Different priming techniques, including mivacurium, accelerate the onset of rocuronium

Abstract

(73 (57-90) sec) or mivacurium (58 (47-69) sec) were similar to those after succinylcholine (54 (40-68) sec), and were shorter (P < 0.01)

A Study of Priming Technique of Rocuronium in Facilitating Intubation

“…In addition, propofol was reported to produce significant depression of laryngeal reflexes 11 . In the previous studies, Griffith et al 6 and Yavascaoglu et al 9 induced anaesthesia with midazolam, fentanyl and propofol and also used 60% N20 in oxygen until tracheal intubation and additional doses of thiopentone 8 or propofol 9 were used as needed prior to tracheal intubation. On the other hand, in this study, we used thiopental sodium, the commonly used induction agent in our country and neither additional dose of TPS nor any inhalational agent except oxygen was used prior to tracheal intubation.…”

A priming technique accelerates onset of neuromuscular blockade at the laryngeal adductor muscles

“…They found that priming with a threeminute interval shortened the onset time of rocuronium irrespectively of the dosage, while a two-minute priming interval did not significantly decrease the onset time. Naguib et al 9 could also demonstrate that priming three minutes prior to an intubation dose significantly shortened the onset time at the AP.…”

“…Priming with rocuronium has been shown to shorten onset of neuromuscular blockade (NMB) at the AP. [6][7][8][9] The laryngeal muscles are important because they play a pivotal role in airway maintenance and protection. We know that the time course and potency of muscle relaxants differ at the laryngeal muscles as compared with the AP.…”

“…However, there are several studies which have shown that priming does not prolong the clinical duration of NMB in comparison to a non-priming technique. 8,9,12 We deliberately chose a priming interval of three minutes since the size of the priming and intubation dose as well as the priming interval are important for the effect of the priming technique. Yavascaoglu et al 13 studied different priming intervals (two and three minutes) and priming dosages (priming dose: rocuronium 0.06 or 0.1 mg·kg -1 , intubation dose 0.54 or 0.5 mg·kg -1 ).…”

Pharmacoeconomics and Pharmacodynamic Interactions of Rocuronium and Pancuronium

“…However, the results are unequivocal and sometimes even contradictory regarding the interaction among various neuromuscular agents, that is, whether they are additive or synergistic. Structurally dissimilar neuromuscular blocking drugs were shown to result in a potentiating effects as seen with combination of rocuronium and mivacurium [11][12][13][14][15][16][17], rocuronium and cis-atracurium [18,19], and mivacurium and pancuronium [20][21][22]. It was earlier proposed that combinations of structurally similar neuromuscular blocking drugs produce an additive response in humans.…”