Different patterns of excess all-cause mortality by age and sex in Hungary during the 2nd and 3rd waves of the COVID-19 pandemic

Fazekas-Pongor, Vince; Szarvas, Z; Nagy, Norbert D.; Péterfi, Anna; Ungvári, Zoltán; Horváth, Viktor J.; Mészáros, Szilvia; Tabák, Ádám G.

doi:10.1007/s11357-022-00622-3

Cited by 9 publications

(12 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Elderly with Coronavirus disease 2019 suffered more severe cases and complications therefore this population showed increased morbidity and mortality ( 124 – 126 ). A recent study examined the possible protective and biomarker role of PACAP and VIP during SARS‐CoV‐2 infection, but no significant differences were found between PACAP plasma levels and the groups analyzed, inflammatory markers, viral load ( 127 ).…”

Section: Critical Illnessmentioning

confidence: 99%

Role of endocrine PACAP in age-related diseases

et al. 2023

View full text Add to dashboard Cite

Pituitary adenylate cyclase activating polypeptide (PACAP) is a conserved neuropeptide, which confers diverse anti-aging endocrine and paracrine/autocrine effects, including anti-apoptotic, anti-inflammatory and antioxidant action. The results of the in vivo and in vitro experiments show that increasing emphasis is being placed on the diagnostic/prognostic biomarker potential of this neuropeptide in a wide array of age-related diseases. After the initial findings regarding the presence and alteration of PACAP in different body fluids in physiological processes, an increasing number of studies have focused on the changes of its levels in various pathological conditions associated with advanced aging. Until 2016 – when the results of previous human studies were reviewed – a vast majority of the studies had dealt with age-related neurological diseases, like cerebrovascular and neurodegenerative diseases, multiple sclerosis, as well as some other common diseases in elderly such as migraine, traumatic brain injury and post-traumatic stress disorder, chronic hepatitis and nephrotic syndrome. The aim of this review is to summarize the old and the new results and highlight those ‘classical’ and emerging clinical fields in which PACAP may become subject to further investigation as a diagnostic and/or prognostic biomarker in age-related diseases.

show abstract

Section: Critical Illnessmentioning

confidence: 99%

Role of endocrine PACAP in age-related diseases

et al. 2023

View full text Add to dashboard Cite

show abstract

“…The excess CMR was calculated by fitting a multiple linear regression model [18] assuming the combined effect of several independent risk factors described as potential confounders, such as the age and gender distributions in the population [3,9,11,12], which depends on the number of live births and net migration, and the proportion of older people:…”

Section: Risk Modelingmentioning

confidence: 99%

“…A number of studies since the onset of the pandemic [3][4][5][8][9][10][11][12][13][14][15] described the impact of the pandemic using specific mortality indicators, such as infection fatality rate (IFR) and case fatality rate (CFR). These widely used measures of infection prevalence are sensitive to certain demographic and socioeconomic conditions, which may vary from country to country.…”

Section: Introductionmentioning

confidence: 99%

“…According to the WHO, "... the true rate of transmission is often underestimated because a significant proportion of people with infection are not detected, either because they are asymptomatic or have only mild symptoms" [13]. Thus, the use of specific mortality rates may be compromised by underestimation [11]. On the other hand, the specific mortality rate for patients admitted to a hospital [14] would be higher than among the rest of the infected, and may lead to an overestimation of the consequences of SARS-CoV-2 infection when extrapolated to the entire population [15].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Assessment Of COVID-19 Pandemic-Related Detrimental Impact On The Population Of Nuclear City: Two-Year Results

