Different mean thickness implicates involvement of the cortex in migraine

Yu, Zhaojie; Peng, Jing; Lv, Yan-bing; Zhao, Mingfei; Xie, Bing; Liang, Minglong; Li, Haitao; Zhou, Zhenhua

doi:10.1097/md.0000000000004824

Cited by 17 publications

(9 citation statements)

References 33 publications

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“…Additionally, several other regions with decreased GMV were observed, including the inferior parietal lobule and supramarginal gyrus. Alterations in the GMV of the inferior parietal lobule have been reported in many previous cerebral structural studies on migraine (Yu et al, ). Those studies showed that the cortical thickness of the inferior parietal lobe in the migraine patient group was significantly decreased compared with that in the healthy control group.…”

Section: Discussionsupporting

confidence: 59%

Altered structure of the vestibular cortex in patients with vestibular migraine

Zhe¹,

Gao²,

Chen

et al. 2020

Brain and Behavior

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Introduction Previous voxel‐based morphometry (VBM) studies have revealed changes in brain structure in patients with vestibular migraine (VM); these findings have improved the present understanding of pathophysiology. Few other studies have assessed the association between structural changes and the severity of dizziness in VM. This study aimed to examine the structural changes and cortical morphometric features associated with migraine and vertigo attacks in patients with VM. Methods Twenty patients with VM and 20 healthy normal volunteers were scanned on a 3‐tesla MRI scanner. The gray matter volume (GMV) was estimated using the automated Computational Anatomy Toolbox (CAT12). The relationship between clinical parameters and morphometric abnormalities was also analyzed in VM. Results Compared with controls, VM patients have decreased GMV in the prefrontal cortex (PFC), posterior insula–operculum regions, inferior parietal gyrus, and supramarginal gyrus. Moreover, patient scores on the Dizziness Handicap Inventory (DHI) score showed a negative correlation with GMV in the posterior insula–operculum regions. Conclusion These findings demonstrated abnormality in the central vestibular cortex and correlations between dizziness severity and GMV in core regions of the vestibular cortex of VM patients, suggesting a pathophysiological role of these core vestibular regions in VM patients.

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Section: Discussionsupporting

confidence: 59%

Altered structure of the vestibular cortex in patients with vestibular migraine

Zhe¹,

Gao²,

Chen

et al. 2020

Brain and Behavior

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“…The angular gyrus is a part of the inferior parietal lobule and is located in the posterior part of this lobule and the junction of the occipital, temporal, and parietal lobes. It is mainly involved in the response to pain and the sensation of temperature and pressure (36,37). It is also an important region in the default mode network (DMN), which participates in the brain's cognitive, emotional, behavioral and other advanced functions in the resting state (38).…”

Section: Discussionmentioning

confidence: 99%

Differential Modulating Effect of Acupuncture in Patients With Migraine Without Aura: A Resting Functional Magnetic Resonance Study

et al. 2021

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Introduction: Migraine is a recurrent neurological disorder, the symptoms of which can be significantly relieved by acupuncture. However, the central mechanism via which acupuncture exerts its therapeutic effect in migraine is unclear. The aim of this study was to compare the differences in regional homogeneity (ReHo) between patients with migraine without aura (MwoA) and healthy controls (HCs) and to explore the immediate and cumulative therapeutic effect of acupuncture in patients with MwoA using resting-state functional magnetic resonance imaging (fMRI).Methods: The study subjects were 40 patients with MwoA and 16 matched HCs. The patients with MwoA received acupuncture on 2 days per week for 6 weeks for a total of 12 sessions followed by 24 weeks of follow-up. The primary clinical efficacy outcomes were the number of days with migraine and the average severity of headache. Secondary outcomes were the Migraine-Specific Quality of Life Questionnaire, Self-Rating Anxiety Scale, and Self-Rating Depression Scale scores. In the migraine group, resting-state blood-oxygen-level-dependent fMRI scans were obtained at baseline and after the first and 12th acupuncture sessions to measure the ReHo value. In the HCs, only a baseline resting-state blood-oxygen-level-dependent fMRI scan was obtained.Results: Compared with the control group, the migraine group had a significantly lower ReHo value in the cerebellum, which increased after the first acupuncture session. Long-term acupuncture significantly improved migraine symptoms and mood with a therapeutic effect that lasted for at least 6 months. After 12 acupuncture sessions, there were significant increase of cerebellum and angular gyrus in the migraine group.Conclusion: These findings suggest that migraine is related to cerebellar dysfunction. Acupuncture can relieve the symptoms of migraine, improve dysfunction of cerebellum, and activate brain regions involved in modulation of pain and emotion The cumulative therapeutic effect of acupuncture is more extensive and significant than its immediate effect.

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“…Moreover, the calcarine sulcus is responsible for multisensory processing in affective, sensory and cognitive aspects of pain [3, 30]. Furthermore, abnormal FC of the calcarine has been shown to be involved in many independent networks, corresponding to the perspective that the experience of pain is complex and involves multidimensional processing [31]. Thus, the lower activity of the left calcarine sulcus in MwoA patients could be related to the lower tolerance threshold to the normally noxious or non-noxious sensory stimuli.…”

Section: Discussionmentioning

confidence: 99%

Impaired intrinsic functional connectivity between the thalamus and visual cortex in migraine without aura

et al. 2019

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Background: Resting-state functional magnetic resonance imaging (fMRI) has confirmed disrupted visual network connectivity in migraine without aura (MwoA). The thalamus plays a pivotal role in a number of pain conditions, including migraine. However, the significance of altered thalamo-visual functional connectivity (FC) in migraine remains unknown. The goal of this study was to explore thalamo-visual FC integrity in patients with MwoA and investigate its clinical significance. Methods: Resting-state fMRI data were acquired from 33 patients with MwoA and 22 well-matched healthy controls. After identifying the visual network by independent component analysis, we compared neural activation in the visual network and thalamo-visual FC and assessed whether these changes were linked to clinical characteristics. We used voxel-based morphometry to determine whether functional differences were dependent on structural differences. Results: The visual network exhibited significant differences in regions (bilateral cunei, right lingual gyrus and left calcarine sulcus) by inter-group comparison. The patients with MwoA showed significantly increased FC between the left thalami and bilateral cunei and between the right thalamus and the contralateral calcarine sulcus and right cuneus. Furthermore, the neural activation of the left calcarine sulcus was positively correlated with visual analogue scale scores (r = 0.319, p = 0.043), and enhanced FC between the left thalamus and right cuneus in migraine patients was negatively correlated with Generalized Anxiety Disorder scores (r = − 0.617, p = 0.005). Conclusion: Our data suggest that migraine distress is exacerbated by aberrant feedback projections to the visual network, playing a crucial role in migraine physiological mechanisms. The current study provides further insights into the complex scenario of migraine mechanisms.

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Different mean thickness implicates involvement of the cortex in migraine

Cited by 17 publications

References 33 publications

Altered structure of the vestibular cortex in patients with vestibular migraine

Altered structure of the vestibular cortex in patients with vestibular migraine

Differential Modulating Effect of Acupuncture in Patients With Migraine Without Aura: A Resting Functional Magnetic Resonance Study

Impaired intrinsic functional connectivity between the thalamus and visual cortex in migraine without aura

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