Different patterns of functional and structural alterations of hippocampal sub-regions in subcortical vascular mild cognitive impairment with and without depression symptoms

Xu, Jinping; Wang, Jianjun; Lyu, Hanqing; Pu, Xuejia; Xu, Ziyun; Hu, Yuanming; Guo, Zengjun; Yu, Haibo; Hu, Qingmao

doi:10.1007/s11682-020-00321-7

Cited by 6 publications

(7 citation statements)

References 68 publications

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“…Several resting-state fMRI (rsfMRI) studies have shown that D-MCI patients exhibit distinct brain function changes from those with nD-MCI, such as differences in regional homogeneity in the cerebellum, superior medial prefrontal gyrus, and thalamus and differences in effective connectivity from the right amygdala to the right lingual and calcarine gyri and bilateral supplementary motor areas. [23][24][25][26] Using FC analysis with the amygdala as the seed point, our recent research showed that D-MCI patients exhibit significant FC abnormalities in the amygdala-medial prefrontal cortex and amygdala-sensorimotor networks. 27 The present study aimed to explore the FC characteristics between the HB and the whole-brain functional nerve nodes in patients with D-MCI.…”

Section: Introductionmentioning

confidence: 99%

“…Several resting‐state fMRI (rsfMRI) studies have shown that D‐MCI patients exhibit distinct brain function changes from those with nD‐MCI, such as differences in regional homogeneity in the cerebellum, superior medial prefrontal gyrus, and thalamus and differences in effective connectivity from the right amygdala to the right lingual and calcarine gyri and bilateral supplementary motor areas 23–26 …”

Section: Introductionmentioning

confidence: 99%

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Abnormal functional connectivity of the habenula in mild cognitive impairment patients with depression symptoms revealed by resting‐state functional magnetic resonance imaging

Cao

Chen

Xia

et al. 2023

Int J Geriat Psychiatry

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Background: Recent research suggests that abnormalities in the habenula (HB), a core area of the brain that transmits reward information, may be a determinant of depression. However, it is not clear whether the functional connectivity (FC) pattern of the mild cognitive impairment (MCI) with and without depression symptoms is abnormal. Methods:In this study, we used resting-state functional magnetic resonance imaging (fMRI) to examine the FC pattern of the HB in MCI patients with depression symptoms (D-MCI). We acquired fMRI data from 54 subjects on a 3T MRI. Subjects collected included 16 patients with D-MCI, 18 patients with MCI with no depression, and 20 healthy controls. One way ANCOVA and post hoc t-test were used to compare the difference in FC strength between the three groups. Results:The D-MCI group had altered FC between the left HB and the right superior temporal gyrus, right inferior frontal gyrus/opercular part, and right middle frontal gyrus. The D-MCI group had increased FC between the right HB and precuneus.Conclusions: These results suggest that the dysfunction of the HB-Default model network might be involved in the neural mechanism underlying depression in MCI.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Abnormal functional connectivity of the habenula in mild cognitive impairment patients with depression symptoms revealed by resting‐state functional magnetic resonance imaging

Cao

Chen

Xia

et al. 2023

Int J Geriat Psychiatry

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“…In addition, we found decreased connectivity between the left hippocampus and the right ITG in adolescent MDD. Previous studies focused on Sjogren's syndrome (65) and subcortical vascular mild cognitive impairment with depression symptoms (66) have revealed decreased connectivity between the hippocampus and ITG, which is related to cognitive impairment (such as visual memory) and depression symptoms. The interaction between the hippocampus and ITG contributes to visual memory and associative memory (67)(68)(69).…”

