2016
DOI: 10.1002/gcc.22381
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Different prognostic roles of tumor suppressor gene BAP1 in cancer: A systematic review with meta‐analysis

Abstract: Biallelic inactivation of the tumor suppressor gene BRCA1-associated protein 1 (BAP1) has been demonstrated in several cancers, but its prognostic role has not been completely explained. We aimed to investigate the risk associated with loss of BAP1 (BAP1-) for all-cause mortality, cancer-specific mortality and recurrence of disease in subjects with cancer. PubMed and SCOPUS were searched from database inception until 09/15/2015 without language restrictions. Prospective studies reporting data on prognostic par… Show more

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Cited by 59 publications
(48 citation statements)
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“…A recent meta-analysis has shown that somatic alterations in BAP1 gene are associated with poor prognosis in many cancers, except for MM. 31 In our series, subjects with BAP1-negative MM had a slightly but not significant longer survival than subject with BAP1-positive MM (13.5 months, data not shown).…”
Section: Discussionmentioning
confidence: 44%
“…A recent meta-analysis has shown that somatic alterations in BAP1 gene are associated with poor prognosis in many cancers, except for MM. 31 In our series, subjects with BAP1-negative MM had a slightly but not significant longer survival than subject with BAP1-positive MM (13.5 months, data not shown).…”
Section: Discussionmentioning
confidence: 44%
“…Biallelic inactivation of the tumor suppressor gene BRCA1-associated protein 1 (BAP1) occurs in several cancers (colorectal, renal and malignant mesothelioma). BAP1 deletion on staining and immunohistochemistry is the latest discovery, of special interest to the pathologist, and a very useful marker for a definitive diagnosis of malignant mesothelioma distinguishing it from atypical reactive mesothelial proliferations in effusions [5,6]. Presence of BAP1 deletion increases cancer-specific mortality and risk of recurrence in all cancers, except mesothelioma, where it correlates with a better prognosis [7].…”
Section: Discussionmentioning
confidence: 99%
“…Interestingly, current or former smokers with MPM appear more likely to have somatic BAP1 mutations, although nucleotide substitutions do not suggest a direct causal role of smoker exposure and BAP1 mutations (98). Additionally, in contrast to EZH2 or SUZ12 over-expression which appears to be associated with decreased patient survival, BAP1 mutations appear be associated with improved patient survival despite upregulation of both of these PRC-2 components (99,100). This paradox may be related to deficient BRCA-1-mediated DNA repair, which may render BAP1 mutant MPM cells more sensitive to DNA damaging agents.…”
Section: Polycomb Mediated Gene Silencingmentioning
confidence: 90%