Different Kynurenine Pathway Dysregulation in Systemic Sclerosis in Men and Women
Monika Turska-Kozłowska,
Bruno Pedraz-Petrozzi,
Piotr Paluszkiewicz
et al.
Abstract:Systemic sclerosis (SSc), a predominantly female-affected systemic autoimmune disease, requires tailored treatment strategies contingent on organ involvement and symptom severity. Given SSc’s inflammatory nature, the involvement of the kynurenine pathway (KP) in its pathophysiology is underexplored. Our study aimed to investigate sex-related differences in KP activation among SSc patients and assess the impact of angiotensin-converting enzyme (ACE) inhibitors and estimated glomerular filtration rate (eGFR) on … Show more
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