Different importance of the volatile and non-volatile fractions of an olfactory signature for individual social recognition in rats versus mice and short-term versus long-term memory

Noack, Julia; Richter, Karin; Laube, Gregor; Haghgoo, Hojjat Allah; Veh, Rüdiger W.; Engelmann, Mario

doi:10.1016/j.nlm.2010.09.013

Cited by 56 publications

(65 citation statements)

References 40 publications

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“…To protect the subject mice from previously noted muricide by rats (Noack et al 2010), we constructed a protective enclosure of wire mesh around the rat. The enclosure allowed for access to all four sides and the top of the rat.…”

Section: Social Memory For a Different Rodent Speciesmentioning

confidence: 99%

Importance of the GluN2B carboxy-terminal domain for enhancement of social memories

Jacobs

Wei²,

Wang³

et al. 2015

Learn. Mem.

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The N-methyl-D-aspartate (NMDA) receptor is known to be necessary for many forms of learning and memory, including social recognition memory. Additionally, the GluN2 subunits are known to modulate multiple forms of memory, with a high GluN2A:GluN2B ratio leading to impairments in long-term memory, while a low GluN2A:GluN2B ratio enhances some forms of long-term memory. Here, we investigate the molecular motif responsible for the differences in social recognition memory and olfactory memory in the forebrain-specific transgenic GluN2A overexpression mice and the forebrain-specific transgenic GluN2B overexpression mice by using two transgenic mouse lines that overexpress chimeric GluN2 subunits. The transgenic chimeric GluN2 subunit mice were tested for their ability to learn and remember fruit scents, male juveniles of the same strain, females of the same strain, male juveniles of another strain, and rodents of another species. The data presented here demonstrate that the GluN2B carboxy-terminal domain is necessary for enhanced social recognition memory in GluN2B transgenic overexpression mice. Furthermore, the GluN2A carboxy-terminal domain is responsible for the impaired long-term olfactory and social memory observed in the GluN2A overexpression mice.

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Section: Social Memory For a Different Rodent Speciesmentioning

confidence: 99%

Importance of the GluN2B carboxy-terminal domain for enhancement of social memories

Jacobs

Wei²,

Wang³

et al. 2015

Learn. Mem.

View full text Add to dashboard Cite

show abstract

“…The application of both enantiomers of carvone was previously performed in our lab. In that context we could show that (S)-(+)carvone triggers c-Fos synthesis in the main olfactory system [6] and R-(−)-carvone provided interference if used to additionally scenting the juvenile stimulus mice in the social discrimination test [15]. These observations made both enantiomers suitable to be tested as potentially interfering stimuli.…”

Section: Methodsmentioning

confidence: 84%

Timing of presentation and nature of stimuli determine retroactive interference with social recognition memory in mice

Camats-Perna

Wotjak

Stork

et al. 2015

Physiology & Behavior

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“…Our data from Tag1 +/− mice, where myelinated fibers are not affected in the hippocampus and other brain regions (Savvaki et al, 2008) but long-term social memory is altered, support the contribution of defective olfactory discrimination in this genotype. Noack et al (2010) showed that long-term social recognition in mice includes the neuronal activation of both the MOB and the AOB, contrary to rats, where the AOB is mainly activated. Furthermore, they showed that the non-volatile fraction (received by AOS) is sufficient for the formation of short-term social memory, whereas in the case of long-term social memory, both the volatile and non-volatile fractions are required.…”

Section: Discussionmentioning

confidence: 99%

TAG-1 deficiency results in olfactory dysfunction due to impaired migration of mitral cells

et al. 2015

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The olfactory system provides mammals with the abilities to investigate, communicate and interact with their environment. These functions are achieved through a finely organized circuit starting from the nasal cavity, passing through the olfactory bulb and ending in various cortical areas. We show that the absence of transient axonal glycoprotein-1 (Tag1)/contactin-2 (Cntn2) in mice results in a significant and selective defect in the number of the main projection neurons in the olfactory bulb, namely the mitral cells. A subpopulation of these projection neurons is reduced in Tag1-deficient mice as a result of impaired migration. We demonstrate that the detected alterations in the number of mitral cells are well correlated with diminished odor discrimination ability and social long-term memory formation. Reduced neuronal activation in the olfactory bulb and the corresponding olfactory cortex suggest that Tag1 is crucial for the olfactory circuit formation in mice. Our results underpin the significance of a numerical defect in the mitral cell layer in the processing and integration of odorant information and subsequently in animal behavior.

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Different importance of the volatile and non-volatile fractions of an olfactory signature for individual social recognition in rats versus mice and short-term versus long-term memory

Cited by 56 publications

References 40 publications

Importance of the GluN2B carboxy-terminal domain for enhancement of social memories

Importance of the GluN2B carboxy-terminal domain for enhancement of social memories

Timing of presentation and nature of stimuli determine retroactive interference with social recognition memory in mice

TAG-1 deficiency results in olfactory dysfunction due to impaired migration of mitral cells

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