Different methods of hydroxyapatite‐based coatings on external fixator pin with high adhesion approach

Nakhaei, Mehrnoush; Jirofti, Nafiseh; Ebrahimzadeh, Mohammad Hosein; Moradi, Ali

doi:10.1002/ppap.202200219

Cited by 9 publications

(13 citation statements)

References 224 publications

(337 reference statements)

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“…Even cataloguing them with a brief description of their physical and chemical principles coupled with the key process parameters appears to be rather long. Second, although all techniques have been developed and/or adapted solely to deposit CaPO 4 , the differences in physical and chemical principles commonly provide deposits, whose properties are difficult to compare (Figure 32) [883]. More to the point, application or non-application of various pre-and post-deposition treatments, as well as application of additional processing techniques such as a magnetic field [162,163], UV light [164] or ultrasonics [139,165,166] during deposition complicates the comparison even more.…”

Section: A Brief Description Of the Most Important Propertiesmentioning

confidence: 99%

“…Therefore, let me limit myself just by brief descriptions of the most important properties of CaPO 4 deposits and their biomedical applications. Reproduced with permission from [883].…”

Section: A Brief Description Of the Most Important Propertiesmentioning

confidence: 99%

“…Comparison of CaPO 4 deposits prepared by different methods. Abbreviations: CVDchemical vapor deposition; EHD-electrohydrodynamic coating; EPD-electrophoretic deposition; IBAD-ion beam assisted deposition; MAO-micro-arc oxidation; PVDMS-physical vapor deposition magnetron sputtering; PLD-pulsed laser deposition; SIM-surface-induced mineralization.Reproduced with permission from[883].…”

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confidence: 99%

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There Are over 60 Ways to Produce Biocompatible Calcium Orthophosphate (CaPO4) Deposits on Various Substrates

Dorozhkin

2023

J. Compos. Sci.

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A The present overview describes various production techniques for biocompatible calcium orthophosphate (abbreviated as CaPO4) deposits (coatings, films and layers) on the surfaces of various types of substrates to impart the biocompatible properties for artificial bone grafts. Since, after being implanted, the grafts always interact with the surrounding biological tissues at the interfaces, their surface properties are considered critical to clinical success. Due to the limited number of materials that can be tolerated in vivo, a new specialty of surface engineering has been developed to desirably modify any unacceptable material surface characteristics while maintaining the useful bulk performance. In 1975, the development of this approach led to the emergence of a special class of artificial bone grafts, in which various mechanically stable (and thus suitable for load-bearing applications) implantable biomaterials and artificial devices were coated with CaPO4. Since then, more than 7500 papers have been published on this subject and more than 500 new publications are added annually. In this review, a comprehensive analysis of the available literature has been performed with the main goal of finding as many deposition techniques as possible and more than 60 methods (double that if all known modifications are counted) for producing CaPO4 deposits on various substrates have been systematically described. Thus, besides the introduction, general knowledge and terminology, this review consists of two unequal parts. The first (bigger) part is a comprehensive summary of the known CaPO4 deposition techniques both currently used and discontinued/underdeveloped ones with brief descriptions of their major physical and chemical principles coupled with the key process parameters (when possible) to inform readers of their existence and remind them of the unused ones. The second (smaller) part includes fleeting essays on the most important properties and current biomedical applications of the CaPO4 deposits with an indication of possible future developments.

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Section: A Brief Description Of the Most Important Propertiesmentioning

confidence: 99%

“…Therefore, let me limit myself just by brief descriptions of the most important properties of CaPO 4 deposits and their biomedical applications. Reproduced with permission from [883].…”

Section: A Brief Description Of the Most Important Propertiesmentioning

confidence: 99%

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confidence: 99%

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There Are over 60 Ways to Produce Biocompatible Calcium Orthophosphate (CaPO4) Deposits on Various Substrates

Dorozhkin

2023

J. Compos. Sci.

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“…External fixation is a versatile and minimally invasive method for treating various bone diseases, mainly fractures, non-unions, and arthrodesis of joints [1,2]. The fixator pins (also called Schanz Pins) are drilled into the affected bone of the patient via the skin [3][4][5][6]. They cross the human skin barrier during treatment lasting from a few days to several months [1,2].…”

Section: Introductionmentioning

confidence: 99%

“…Since this system is outside the human body, the Schanz Pins break through the skin barrier, which defines these as 2 of 21 percutaneous implants. Because these titanium alloy or stainless steel pins are polished to achieve good cleanability, the skin cells do not adhere [2][3][4][5][6]. In the end, pathogen entry points remain at the skin level during treatment [1,3,7].…”

Section: Introductionmentioning

confidence: 99%

The Impact of Ultrashort Pulse Laser Structuring of Metals on In-Vitro Cell Adhesion of Keratinocytes

Staehlke,

Barth,

Muench

et al. 2024

JFB

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Besides the need for biomaterial surface modification to improve cellular attachment, laser-structuring is favorable for designing a new surface topography for external bone fixator pins or implants. The principle of this study was to observe how bioinspired (deer antler) laser-induced nano–microstructures influenced the adhesion and growth of skin cells. The goal was to create pins that allow the skin to attach to the biomaterial surface in a bacteria-proof manner. Therefore, typical fixator metals, steel, and titanium alloy were structured using ultrashort laser pulses, which resulted in periodical nano- and microstructures. Surface characteristics were investigated using a laser scanning microscope and static water contact angle measurements. In vitro studies with human HaCaT keratinocytes focused on cell adhesion, morphology, actin formation, and growth within 7 days. The study showed that surface functionalization influenced cell attachment, spreading, and proliferation. Micro-dimple clusters on polished bulk metals (DC20) will not hinder viability. Still, they will not promote the initial adhesion and spreading of HaCaTs. In contrast, additional nanostructuring with laser-induced periodic surface structures (LIPSS) promotes cell behavior. DC20 + LIPSS induced enhanced cell attachment with well-spread cell morphology. Thus, the bioinspired structures exhibited a benefit in initial cell adhesion. Laser surface functionalization opens up new possibilities for structuring, and is relevant to developing bioactive implants in regenerative medicine.

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Complete characterization of sol–gel silver-fluoride-hydroxyapatite coatings on external fixators for orthopedic surgery applications: structural, biological, and in vitro evaluations

Jirofti,

Ebrahimzadeh,

Moradi

2023

J Sol-Gel Sci Technol

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Different methods of hydroxyapatite‐based coatings on external fixator pin with high adhesion approach

Cited by 9 publications

References 224 publications

There Are over 60 Ways to Produce Biocompatible Calcium Orthophosphate (CaPO4) Deposits on Various Substrates

There Are over 60 Ways to Produce Biocompatible Calcium Orthophosphate (CaPO4) Deposits on Various Substrates

The Impact of Ultrashort Pulse Laser Structuring of Metals on In-Vitro Cell Adhesion of Keratinocytes

Complete characterization of sol–gel silver-fluoride-hydroxyapatite coatings on external fixators for orthopedic surgery applications: structural, biological, and in vitro evaluations

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