Different influence of polyoxygenation on the catalytic activity of amido- versus amino-isoborneols

Abstract

A new series of polyoxygenated amido-isoborneols has been synthesized and tested in the enantioselective addition of diethylzinc to benzaldehyde and the results compared to a series of related amino isoborneols. The observed different behavior is explained on the basis of catalytic chelates previously proposed by us.