Different prevalence of T2DM risk alleles in Roma population in comparison with the majority Czech population

Hubáček, J.; Šedová, Lenka; Olišarová, Věra; Adámková, Věra; Tóthová, Valérie

doi:10.1002/mgg3.1361

Cited by 11 publications

(5 citation statements)

References 53 publications

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“…In addition to environmental and lifestyle factors, it seems that genetic reasons are behind the differences in the frequency of CVD risk factors between Roma and non-Roma populations. Recent research has shown that the increased prevalence of diabetes in Czech Roma [52], as well as the increased average BMI and waist circumference [53] and the reduced prevalence of hypertension [54] in the Hungarian Roma population, may be associated with different frequencies of the risk alleles in genes associated with the development of these phenotypes. Some of the SNPs investigated in these studies have been identified as potentially useful for assessing genetic risk score in the Roma population.…”

Section: Discussionmentioning

confidence: 99%

CVD Risk Factors in the Ukrainian Roma and Meta-Analysis of Their Prevalence in Roma Populations Worldwide

Petranović

Rizzieri

Sivaraj

et al. 2021

JPM

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The Roma population suffers from severe poverty, social exclusion, and some of the worst health conditions in the industrialized world. Herein, we report on cardiovascular disease (CVD) risk factors in the Ukrainian Roma and present a meta-analysis of the prevalence of CVD risk factors in 16 Roma populations worldwide. The meta-analyses of CVD risk factors in Roma (n = 16,552) vs. non-Roma majority population of the same country (n = 127,874) included publicly available data. Ukrainian field survey included 339 adults of both sexes and outcomes of interest were hypertension, body mass index (BMI), smoking, education, and employment status. Furthermore, 35.7% of the Ukrainian Roma were hypertensive, 69.3% unemployed, and 48.4% never went to school. Ukrainian Roma women were more likely to be underweight and more prone to be hypertensive, with odds of hypertension increasing with age, BMI, and positive smoking status. Meta-analyses showed that, in comparison with non-Roma worldwide, the Roma bear significantly higher risk factor loads related to smoking (OR = 2.850), diabetes (OR = 1.433), abdominal obesity (OR = 1.276), and metabolic syndrome (OR = 1.975), with lower loads for hypertension (OR = 0.607) and BMI ≥ 25 kg/m2 (OR = 0.872). To conclude, the CVD risk factors which are more common in Roma than in the majority population may reflect their poor health-related behaviors and inadequate access to health education.

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Section: Discussionmentioning

confidence: 99%

CVD Risk Factors in the Ukrainian Roma and Meta-Analysis of Their Prevalence in Roma Populations Worldwide

Petranović

Rizzieri

Sivaraj

et al. 2021

JPM

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“…The Roma people (historically referred to as "gypsies") in Europe emigrated from northern South Asia during the eleventh century. It is interesting to note that the Roma peoples' rates of diabetes are similar to or significantly higher than rates of diabetes among white Caucasians [113][114][115][116][117]. However, reports of increased prevalence of diabetes among Roma populations are thought to occur due to predisposing factors of lower socioeconomic status, and increased smoking rates of the Roma people compared with the general population who on average have higher socioeconomic status [117][118][119].…”

Section: A Pre-colonial South Asian Historical Control Populationmentioning

confidence: 96%

The Susceptibility of South Asians to Cardiometabolic Disease as a Result of Starvation Adaptation Exacerbated During the Colonial Famines

2022

Endocrinol Diabetes Metab J

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South Asians, representing one quarter of the world's population, have disproportionally high rates of obesity and cardiometabolic disease thus resulting an epidemic health crisis. This crisis could be the consequence of epigenetic effects exacerbated during the colonial-era famines resulting in a unique starvation-adapted physiology. Due to evolutionary mismatch in circumstances of abundance, this starvation-adapted physiology can become harmful. Evidence for this starvation adaptation in South Asians includes high body fat and unfavorable adipokines; low lean body mass; lower resting energy expenditure (compounded by lack of brown adipose tissue); greater insulin resistance and insulin response; exaggerated lipemic response to fat and sugar intake; less capacity to handle an overabundance of food; lower fat burning (oxidative capacity) and VO2max during aerobic exercise; and energyconserving response to resistance exercise, as well as increased lipoprotein (a) levels. The Roma people, also of South Asian ancestry, may represent an interesting pre-colonial historical control. Physician and patient knowledge of this unique physiology in South Asians will promote a stronger physicianpatient relationship and foster compliance with treatment.

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“…The largest Middle European minority are Roma/Gypsy subjects, exhibiting identical ethnicity as the majority—Caucasians. Between Roma Caucasians and non-Roma Caucasians, significant differences were described (not only) in genetic predisposition to T2DM, albeit in both directions depending on the set of SNPs selected [ 138 , 139 ].…”

Section: Geographical and Ethnical Differencesmentioning

confidence: 99%

Genetics of Cardiovascular Disease: How Far Are We from Personalized CVD Risk Prediction and Management?

Vráblík

Dlouhá

Todorovová

et al. 2021

IJMS

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Despite the rapid progress in diagnosis and treatment of cardiovascular disease (CVD), this disease remains a major cause of mortality and morbidity. Recent progress over the last two decades in the field of molecular genetics, especially with new tools such as genome-wide association studies, has helped to identify new genes and their variants, which can be used for calculations of risk, prediction of treatment efficacy, or detection of subjects prone to drug side effects. Although the use of genetic risk scores further improves CVD prediction, the significance is not unambiguous, and some subjects at risk remain undetected. Further research directions should focus on the “second level” of genetic information, namely, regulatory molecules (miRNAs) and epigenetic changes, predominantly DNA methylation and gene-environment interactions.

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Different prevalence of T2DM risk alleles in Roma population in comparison with the majority Czech population

Cited by 11 publications

References 53 publications

CVD Risk Factors in the Ukrainian Roma and Meta-Analysis of Their Prevalence in Roma Populations Worldwide

CVD Risk Factors in the Ukrainian Roma and Meta-Analysis of Their Prevalence in Roma Populations Worldwide

The Susceptibility of South Asians to Cardiometabolic Disease as a Result of Starvation Adaptation Exacerbated During the Colonial Famines

Genetics of Cardiovascular Disease: How Far Are We from Personalized CVD Risk Prediction and Management?

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