count in the Assessment of Airway Eosinophilia in COPD

Antus

Páska

Barta

2020

COPD

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Fractional exhaled nitric oxide (F E NO 50) level and peripheral blood eosinophil count may serve as indicators of airway eosinophilia. The aim of this study was to estimate the diagnostic value of these markers for detecting airway eosinophilia in patients with stable chronic obstructive pulmonary disease (COPD) and those experiencing an acute exacerbation (AECOPD). Patients and Methods: F E NO 50 levels, sputum and blood eosinophil counts were assessed in 53 clinically stable ex-smoker COPD patients and 67 ex-smoker COPD patients experiencing a severe exacerbation. In AECOPD, clinical variables were measured at the time of hospital admission and discharge following treatment. Results: In stable COPD, blood eosinophil count but not F E NO 50 level was found to be a good predictor of airway eosinophilia (area under the receiver operating characteristic curve [ROC AUC]: ≥0.82). The sensitivity and the specificity of the test ranged between 75% and 98%, the negative predictive value (NPV) was high (>90%). In AECOPD, F E NO 50 was predictive for airway eosinophilia (ROC AUC: >0.8) with high NPV (>88%), but with lower sensitivity and specificity (64-70%). In contrast, the predictive accuracy of blood eosinophil count for airway eosinophilia in AECOPD was modest (ROC AUC: 0.54-0.63). The combined use of the two markers provided only limited additional benefit. Correlation analyses supported ROC curve findings. Conclusion: In stable COPD the peripheral blood eosinophil count, while in AECOPD the F E NO 50 level is a good surrogate marker of airway eosinophilia.

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Section: Discussionmentioning

confidence: 98%

Predictive Value of Exhaled Nitric Oxide and Blood Eosinophil Count in the Assessment of Airway Eosinophilia in COPD

Antus

Páska

Barta

2020

COPD

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“… 37 , 38 Furthermore, FeNO values were lower among current smokers, a finding consistent with existing literature. 39 However, all FeNO values fell well below 25 ppb, which is the threshold indicating airway inflammation. 40 …”

Section: Discussionmentioning

confidence: 94%

Cross-sectional Study of Workers Employed at a Copper Smelter—Effects of Long-term Exposures to Copper on Lung Function and Chronic Inflammation

Haase

Birk

Poland

et al. 2022

J Occup Environ Med

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“…The FeNO measurement was considered to be a biomarker for airway eosinophilic inflammation ( Zhou et al, 2020 ), because its concentration is highly correlated with the number of inflammatory cells ( Hogman et al, 2019 ). In this study, subgroup analysis was performed according to FeNO, and the difference was not statistically significant ( P > 0.05).…”

Section: Discussionmentioning

confidence: 99%

Comparison of Immediate and Sequential Withdrawal of a Systemic Glucocorticoid in the Treatment of Acute Exacerbations of Chronic Obstructive Pulmonary Disease: A Multicenter, Randomized, Double-Blind, Parallel-Controlled, Open-Label Study

Zhou

Fang

Liu

et al. 2021

Front. Mol. Biosci.

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Patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD) were treated with immediate or sequential withdrawal after 5 days of systemic glucocorticoids. The effects of the two withdrawal methods on the prognosis of patients were compared at 30, 90, 180, and 360 days after discharge. A multicenter, randomized, double-blind, parallel-controlled, open-label study was conducted in the respiratory department of tertiary hospitals in Central China. Patients met inclusion criteria for AECOPD and needed to use systemic glucocorticoids. They were randomly assigned to immediate and sequential withdrawal groups at a 1:1 ratio. The study was completed in August 2020 and is registered at the China Clinical Trials Registry (Chictr.org) (ChiCTR1800018894). According to general data and clinical characteristics, there were no statistically significant differences between the 329 patients in the immediate withdrawal group and the 310 patients in the sequential withdrawal group (P > 0.05). At the 30, 90, 180, and 360-days follow-up, the acute exacerbation frequency, rehospitalization rate, mortality, and intensive care unit (ICU) treatment rate were not significantly different between the immediate withdrawal group and sequential withdrawal group (P > 0.05). The modified Medical Research Council (mMRC) and COPD assessment test (CAT) scores were also not significantly different between the two groups. At the 180- and 360-day follow-up, forced expiratory volume in 1 s (FEV1%) and peak expiratory flow (PEF) were not significantly different between the two groups (P > 0.05). The time from discharge to first acute exacerbation was significantly lower in the immediate withdrawal group (46.12 days) than in sequential withdrawal group (49.02 days) (P < 0.05). The time of stay in the hospital for the first time after discharge was not significantly different between the two groups (P > 0.05). Adverse events were not significantly different between the immediate withdrawal group and sequential withdrawal group (P < 0.05). Subgroup analysis was performed according to age, degree of disease, and relevant indicators. At the 30-day follow-up, the acute exacerbation frequency of patients with advanced age, high global strategy for chronic obstructive lung disease (GOLD), and high fractional exhaled nitric oxide was significantly higher in the immediate withdrawal group than in the sequential withdrawal group (P < 0.05). In addition, according to receiver operating characteristic (ROC) curve analysis, the frequency of acute exacerbations at the 30-day follow-up was significantly higher in patients with age > 63.5 years or GOLD > 3 in the immediate withdrawal group than in the sequential withdrawal group, suggesting that the short-term efficacy was poor.

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Different Relationships between F_ENO and COPD Characteristics in Smokers and Ex-Smokers

Cited by 11 publications

References 40 publications

<p>Predictive Value of Exhaled Nitric Oxide and Blood Eosinophil Count in the Assessment of Airway Eosinophilia in COPD</p>

<p>Predictive Value of Exhaled Nitric Oxide and Blood Eosinophil Count in the Assessment of Airway Eosinophilia in COPD</p>

Cross-sectional Study of Workers Employed at a Copper Smelter—Effects of Long-term Exposures to Copper on Lung Function and Chronic Inflammation

Comparison of Immediate and Sequential Withdrawal of a Systemic Glucocorticoid in the Treatment of Acute Exacerbations of Chronic Obstructive Pulmonary Disease: A Multicenter, Randomized, Double-Blind, Parallel-Controlled, Open-Label Study

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