Different Parts of the Chicken Embryo Egg Improve D-Galactose-Induced Aging in a Mice Model

Abstract

Chick (CE) or duck embryo eggs are known for nutritional supplement foods in traditional East countries for physical fitness enhancement and postpartum conditioning for many years. In this study, we evaluated the effects of different parts of the 10-day CE (embryo: CEr, yolk: CEw, and chorioallantoic membrane: CEp) on the antifatigue and antiaging activities in a D-galactose- (D-gal) induced aging mice model. The results showed CEp obviously increased the muscle weight and the liver and muscle glycogen content and enhanced exercise performance. In the antiaging assay, CEp significantly increased the activity of superoxide dismutase (SOD) and Glutathione Peroxidase (GPx). Moreover, the immunohistochemistry results of NRF-2 and HO-1 were also detected in the livers of mice in the D-gal/CEp group. The only partially potential such as CEr might improve OFT function with TG level, and CEw had strange grip strength. Therefore, we suggest that CEp has a potent antifatigue ability and could minimize the occurrence of age-associated disorders, more than other parts of the 10 days chicken embryo egg.

Long-Term Social Isolation-Induced Autophagy Inhibition and Cell Senescence Aggravate Cognitive Impairment in D(+)Galactose-Treated Male Mice

“…Linking the effect of aging and social isolation to cognitive decline has become very critical in developing therapies that can attenuate both phenomena that are common at a point in one’s development. Using the much-accepted model for aging in mice, this study employed the administration of D(+)Galactose to induce aging in mice ( Shwe et al, 2020 ; Hong et al, 2021 ) and assessed the effect of both aging and social isolation on cognition. Autophagy, a process utilized by cells to maintain homeostasis is very critical in cognitive performance ( Dikic and Elazar, 2018 ).…”

The Functions of Chicken Embryo Extract

“…The efficacy of different sections of the chicken embryo against aging induction was tested using a D-galinduced aging mice model. The chicken embryo possesses significant antifatigue properties, which may help to reduce the emergence of age-related disorders [37].…”