Different Patterns of Lung Sirtuin Expression in Smokers With and Without Chronic Obstructive Pulmonary Disease

Isajevs, Sergejs; Strazda, Gunta; Kopeika, Uldis; Taivāns, Immanuels

doi:10.3390/medicina48100080

Cited by 10 publications

(11 citation statements)

References 18 publications

(27 reference statements)

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“…It has been observed that in the large airways of COPD patients and smokers, Sirt1 expression was lower than in healthy people. On the contrary, in the small airways of COPD patients, a significant reduction of Sirt1 levels was found compared to the lung of smokers and healthy controls [89]. In addition, the exposure to chronic cigarette smoke, in COPD patients, enhanced matrix metallo-proteinases 2, 9 and 12 and this phenomenon was associated with low Sirt1 level too [90].…”

Section: The Involvement Of Sirtuins In Other Pathophysiological Condmentioning

confidence: 90%

“…Whether Sirt1 plays a role in this context remains to be determined. However, it must be noted, that different results have been obtained studying cells coming from large and small airways such as macrophages, lymphocytes and endothelial cells [89]. In a study, three groups of patients were compared: COPD smoker, smokers without COPD and healthy no-smokers.…”

Section: The Involvement Of Sirtuins In Other Pathophysiological Condmentioning

confidence: 99%

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Controversial Impact of Sirtuins in Chronic Non-Transmissible Diseases and Rehabilitation Medicine

Mongelli¹,

Gaetano²

2018

Preprint

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A large body of evidence report about the positive effects of physical activity in some pathophysiological conditions associated with age. Physical exercise alone or in combination with other medical therapies, unquestionably, causes reduction of symptoms in chronic non-transmissible diseases often leading to significant amelioration or complete healing. The molecular basis of this exciting therapeutic outcome, however, remain obscure. Epigenetics, exploring at the interface between the environment and the remodelling of chromatin structure, promises to shed light on this intriguing matter possibly contributing to the identification of novel therapeutic targets. In this review, we shall focalize on the role of class III histone deacetylases (HDACs), sirtuins (Sirts), which altered function has been frequently associated to the pathogenesis of aging-associated diseases including cancer, cardiovascular, muscular, neurodegenerative, bones and respiratory diseases, often with a controversial role. Numerous studies, in fact, demonstrate that Sirt-dependent pathways are activated upon physical and cognitive exercises linking the modulation of mitochondrial function, DNA structure and gene expression to designed medical therapies eventually leading to tangible beneficial outcomes. However, in similar conditions, other studies assign to sirtuins a negative pathophysiological role. Nevertheless, to study sirtuins in chronic diseases might lead to improve life quality in the elderly.

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Section: The Involvement Of Sirtuins In Other Pathophysiological Condmentioning

confidence: 90%

Section: The Involvement Of Sirtuins In Other Pathophysiological Condmentioning

confidence: 99%

Controversial Impact of Sirtuins in Chronic Non-Transmissible Diseases and Rehabilitation Medicine

Mongelli¹,

Gaetano²

2018

Preprint

View full text Add to dashboard Cite

show abstract

“…Whether Sirt1 plays a central role in this context remains to be determined. However, it must be noted that different results have been obtained studying cells coming from large and small airways such as macrophages, lymphocytes and endothelial cells [90]. In a study, the following groups of patients were compared: COPD smoker, smokers without COPD and healthy nonsmokers.…”

Section: The Involvement Of Sirtuins In Other Pathophysiological Condmentioning

confidence: 99%

Controversial Impact of Sirtuins in Chronic Non-Transmissible Diseases and Rehabilitation Medicine

Mongelli

Gaetano

2018

Preprint

View full text Add to dashboard Cite

A large body of evidence reports about the positive effects of physical activity in pathophysiological conditions associated with aging. Physical exercise, alone or in combination with other medical therapies, unquestionably causes reduction of symptoms in chronic non-transmissible diseases often leading to significant amelioration or complete healing. The molecular basis of this exciting outcome, however, remain largely obscure. Epigenetics, exploring at the interface between environmental signals and the remodelling of chromatin structure, promises to shed light on this intriguing matter possibly contributing to the identification of novel therapeutic targets. In this review, we shall focalize on the role of sirtuins (Sirts) a class III histone deacetylases (HDACs) which function has been frequently associated, often with a controversial role, to the pathogenesis of aging-associated pathophysiological conditions including cancer, cardiovascular, muscular, neurodegenerative, bones and respiratory diseases. Numerous studies, in fact, demonstrate that Sirt-dependent pathways are activated upon physical and cognitive exercises linking mitochondrial function, DNA structure remodelling and gene expression regulation to designed medical therapies leading to tangible beneficial outcomes. However, in similar conditions, other studies assign to sirtuins a negative pathophysiological role. In spite of this controversial effect, it is doubtless that studying sirtuins in chronic diseases might lead to an unprecedented improvement of life quality in the elderly.

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“…Using immunohistochemistry and western blotting, sirtuins were shown to be highly suppressed in large and small airways in human COPD, in which smoking led to suppression mainly in the large airways [38]. Epigenetic factors play a role in development of fibrosis [39].…”

Section: Sirtuins In Chronic Obstructive Pulmonary Diseasementioning

confidence: 99%

Histone deacetylases and their inhibitors

Royce

Karagiannis

2014

Current Opinion in Allergy &Amp; Clinical Immunology

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Important developments have been made in the understanding of histone deacetylase expression in normal and diseased airways and pulmonary tissue as well as effects of histone deacetylase inhibitors on structural and inflammatory cells in the lung, including cell proliferation, differentiation and apoptosis and senescence. Many of these discoveries may have implications in addressing airway inflammation, airway remodeling and airway hyperresponsiveness in asthma.

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Different Patterns of Lung Sirtuin Expression in Smokers With and Without Chronic Obstructive Pulmonary Disease

Cited by 10 publications

References 18 publications

Controversial Impact of Sirtuins in Chronic Non-Transmissible Diseases and Rehabilitation Medicine

Controversial Impact of Sirtuins in Chronic Non-Transmissible Diseases and Rehabilitation Medicine

Controversial Impact of Sirtuins in Chronic Non-Transmissible Diseases and Rehabilitation Medicine

Histone deacetylases and their inhibitors

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