Different Protection Rates in Various Groups of Volunteers Given Subunit Influenza Virus Vaccine in 1976

Feery, Brian J.; Evered, Maurice G.; Morrison, Edna I.

doi:10.1093/infdis/139.2.237

Cited by 72 publications

(26 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nine studies (38 influenza seasons, 13,373 participants) assessed influenza rates in HCWs [9], [19], [20], [27]–[29], [36], [40], [41], seven studies (20 influenza seasons, 3,642 participants) enrolled families with children [5], [21]–[24], [26], [31], and 14 studies (39 influenza seasons, 41,230 participants) assessed influenza rates in adults not working in healthcare settings and irrespective of family status [15]–[18], [20], [25], [30], [32]–[35], [37]–[39]. From these, one study provided data for both HCWs and non-HCWs without comparison [20]. One other study compared HCWs to non-HCWs directly, but the non-HCW group did not fit our inclusion and exclusion criteria as college students were included in the non-HCW group [9].…”

Section: Resultsmentioning

confidence: 99%

Incidence of Influenza in Healthy Adults and Healthcare Workers: A Systematic Review and Meta-Analysis

et al. 2011

View full text Add to dashboard Cite

BackgroundWorking in healthcare is often considered a risk factor for influenza; however, this risk has not been quantified. We aimed to systematically review evidence describing the annual incidence of influenza among healthy adults and healthcare workers (HCWs).Methods and FindingsWe searched OVID MEDLINE (1950 to 2010), EMBASE (1947 to 2010) and reference lists of identified articles. Observational studies or randomized trials reporting full season or annual influenza infection rates for healthy, working age adult subjects and HCWs were included. Influenza infection was defined as a four-fold rise in antibody titer, or positive viral culture or polymerase chain reaction.From 24,707 citations, 29 studies covering 97 influenza seasons with 58,245 study participants were included. Pooled influenza incidence rates (IR) (95% confidence intervals (CI)) per 100 HCWs per season and corresponding incidence rate ratios (IRR) (95% CI) as compared to healthy adults were as follows. All infections: IR 18.7 (95% CI, 15.8 to 22.1), IRR 3.4 (95% CI, 1.2 to 5.7) in unvaccinated HCWs; IR 6.5 (95% CI, 4.6 to 9.1), IRR 5.4 (95% CI, 2.8 to 8.0) in vaccinated HCWs. Symptomatic infections: IR 7.5 (95% CI, 4.9 to 11.7), IRR 1.5 (95% CI, 0.4 to 2.5) in unvaccinated HCWs, IR 4.8 (95% CI, 3.2 to 7.2), IRR 1.6 (95% CI, 0.5 to 2.7) in vaccinated HCWs.ConclusionsCompared to adults working in non-healthcare settings, HCWs are at significantly higher risk of influenza.

show abstract

Section: Resultsmentioning

confidence: 99%

Incidence of Influenza in Healthy Adults and Healthcare Workers: A Systematic Review and Meta-Analysis

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Unfortunately, antibody responses to influenza virus in elderly persons show reduced levels of both IgG and IgA antibodies, delayed peak antibody titers, and shorter maintenance of antibody titers (8,13,23). Studies with rodents indicate that during aging a progressively increasing proportion of nonfunctional cells results in decreased T-cell proliferation, IL-2 production, and cytotoxicity (33).…”

Section: Vol 78 2004 Lt-is Patch Enhances Influenza Virus Vaccinatimentioning

confidence: 99%

Immunostimulant Patch Enhances Immune Responses to Influenza Virus Vaccine in Aged Mice

Guebre‐Xabier

Hammond

Ellingsworth

et al. 2004

J Virol

View full text Add to dashboard Cite

Improvement in the immune response to influenza virus vaccination in the elderly represents the primary unmet need in influenza virus vaccination. We have shown that topical application of immunostimulating (IS) patches containing heat-labile enterotoxin of Escherichia coli (LT) enhances immune responses to injected vaccines. We extend these findings and show that LT-IS patch application enhances the antibody responses to influenza virus vaccination in both young and aged mice. LT-IS patches markedly increased influenza virusspecific immunoglobulin G (IgG), hemagglutination inhibition antibody, mucosal antibody, and T-cell responses. The magnitude of the immune responses in aged mice receiving an LT-IS patch was equivalent to or greater than that of the immune responses in young mice given vaccine alone. These results suggest that addition of an LT-IS patch may compensate for the deficient immune function seen in the aged in response to influenza virus vaccination. Therefore, use of an LT-IS patch could be a new, safe, and simple immunization strategy that may significantly improve the outcome of influenza virus vaccination in the elderly.

show abstract

“…1). 66,67 Third, health care workers have frequent contact with patients at high risk for complications from influenza and may transmit influenza to susceptible patients, resulting in increased patient morbidity and mortality. Improved health care worker vaccination rates have been linked with decreased health care–associated influenza among patients and personnel 68.…”

Section: Seasonal Influenzamentioning

confidence: 99%

Health Care–Acquired Viral Respiratory Diseases

Goins¹,

Talbot²,

Talbot³

2011

Infectious Disease Clinics of North America

View full text Add to dashboard Cite

Health care–associated viral respiratory infections, common among hospitalized children, also occur among adults and institutionalized persons and result in increased patient morbidity, mortality, and health care costs. Approximately 20% of patients with health care–associated pneumonia have viral respiratory infections, with 70% of these infections caused by adenovirus, influenza virus, parainfluenza virus, and respiratory syncytial virus (RSV).1 These infections typically reflect the level of viral activity within the community.1,2 This article focuses on the epidemiology, transmission, and control of health care–associated RSV and influenza virus.

show abstract

Different Protection Rates in Various Groups of Volunteers Given Subunit Influenza Virus Vaccine in 1976

Cited by 72 publications

References 12 publications

Incidence of Influenza in Healthy Adults and Healthcare Workers: A Systematic Review and Meta-Analysis

Incidence of Influenza in Healthy Adults and Healthcare Workers: A Systematic Review and Meta-Analysis

Immunostimulant Patch Enhances Immune Responses to Influenza Virus Vaccine in Aged Mice

Health Care–Acquired Viral Respiratory Diseases

Contact Info

Product

Resources

About