Different neural mechanisms underlie dizocilpine maleate- and dopamine agonist-induced locomotor activity

Mele, Andrea; Thomas, D.N.; Pert, Agu

doi:10.1016/s0306-4522(97)00277-7

Cited by 59 publications

(35 citation statements)

References 58 publications

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“…30) In a variety of experimental models of PD, many NMDA receptor blockers have shown anticataleptic activity, including dizocilpine, phencyclidine, memantine. [31][32][33][34] In the present study, administration of amantadine, a DA releaser and a non-selective NMDA receptor antagonist, also alleviated catalepsy in LCa/Mg mice. This ameliorating effect might be due not only to amantadine's induction of DA release but also to its NMDA receptor antagonist properties.…”

Section: Discussionsupporting

confidence: 63%

Combined Low Calcium and Lack Magnesium Is a Risk Factor for Motor Deficit in Mice

Taniguchi

Nakagawasai

Tan-No

et al. 2013

Bioscience, Biotechnology, and Biochemistry

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The populations of the Kii Peninsula in Japan and of Guam present high incidences of amyotrophic lateral sclerosis and Parkinsonism-dementia complex. It is thought that low levels of calcium (Ca) and magnesium (Mg) in the drinking water are involved in the pathogenesis of these diseases. The present study aimed to test the hypothesis that catalepsy, behavioral immobility and a Parkinsonian symptom results from functionally impaired dopaminergic neurons in mice fed low amounts of Ca and Mg (LCa/Mg). A group of mice fed a LCa/Mg diet for 6 weeks was compared to a control group on a standard diet. Cataleptic symptoms such as akinesia and rigidity were measured by the bar test. The anti-parkinsonian drugs dopamine (DA) precursor L-3,4-dihydroxy phenylamine (L-DOPA), the selective DA receptor D 2 agonist bromocriptine, and the DA releaser amantadine were tested for their effects on induced catalepsy. The mice developed catalepsy after 3 weeks on the LCa/Mg diet. LCa/Mg dietinduced catalepsy was improved by the administration of L-DOPA (50-200 mg/kg i.p.) in combination with benserazide (25 mg/kg i.p.), or of bromocriptine (0.25-4 mg/kg i.p.) or of amantadine (5-20 mg/kg i.p.). Immunohistochemical staining revealed that the intensity of tyrosine hydroxylase fluorescence was significantly decreased in the substantia nigra at the 6th week of LCa/Mg feeding in comparison with pair-fed controls. These results suggest that catalepsy in LCa/Mg mice results from hypofunction of the dopaminergic neurons. Moreover, our results support the hypothesis that LCa/Mg intake is one etiological factor in neurodegenerative disorders, including Parkinson's disease.

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Section: Discussionsupporting

confidence: 63%

Combined Low Calcium and Lack Magnesium Is a Risk Factor for Motor Deficit in Mice

Taniguchi

Nakagawasai

Tan-No

et al. 2013

Bioscience, Biotechnology, and Biochemistry

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“…However, downstream from the NAcc, the circuits activated by D-amphetamine and dizocilpine seem to diverge. Whereas the behavioral effects of D-amphetamine and other DA receptor agonists are mediated by reduction in the inhibitory tone of the NAcc-VP projections and an increase in VP functional output (Swerdlow et al, 1990), the behavioral actions of dizocilpine are independent of the VP and less well understood (Kretschmer and Koch, 1998;Mele et al, 1998;Kretschmer, 2000).…”

Section: Discussionmentioning

confidence: 99%

Virally Mediated Increased Neurotensin 1 Receptor in the Nucleus Accumbens Decreases Behavioral Effects of Mesolimbic System Activation

Cáceda¹,

Kinkead²,

Owens³

et al. 2005

J. Neurosci.

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“…Systemic and focal administration of DA agonists in terminal areas, such as nucleus accumbens and striatum, enhances locomotor activity in laboratory animals, and these effects are blocked by selective lesion of these areas (Kelly et al 1975;Staton and Solomon 1984;Mele et al 1998). More recently, these areas have been related to cognitive functions, such as learning and memory (Taghzouti et al 1985;Annett et al 1989;Ploeger et al 1994;Floresco et al 1996Floresco et al , 1997Setlow 1997;Adriani et al 1998;Setlow and McGaugh 1998;Usiello et al 1998;Sargolini et al 1999).…”

Section: Introductionmentioning

confidence: 99%

Role of dopaminergic system in reactivity to spatial and non-spatial changes in mice

et al. 2000

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Different neural mechanisms underlie dizocilpine maleate- and dopamine agonist-induced locomotor activity

Cited by 59 publications

References 58 publications

Combined Low Calcium and Lack Magnesium Is a Risk Factor for Motor Deficit in Mice

Combined Low Calcium and Lack Magnesium Is a Risk Factor for Motor Deficit in Mice

Virally Mediated Increased Neurotensin 1 Receptor in the Nucleus Accumbens Decreases Behavioral Effects of Mesolimbic System Activation

Role of dopaminergic system in reactivity to spatial and non-spatial changes in mice

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