Осипов¹,

Фомин

2023

Russ Open Med J

View full text Add to dashboard Cite

Background — Since the announcement of the global coronavirus infection disease (COVID-19) pandemic, the attempts to assess the pandemic-related detrimental impact are of particular interest. The methodology of assessing the overall mortality attributed to COVID-19 pandemic, unlike the use of specific indicators that are sensitive to different methods of accounting the number of infected and deaths, provides more clear understanding of the pandemic-related impact. Objective — Quantitative assessment of the pandemic-related detrimental impact caused by the novel coronavirus infection in a small nuclear city, which is relevant for evaluating the effectiveness of anti-epidemic measures. Methods and Results — The population changes in a small urban district located in the South Ural Region of the Russian Federation were retrospectively analyzed for the decade, based on the open-source demographic data. The pandemic-related detrimental impact was calculated as overall excess mortality rate, compared with the previous non-pandemic years by using the additive model of excess absolute risk. The number of absolute excess deaths, adjusted for gender, age, population size, and number of diseased, was modeled using multivariate linear regression. The pandemic-related detriment was calculated based on the number of predicted excess deaths attributed to COVID-19. The relationship between the total number of deaths and the number of COVID-19 cases was analyzed. The total predicted two-year excess of pandemic-related deaths was 557.9. The pandemic-related total excess mortality per 1,000 patients infected with SARS-Cov-2 was 50.2 (95% CI 38.4; 62.0). Conclusion — The analyses revealed significant impact of the COVID-19 pandemic on the overall excess mortality in the nuclear city population in 2020 and 2021 implemented in both direct and indirect way. The population size was a major significant risk factor confounding the overall mortality. In order to develop an effective strategy to control and prevent the consequences of a pandemic, further monitoring of the epidemic situation in a nuclear city is required.

show abstract

“…Slowing the spread of the global epidemic remains a paramount importance to everyone, with many segments of society working to reduce the number of new infections (2). The disease has mild to moderately severe symptoms in most infected individuals, where the recovery can happen without hospitalization (3). However, people with chronic diseases such as chronic obstructive pulmonary disease (COPD) and older people are at a higher risk of developing serious complications (4).…”

Section: Introductionmentioning

confidence: 99%

First booster dose uptake of COVID-19 vaccine and disease-related factors in chronic obstructive pulmonary disease—a cross-sectional survey in Hungary

Fekete¹,

Horváth²,

Santa³

et al. 2023

Ann Palliat Med

View full text Add to dashboard Cite

Background: In chronic obstructive pulmonary disease (COPD), uptake of the coronavirus disease 2019 (COVID-19) booster vaccine is important, as they are more likely to develop serious complications. Our aim was to investigate the uptake rate of first booster vaccination against COVID-19 among COPD patients and to identify other related factors of vaccine uptake. Methods: We conducted a multicenter survey of COPD patients in Hungary by region: eastern, western and central ones from 15 November 2021. Respiratory function test results, anthropometric data and vaccination status were recorded for 1510 randomly selected patients over 35 years of age. Multiple logistic regression analysis was used to determine factors associated with uptake of COVID-19 first booster dose vaccines.Results: The average age was 67 [61-72] years, for men it was: 67 [62-73] and 66 [60-72] years for women, with a sample of 47.95% men and 52.05% women. The uptake rate of the COVID-19 first booster vaccine during the study period was 62.45%. Comparing patients who received the 3rd vaccine with those who did not receive the 3rd vaccine, the difference was significant in quality of life: COPD Assessment Test (CAT):16 [11][12][13][14][15][16][17][18][19][20][21] vs. 14 [10-19], P<0.001, modified Medical Research Council (mMRC) dyspnea scale: 2 [2-2] vs. 2 [1-2], P=0.01 and in the number of moderate exacerbations: 1 [0-1] vs. 0 [0-1], P=0.04. In addition, who did not take the third vaccination significantly more people were hospitalized for acute severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (16 vs. 0, P<0.001) and almost the same proportion (n=14) required pulmonary outpatient rehabilitation for post-COVID symptoms. The factors that were most associated with higher COVID-19 vaccine first booster dose uptake were older age [odds ratio (OR): 1.06; 95% confidence interval (CI): 1.04-1.08], male gender (OR: 0.74; 95% CI: 0.57-0.96), absence of previous COVID-19 infection (OR: 0.34; 95% CI: 0.23-0.51). Conclusions:The uptake rate of the COVID-19 booster vaccine among COPD patients in Hungary is lower than the target, and is associated with disease-related factors, and age, sex, previous COVID infection.The global COVID-19 vaccination target is 70% and 100% for elderly, vulnerable patients. Highlighting the importance of taking booster vaccine(s) should be a priority for health workers.

show abstract

Different patterns of excess all-cause mortality by age and sex in Hungary during the 2nd and 3rd waves of the COVID-19 pandemic

Cited by 9 publications

References 32 publications

Role of endocrine PACAP in age-related diseases

Role of endocrine PACAP in age-related diseases

Assessment Of COVID-19 Pandemic-Related Detrimental Impact On The Population Of Nuclear City: Two-Year Results

First booster dose uptake of COVID-19 vaccine and disease-related factors in chronic obstructive pulmonary disease—a cross-sectional survey in Hungary

Contact Info

Product

Resources

About