Different Plasticity Patterns of Language Function in Children With Perinatal and Childhood Stroke

Ilves, Pilvi; Tomberg, Tiiu; Kepler, J; Laugesaar, Rael; Kaldoja, Mari-Liis; Kepler, Kalle; Kolk, Anneli

doi:10.1177/0883073813489350

Cited by 51 publications

(59 citation statements)

References 37 publications

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“…Increased connectivity of the networks outside the region of primary damage (DMN) can be a compensatory effect occurring after cortical brain damage in children with AIS due to brain's plasticity; in this case areas outside the lost tissue take over its functions. A similar finding was obtained by a task-based fMRI [20, 21]. The prefrontal regions, both ipsi- and contralateral to the lesion, were activated in patients but not in controls after language and visual search tasks, which may compensate for lost functions according to task-based fMRI [20].…”

Section: Discussionsupporting

confidence: 70%

“…Ischemic stroke was classified as AIS or PVI using the criteria based on a previous study by Kirton and coworkers [4] and modified by Ilves and coworkers [3, 21]. Patients were only considered eligible for our preliminary study when (a) they had documented unilateral left-hemisphere AIS or PVI (for the sake of homogeneity in the study as perinatal stoke affects more often the left side according to previous studies [18]) but also in our database (68%); (b) they were aged 7–17; and (c) they were able to remain still for about 45 minutes without sedation and to follow instructions during the MRI investigation.…”

Section: Methodsmentioning

confidence: 99%

“…Task-based functional magnetic resonance imaging (fMRI) is used to investigate separate functions like motor [19] and language [20, 21] functions in stroke children. The fMRI has revealed the functional plasticity of the brain in the case of focal brain damage in perinatal stroke patients [19, 21].…”

Section: Introductionmentioning

confidence: 99%

“…The fMRI has revealed the functional plasticity of the brain in the case of focal brain damage in perinatal stroke patients [19, 21]. However, task-based studies present several challenges for stroke patients, including motor task-related motion artifacts, inconsistent performance, mirror movements, or individual ability to perform the task altogether [22].…”

Section: Introductionmentioning

confidence: 99%

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Resting-State Functional Connectivity and Cognitive Impairment in Children with Perinatal Stroke

Ilves

Laugesaar

et al. 2016

Neural Plasticity

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Perinatal stroke is a leading cause of congenital hemiparesis and neurocognitive deficits in children. Dysfunctions in the large-scale resting-state functional networks may underlie cognitive and behavioral disability in these children. We studied resting-state functional connectivity in patients with perinatal stroke collected from the Estonian Pediatric Stroke Database. Neurodevelopment of children was assessed by the Pediatric Stroke Outcome Measurement and the Kaufman Assessment Battery. The study included 36 children (age range 7.6–17.9 years): 10 with periventricular venous infarction (PVI), 7 with arterial ischemic stroke (AIS), and 19 controls. There were no differences in severity of hemiparesis between the PVI and AIS groups. A significant increase in default mode network connectivity (FDR 0.1) and lower cognitive functions (p < 0.05) were found in children with AIS compared to the controls and the PVI group. The children with PVI had no significant differences in the resting-state networks compared to the controls and their cognitive functions were normal. Our findings demonstrate impairment in cognitive functions and neural network profile in hemiparetic children with AIS compared to children with PVI and controls. Changes in the resting-state networks found in children with AIS could possibly serve as the underlying derangements of cognitive brain functions in these children.

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Section: Discussionsupporting

confidence: 70%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Resting-State Functional Connectivity and Cognitive Impairment in Children with Perinatal Stroke

Ilves

Laugesaar

et al. 2016

Neural Plasticity

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“…Besides hemiparesis, [4][5][6] survivors may manifest neurocognitive deficits, 7 language impairment, 8 or behavioral disorders and epilepsy, 3,9 often with emerging deficits during the school years. 10 Perinatal ischemic stroke is a group of heterogeneous conditions involving focal disruption of cerebral blood flow secondary to arterial or venous thrombosis or embolization.…”

mentioning

confidence: 99%

Presumed Perinatal Stroke

et al. 2015

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It is unknown why some infants with perinatal stroke present clinical symptoms late during infancy and will be identified as infants with presumed perinatal stroke. The risk factors and clinical and radiological data of 42 infants with presumed perinatal stroke (69% with periventricular venous infarction and 31% with arterial ischemic stroke) from the Estonian Pediatric Stroke Database were reviewed. Children with presumed perinatal stroke were born at term in 95% of the cases and had had no risk factors during pregnancy in 43% of the cases. Children with periventricular venous infarction were born significantly more often (82%) vaginally (P = .0213) compared to children with arterial stroke (42%); nor did they require resuscitation (P = .0212) or had any neurological symptoms after birth (P = .0249). Periventricular venous infarction is the most common type of lesion among infants with the presumed perinatal stroke. Data suggest that the disease is of prenatal origin.

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