Different modulation of oscillatory common neural drives to ankle muscles during abrupt and gradual gait adaptations

Kitatani, Ryosuke; Maeda, Akinori; Umehara, Jun; Yamada, Shigehito

doi:10.1007/s00221-021-06294-3

Cited by 7 publications

(5 citation statements)

References 69 publications

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“…However, we did not observe consistent beta-gamma coherence differences between pre-slow and post-slow that would be explained by fatigue. Alternatively, reduced modulation in beta-gamma coherence during split-belt adaptation may reflect less cortical involvement, due to greater reliance on implicit processes ( Kitatani et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

“…Electromyography coherence analysis has demonstrated a common neural drive at 15–45 Hz to the tibialis anterior that is modulated during walking adaptation ( Sato and Choi, 2019 ; Oshima et al, 2021 ; Kitatani et al, 2022 ). During normal walking, a significant amount of coherence can be found between EMG recorded from the proximal and distal ends of the tibialis anterior in the alpha (8–15 Hz), beta (15–30 Hz), and gamma (30–45 Hz) frequencies during the swing phase of gait.…”

Section: Introductionmentioning

confidence: 99%

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Corticospinal drive is associated with temporal walking adaptation in both healthy young and older adults

Sato

Choi

2022

Front. Aging Neurosci.

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Healthy aging is associated with reduced corticospinal drive to leg muscles during walking. Older adults also exhibit slower or reduced gait adaptation compared to young adults. The objective of this study was to determine age-related changes in the contribution of corticospinal drive to ankle muscles during walking adaptation. Electromyography (EMG) from the tibialis anterior (TA), soleus (SOL), medial, and lateral gastrocnemius (MGAS, LGAS) were recorded from 20 healthy young adults and 19 healthy older adults while they adapted walking on a split-belt treadmill. We quantified EMG-EMG coherence in the beta-gamma (15–45 Hz) and alpha-band (8–15 Hz) frequencies. Young adults demonstrated higher coherence in both the beta-gamma band coherence and alpha band coherence, although effect sizes were greater in the beta-gamma frequency. The results showed that slow leg TA-TA coherence in the beta-gamma band was the strongest predictor of early adaptation in double support time. In contrast, early adaptation in step length symmetry was predicted by age group alone. These findings suggest an important role of corticospinal drive in adapting interlimb timing during walking in both young and older adults.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Corticospinal drive is associated with temporal walking adaptation in both healthy young and older adults

Sato

Choi

2022

Front. Aging Neurosci.

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“…A future EEG study that uses a single-leg adaptation paradigm (e.g. introducing a force via a cable that pulls only one leg; (Blanchette & Bouyer, 2009;Kitatani et al, 2022)) might differentiate tonic changes versus gait-related changes in the posterior parietal cortex.…”

Section: Discussionmentioning

confidence: 99%

Exploring Electrocortical Signatures of Gait Adaptation: Differential Neural Dynamics in Slow and Fast Gait Adapters

Jacobsen,

Ferris

2024

eNeuro

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Individuals exhibit significant variability in their ability to adapt locomotor skills, with some adapting quickly and others more slowly. Differences in brain activity likely contribute to this variability, but direct neural evidence is lacking. We investigated individual differences in electrocortical activity that led to faster locomotor adaptation rates. We recorded high-density electroencephalography while young, neurotypical adults adapted their walking on a split-belt treadmill and grouped them based on how quickly they restored their gait symmetry. Results revealed unique spectral signatures within the posterior parietal, bilateral sensorimotor, and right visual cortices that differ between fast and slow adapters. Specifically, fast adapters exhibited lower alpha power in the posterior parietal and right visual cortices during early adaptation, associated with quicker attainment of steady-state step length symmetry. Decreased posterior parietal alpha may reflect enhanced spatial attention, sensory integration, and movement planning to facilitate faster locomotor adaptation. Conversely, slow adapters displayed greater alpha and beta power in the right visual cortex during late adaptation, suggesting potential differences in visuospatial processing. Additionally, fast adapters demonstrated reduced spectral power in the bilateral sensorimotor cortices compared to slow adapters, particularly in the theta band, which may suggest variations in perception of the split-belt perturbation. These findings suggest that alpha and beta oscillations in the posterior parietal and visual cortices and theta oscillations in the sensorimotor cortex are related to the rate of gait adaptation.Significance StatementThe specific neural dynamics and factors influencing variability in individual locomotor adaptation rates remain active areas of exploration. We provide a novel characterization of cortical dynamics associated with gait adaptability in young, neurotypical adults. We identified distinct electrocortical patterns in the posterior parietal, sensorimotor, and visual cortices that differ between those who adapt to a split-belt treadmill quickly versus slowly. Notably, our findings suggest that posterior parietal alpha plays a crucial role in enhancing locomotor adaptation, potentially by regulating multisensory integration and visuo-spatial attention.

