Different metabolic patterns analysis of Parkinsonism on the 18F-FDG PET

Juh, R; Kim, Jae-Sung; Moon, Dae-Hyuk; Choe, Bo-Young; Suh, Tasuk

doi:10.1016/s0720-048x(03)00214-6

Cited by 118 publications

(97 citation statements)

References 25 publications

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“…On early phase images, a decrease or increase of regional uptake is shown in MSA-P, MSA-C, PSP, and DLB groups compared with the IPD group. These findings generally correspond with several previous studies that have identified characteristic DAT binding of neurodegenerative parkinsonism [32][33][34] and glucose metabolism patterns with IPD, MSA, PSP, and DLB [11,23,26,27], respectively. NA not applicable…”

Section: Discussionsupporting

confidence: 92%

“…The regional uptake pattern observed in the MSA-P group with decreased uptake in striatum and cerebellum and increased uptake in occipital cortex compared with the IPD group corresponds to earlier findings of glucose metabolism [11,37]. However, in our and other studies using perfusion ligands, significant differences could not be demonstrated in MSA-P and IPD patients in the pons [38], a finding that is at odds with hypometabolism found in FDG PET studies.…”

Section: Discussionsupporting

confidence: 82%

“…They classified these images as normal, MSA-P, MSA-C, PSP, or DLB, based on previous criteria of their glucose metabolism or brain perfusion, decreased regional uptake of the putamen, pons and cerebellum in MSA-P, decreased regional uptake of the cerebellum in MSA-C, decreased regional uptake of the caudate nucleus, the thalamus, midbrain and the cingulate gyrus in PSP, and decreased regional uptake of the occipital area, posterior cingulate cortex and temporo-parietal association area in DLB [11,22,[26][27][28]. The interobserver agreement and rate of correct classification were measured.…”

Section: Early Phase Imaging Analysesmentioning

confidence: 99%

“…Various methods have been employed to improve the accuracy of differential diagnosis in patients with parkinsonism-for example, F-18 FDG positron emission tomography (PET) [11], dual-radionuclide brain single photon emission computed tomography (SPECT) [12], and diffusion-weighted magnetic resonance imaging (MRI) [13]. Particularly, F-18 FDG PET is helpful in showing preserved or raised glucose metabolism of lentiform nucleus in IPD, while showing it is reduced in most APD [14].…”

Section: Introductionmentioning

confidence: 99%

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Differential Diagnosis of Parkinsonism Using Dual-Phase F-18 FP-CIT PET Imaging

et al. 2012

Nucl Med Mol Imaging

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Purpose Dopamine transporter (DAT) imaging can demonstrate presynaptic dopaminergic neuronal loss in Parkinson's disease (PD). However, differentiating atypical parkinsonism (APD) from PD is often difficult. We investigated the usefulness of dual-phase F-18 FP-CIT positron emission tomography (PET) imaging in the differential diagnosis of parkinsonism. Methods Ninety-eight subjects [five normal, seven druginduced parkinsonism (DIP), five essential tremor (ET), 24 PD, 20 multiple system atrophy-parkinson type (MSA-P), 13 multiple system atrophy-cerebellar type (MSA-C), 13 progressive supranuclear palsy (PSP), and 11 dementia with Lewy bodies (DLB)] underwent F-18 FP-CIT PET. PET images were acquired at 5 min (early phase) and 3 h (late phase) after F-18 FP-CIT administration (185 MBq). Regional uptake pattern of cerebral and cerebellar hemispheres was assessed on early phase images and striatal DAT binding pattern was assessed on late phase images, using visual, quantitative, and statistical parametric mapping (SPM) analyses. Results Striatal DAT binding was normal in normal, ET, DIP, and MSA-C groups, but abnormal in PD, MSA-P, PSP, and DLB groups. No difference was found in regional uptake on early phase images among normal DAT binding groups, except in the MSA-C group. Abnormal DAT binding groups showed different regional uptake pattern on early phase images compared with PD in SPM analysis (FDR< 0.05). When discriminating APD from PD, visual interpretation of the early phase image showed high diagnostic sensitivity and specificity (75.4 % and 100 %, respectively). Regarding the ability to distinguish specific APD, sensitivities were 81 % for MSA-P, 77 % for MSA-C, 23 % for PSP, and 54.5 % for DLB. Conclusions Dual-phase F-18 FP-CIT PET imaging is useful in demonstrating striatal DAT loss in neurodegenerative parkinsonism, and also in differentiating APD, particularly MSA, from PD.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 82%

Section: Early Phase Imaging Analysesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Differential Diagnosis of Parkinsonism Using Dual-Phase F-18 FP-CIT PET Imaging

et al. 2012

Nucl Med Mol Imaging

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“…Beyin FDG PET görüntüleme bulgularına dayanan tanısal sınıflandırma kesin klinik tanı ile %90 oranında örtüşmekte ve nörodejeneratif parkinsonizm nedenleri (PH, MSA, PSP ve LCD) %90 oranında ayırt edilebilmektedir (21,22,35,40). Parkinsonizm sendromlarında beyin FDG PET görüntüleme saptanan anormal bulguların yaygınlığı ve derecesi klinik bulgular ile genellikle korelasyon gösterir (1,3,19,23,24,30,34,35,39,49,50,51,52). PH için klinik belirtiler ile ilişkili özgül metabolik tutulum biçimleri bulunur: Örneğin; tremor ile ilişkili serebellotalamo-kortikal yolakların etkilendiği (23,31,53); motor belirtiler ile ilişkili olarak putamen ve premotor korteksi içine alan (19,50,52,53); bilişsel bozukluklar ile ilişkili olarak da frontal ve parietal asosiyasyon alanlarında hipometabolizma ve serebellumda hipermetabolizma ile karakterize özgül metabolik ağ yapıları tanımlanmıştır (53,54).…”

Section: Beyin Fluorodeoksiglukoz Pozitron Emisyon Tomografisibulgularıunclassified

Nuclear Medicine Applications in Movement Disorders

Akdemir¹,

Atay²

2017

Nts

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Öz Abstract GirişNükleer tıp görüntülemenin ilgi alanında beyindeki nörodejeneratif patolojik süreçlere bağlı olarak gelişen hipokinetik hareket bozukluğu hastalıkları yer alır. Parkinson hastalığının (PH) hipokinetik hareket bozukluğunun en sık görülen nedeni olması ve bu grupta bulunan diğer hastalıkların PH ile benzer klinik bulgular göstermesi nedeniyle bu hastalıklarda ortaya çıkan klinik tablo parkinsonizm olarak adlandırılır. Parkinsonizmde temel klinik bulgular tremor, rijidite, bradikinezi ve postürel dengesizliktir. Bu bulgular PH dışında Parkinson artı (Parkinson plus) sendromları olarak adlandırılan multi-sistem atrofi (MSA), progresif supra-nükleer palsi (PSP), kortikobazal dejenerasyon (KBD) ve Lewy-cisimcikli demansta da (LCD) görülür (1). Özellikle hastalığın erken döneminde nörodejeneratif özellikteki bu Parkinson artı sendromları klinik olarak PH ile karışabilir (2). Bunların dışında dopaminerjik nöron kaybına neden olmayan esansiyel tremor (ET) ve diğer sekonder parkinsonizm nedenlerinin (ilaç kullanımına, serebrovasküler olaya, travmaya veya enfeksiyona Ya zış maAd re si/Ad dressforCor res pon den ce

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