Different incidence of prostate cancer according to metabolic health status: A nationwide cohort study

Transitions in metabolic syndrome and metabolic obesity status over time and risk of urologic cancer: A Prospective Cohort Study

“…Amongst MO phenotypes, MUO subjects had a 49% increased risk of UC at baseline than MHN subjects. A Korean study [21] showed that participants with metabolic unhealth obesity had a higher risk of prostate cancer as well. The results of MetS and MUO on promoting the development of UC can be explained as follows: On the one hand, they share many common risk factors, including older age, obesity, lack of exercise, unhealthy diet, disturbance of the biological clock, oxidative stress, air pollution and damage caused by exposure to substances that disrupt the endocrine system [22,23]; on the other hand, chronic in ammation determined by obesity may concur to the development of tumours, and insulin resistance may directly or indirectly enhance cell proliferation [24].…”