Different involvement of ventral and dorsal norepinephrine pathways on norepinephrine reuptake inhibitor-induced locomotion and antidepressant-like effects in rats

Ku, Yu-Chi; Tsai, Ya-Ju; Tung, Che‐Se; Fang, Tien-Haw; Lo, Shih-Mao; Liu, Yia-Ping

doi:10.1016/j.neulet.2012.02.088

Cited by 6 publications

(3 citation statements)

References 31 publications

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“…Pharmacological studies have shown that CRF1 receptor antagonist, 5-HT1 receptor agonist, and adrenoreceptor antagonist can decrease depression-like behaviors, indicating that endogenous systems of CRF and monoamines including 5-HT and NE in the brain contribute to development of depression [31-34]. Thus, it is not unexpected that normalization of these systems attenuates depression-like behaviors [35-37]. In our study, mice subjected to forced swimming stress showed significant increases in brain expressions of CRF and NE, and significant decreases in brain expression of 5-HT.…”

Section: Discussionmentioning

confidence: 99%

Effect of the fragrance inhalation of essential oil from Asarum heterotropoides on depression-like behaviors in mice

Park

Lim²,

Zhao

et al. 2015

BMC Complement Altern Med

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BackgroundPsychological stressors may cause affective disorders, such as depression and anxiety, by altering expressions of corticotropin releasing factor (CRF), serotonin (5-HT), and tyrosine hydroxylase (TH) in the brain. This study investigated the effects of essential oil from Asarum heterotropoides (EOAH) on depression-like behaviors and brain expressions of CRF, 5-HT, and TH in mice challenged with stress.MethodsMale ICR mice received fragrance inhalation of EOAH (0.25, 0.5, 1.0, and 2.0 g) for 3 h in the special cage capped with a filter paper before start of the forced swimming test (FST) and tail suspension test (TST). The duration of immobility was measured for the determination of depression-like behavior in the FST and TST. The selective serotonin reuptake inhibitor fluoxetine as positive control was administered at a dose of 15 mg/kg (i.p.) 30 min before start of behavioral testing. Immunoreactivities of CRF, 5-HT, and TH in the brain were also measured using separate groups of mice subjected to the FST.ResultsEOAH at higher doses (1.0 and 2.0 g) reduced immobility time in the FST and TST. In addition, EOAH at a dose of 1.0 g significantly reduced the expected increases in the expression of CRF positive neurons in the paraventricular nucleus and the expression of TH positive neurons in the locus coeruleus, and the expected decreases of the 5-HT positive neurons in the dorsal raphe nucleus.ConclusionThese results provide strong evidence that EOAH effectively inhibits depression-like behavioral responses, brain CRF and TH expression increases, and brain 5-HT expression decreases in mice challenged with stress.

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Section: Discussionmentioning

confidence: 99%

Effect of the fragrance inhalation of essential oil from Asarum heterotropoides on depression-like behaviors in mice

Park

Lim²,

Zhao

et al. 2015

BMC Complement Altern Med

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“…Forced-swimming test (FST) was performed as described previously by our team [ 14 , 15 ], and was performed between 9:30 A.M. and 1:00 P.M. In brief, the rats were placed for 15 min into a 25 cm diameter × 50 cm height plastic cylinder, which was filled with 20–25°C water to a depth of 30 cm.…”

Section: Methodsmentioning

confidence: 99%

Effects of 5HT1A Activation on Depression Profile Following 5-HT Depletion in Rats Lacking Social Attachment Since Weanling

Chang

Chen

Chung

et al. 2018

Psychiatry Investig

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ObjectivePost weanling isolation-reared (IR) rats are featured with depressive phenotype, yet its mechanism is not clearly defined particularly in terms of the involvement of central 5-HT1A receptors. The present study aims to examine the effects of 5HT1A activation on forced swim test (FST) in IR rats following 5-HT depletion. MethodsSocial control (SOC) and IR rats received an intracerebraoventricular (ICV) injection of 5-HT depletion agent, 5,7-DHT. 14 days after the surgery, rats were assessed their performance in FST with or without the challenge with a 5-HT1A agonist, 8-OH-DPAT. Rats were then sacrificed for analyzing their 5-HT tissue levels and the expressions of their 5-HA1A receptors in prefrontal cortex (PFC), hippocampus (HPX), and amygdala (AMY). Results5,7-DHT decreased the tissue concentration of 5-HT in both IR and SOC rats. IR rats were more immobile and less sensitive to the lesion-induced immobility, however this effect was reversed by acute challenge of 8-OH-DPAT. 5,7-DHT lesion increased the expression of PFC 5-HT1A receptors. ConclusionThe integrity of central 5-HT system is developmentally crucial for the 5-HT1A-relevant depression profile in rats of social isolation.

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“…); morphine (1, 3 and 10 mg/kg) was injected subcutaneously (s.c.); and their vehicle (0.9% NaCl) was administered using the same respective routes. The doses and routes of injection were selected from previous reports showing that tapentadol and morphine significantly reduced nociceptive responses (Tzschentke et al., ; Kayser et al., ; Schiene et al., ) and reboxetine reduced thermal hyperalgesia (Pedersen et al., ) and induced antidepressant‐like effects (Wong et al., ; Ku et al., ) within the chosen dose ranges. Behavioural tests were performed at various times for up to 4 h after injection.…”

Section: Methodsmentioning

confidence: 99%

Effects of tapentadol on mechanical hypersensitivity in rats with ligatures of the infraorbital nerve versus the sciatic nerve

Michot

Bourgoin

Kayser

et al. 2012

European Journal of Pain

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Different involvement of ventral and dorsal norepinephrine pathways on norepinephrine reuptake inhibitor-induced locomotion and antidepressant-like effects in rats

Cited by 6 publications

References 31 publications

Effect of the fragrance inhalation of essential oil from Asarum heterotropoides on depression-like behaviors in mice

Effect of the fragrance inhalation of essential oil from Asarum heterotropoides on depression-like behaviors in mice

Effects of 5HT1A Activation on Depression Profile Following 5-HT Depletion in Rats Lacking Social Attachment Since Weanling

Effects of tapentadol on mechanical hypersensitivity in rats with ligatures of the infraorbital nerve versus the sciatic nerve

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