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“…Impaired cortical engagement may be particularly detrimental during abrupt and challenging balance perturbations that elicit greater corticomotor drive to for balance recovery compared to less abrupt balance perturbations, as evidenced in neurotypical individuals by increases in functional connectivity between cortical activity and reactive lower limb motor responses with more challenging perturbations. 48 Together, these findings suggest that the speed and effectiveness of sensorimotor error detection and information processing is compromised in individuals with cortical and subcortical lesions .…”

Section: Impaired Cortical Engagement May Contribute To Mobility Defi...mentioning

confidence: 95%

Delayed cortical engagement associated with balance dysfunction after stroke

Palmer,

Payne,

Mirdamadi

et al. 2023

Preprint

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Cortical resources are typically engaged for balance and mobility in older adults, but these resources are impaired post-stroke. Although slowed balance and mobility after stroke have been well-characterized, the effects of unilateral cortical lesions due to stroke on neuromechanical control of balance is poorly understood. Our central hypothesis is that stroke impairs the ability to rapidly and effectively engage the cerebral cortex during balance and mobility behaviors, resulting in asymmetrical contributions of each limb to balance control. Using electroencephalography (EEG), we assessed cortical N1 responses evoked over fronto-midline regions (Cz) during balance recovery in response to backward support-surface perturbations loading both legs, as well as posterior-lateral directions that preferentially load the paretic or nonparetic leg. Cortical N1 responses were smaller and delayed in the stroke group. While older adults exhibited weak or absent relationships between cortical responses and clinical function, stroke survivors exhibited strong associations between slower N1 latencies and slower walking, lower clinical mobility, and lower balance function. We further assessed kinetics of balance recovery during perturbations using center of pressure rate of rise. During backward support-surface perturbations that loaded the legs bilaterally, balance recovery kinetics were not different between stroke and control groups and were not associated with cortical response latency. However, lateralized perturbations revealed slower kinetic reactions during paretic loading compared to controls, and to non-paretic loading within stroke participants. Individuals post stroke had similar nonparetic-loaded kinetic reactions to controls implicating that they effectively compensate for impaired paretic leg kinetics when relying on the non-paretic leg. In contrast, paretic-loaded balance recovery revealed time-synchronized associations between slower cortical responses and slower kinetic reactions only in the stroke group, potentially reflecting the limits of cortical engagement for balance recovery revealed within the behavioral context of paretic motor capacity. Overall, our results implicate individuals after stroke may be uniquely limited in their balance ability by the slowed speed of their cortical engagement, particularly under challenging balance conditions that rely on the paretic leg. We expect this neuromechanical insight will enable progress toward an individualized framework for the assessment and treatment of balance impairments based on the interaction between neuropathology and behavioral context.

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Different modulation of oscillatory common neural drives to ankle muscles during abrupt and gradual gait adaptations

Cited by 7 publications

References 69 publications

Corticospinal drive is associated with temporal walking adaptation in both healthy young and older adults

Corticospinal drive is associated with temporal walking adaptation in both healthy young and older adults

Exploring Electrocortical Signatures of Gait Adaptation: Differential Neural Dynamics in Slow and Fast Gait Adapters

Delayed cortical engagement associated with balance dysfunction after stroke

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