Section: Discussionmentioning

confidence: 99%

Family Conflict Associated With Intrinsic Hippocampal-OFC Connectivity in Adolescent Depressive Disorder

et al. 2022

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BackgroundFamily environment and life events have long been suggested to be associated with adolescent depression. The hippocampus plays a crucial role in the neural mechanism of major depressive disorder (MDD) through memory during stressful events. However, few studies have explored the exact neural mechanisms underlying these associations. Thus, the current study aimed to explore alterations in hippocampal functional connectivity (FC) in adolescent MDD based on resting-state functional magnetic resonance imaging and further investigate the relationship between hippocampal FC, environmental factors, and clinical symptom severity.MethodsHippocampal FC was calculated using the seed-based approach with the bilateral hippocampus as the seed for 111 adolescents with and without MDD; comparisons were made between participants with MDD and controls. We applied the Chinese version of the Family Environment Scale (FES-CV) and Adolescents Self-Rating Life Events Checklist (ASLEC) to evaluate family environment and life stress. Their relationship with hippocampal FC alterations was also investigated.ResultsWe found that compared to controls, adolescents with MDD showed decreased connectivity between the left hippocampus and bilateral orbital frontal cortex (OFC) and right inferior temporal gyrus. In addition, the hippocampal-OFC connectivity was negatively correlated with conflict scores of the FES-CV in the MDD group and mediated the association between family conflict and depressive and anxiety symptoms.ConclusionOur findings are novel in the field and demonstrate how family conflict contributes to MDD symptomatology through hippocampal-OFC connectivity; these findings may provide potential targets for personalized treatment strategies.

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“…All svMCI patients were enrolled from a previous randomized control study ( Zheng et al, 2022b ), whereas healthy participants were enrolled from community residents by advertisements. Complete recruitment details were described in our prior work ( Lyu et al, 2019 ; Wang J. et al, 2020 ; Xu J. et al, 2020 ; Xu Z. et al, 2020 ). Briefly, the diagnosis criteria of svMCI were performed according to Petersen’s criteria ( Petersen, 2004 ).…”

Section: Methodsmentioning

confidence: 99%

Lateralized brain activities in subcortical vascular mild cognitive impairment with differential Chinese medicine patterns: A resting-state functional magnetic resonance imaging study

et al. 2022

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BackgroundSubcortical vascular mild cognitive impairment (svMCI) is one of the most treatable cognitive impairments, but could be hampered by the high clinical heterogeneities. Further classification by Chinese Medicine (CM) patterns has been proved to stratify its clinical heterogeneities. It remains largely unknown of the spontaneous brain activities regarding deficiency patterns (DPs) and excess patterns (EPs) of svMCI patients based on fMRI data.ObjectiveWe aim to provide neuroimaging evidence of altered resting-state brain activities associated with DPs and EPs in svMCI patients.MethodsThirty-seven svMCI patients (PAs) and 23 healthy controls (CNs) were consecutively enrolled. All patients were categorized into either the EP group (n = 16) and the DP group (n = 21) based on a quantitative CM scale. The fractional amplitude of low-frequency fluctuation (fALFF) value was used to make comparisons between different subgroups.ResultsThe DP group showed significant differences of fALFF values in the right middle frontal gyrus and the right cerebellum, while the EP group showed significant differences in the left orbitofrontal gyrus and the left cerebellum, when compared with the CN group. When compared with the EP group, the DP group had markedly increased fALFF values in the left superior temporal gyrus, right middle temporal gyrus and brainstem. The decreased fALFF values was shown in the right anterior cingulate and paracingulate gyri. Among the extensive areas of frontotemporal lobe, the Montreal Cognitive Assessment (MoCA) scores were significantly correlated with the reduced fALFF value of the right middle frontal gyrus and the left orbitofrontal gyrus.ConclusionOur results indicated that the DPs and EPs presented the lateralization pattern in the bilateral frontal gyrus, which will probably benefit the future investigation of the pathogenesis of svMCI patients.

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Different patterns of functional and structural alterations of hippocampal sub-regions in subcortical vascular mild cognitive impairment with and without depression symptoms

Cited by 6 publications

References 68 publications

Abnormal functional connectivity of the habenula in mild cognitive impairment patients with depression symptoms revealed by resting‐state functional magnetic resonance imaging

Abnormal functional connectivity of the habenula in mild cognitive impairment patients with depression symptoms revealed by resting‐state functional magnetic resonance imaging

Family Conflict Associated With Intrinsic Hippocampal-OFC Connectivity in Adolescent Depressive Disorder

Lateralized brain activities in subcortical vascular mild cognitive impairment with differential Chinese medicine patterns: A resting-state functional magnetic resonance imaging study

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