Different implantable electrospun meshes for simultaneous application of prednisone and doxorubicin

Tóth, Krisztina; Fekete, Nóra; Simon, Vivien Klaudia; Tóth, Bence; Kovács, Árpád Ferenc; Pállinger, Éva; Antal, István; Kőhidai, László; Jedlovszky-Hajdú, Angéla; Juriga, Dávid; Nagy, Krisztina

doi:10.1016/j.molliq.2023.121854

Cited by 8 publications

(6 citation statements)

References 74 publications

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“…These solutions were used for fiber formation using the electrospinning technique. All the created polymer nets were white in color, and the added salt did not cause macroscopic changes as we also experienced in our previous works [ 21 , 35 ]. During sample preparation, a small adjustment was made to the experimental conditions shown in Table 1 .…”

Section: Resultssupporting

confidence: 66%

“…This value was even lower for the Zn(O 2 CCH 3 ) 2 -containing scaffold (0.05 ± 0.02 N·m 2 /g). Similarly, Tóth et al saw that drug loading decreased the specific maximum load capacity of the PSI polymer [ 35 ]. Pázmány et al also investigated a scaffold with 25% (w/w) PSI content, and they measured a lower specific maximum load capacity (0.08 ± 0.01 N·m 2 /g) compared to that of our results at the same concentration but at a higher average fiber diameter (590 ± 124 nm) [ 34 ].…”

Section: Resultsmentioning

confidence: 99%

“…According to their results, a growing concentration of prednisone in PSI and PCL polymers also increased the value of the initial modulus. In the case of poly(vinyl alcohol) (PVA), the initial modulus values decreased with increasing prednisone content [ 35 ]. We also observed that the presence of strontium salt significantly increased the Young’s modulus.…”

Section: Resultsmentioning

confidence: 99%

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Electrospun polysuccinimide scaffolds containing different salts as potential wound dressing material

Pálos,

Nagy,

Pázmány

et al. 2024

Beilstein J. Nanotechnol.

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In this research, we applied electrospinning to create a two-component biodegradable polymeric scaffold containing polysuccinimide (PSI) and antibacterial salts. Antibacterial agents for therapeutical purposes mostly contain silver ions which are associated with high environmental impact and, in some cases, may cause undesired immune reactions. In our work, we prepared nanofibrous systems containing antibacterial and tissue-regenerating salts of zinc acetate or strontium nitrate in different concentrations, whose structures may be suitable for developing biomedical wound dressing systems in the future. Several experiments have been conducted to optimize the physicochemical, mechanical, and biological properties of the scaffolds developed for application as wound dressings. The scaffold systems obtained by PSI synthesis, salt addition, and fiber formation were first investigated by scanning electron microscopy. In almost all cases, different salts caused a decrease in the fiber diameter of PSI polymer-based systems (<500 nm). Fourier-transform infrared spectroscopy was applied to verify the presence of salts in the scaffolds and to determine the interaction between the salt and the polymer. Another analysis, energy-dispersive X-ray spectroscopy, was carried out to determine strontium and zinc atoms in the scaffolds. Our result showed that the salts influence the mechanical properties of the polymer scaffold, both in terms of specific load capacity and relative elongation values. According to the dissolution experiments, the whole amount of strontium nitrate was dissolved from the scaffold in 8 h; however, only 50% of the zinc acetate was dissolved. In addition, antibacterial activity tests were performed with four different bacterial strains relevant to skin surface injuries, leading to the appearance of inhibition zones around the scaffold discs in most cases. We also investigated the potential cytotoxicity of the scaffolds on human tumorous and healthy cells. Except for the ones containing zinc acetate salt, the scaffolds are not cytotoxic to either tumor or healthy cells.

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Section: Resultssupporting

confidence: 66%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Electrospun polysuccinimide scaffolds containing different salts as potential wound dressing material

Pálos,

Nagy,

Pázmány

et al. 2024

Beilstein J. Nanotechnol.

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“…Differences in the structures of PSI, Alg, and Alg-PSI were determined using their X-ray diffraction (XRD) patterns, as shown in Figure 2F. No peaks for PSI are visible in the XRD pattern because PSI is an amorphous polymer [38]. XRD patterns of the Alg and Alg-PSI samples exhibited no significant differences.…”

Section: Synthesis and Characterization Of Alg-psimentioning

confidence: 99%

Development of Efficient Sodium Alginate/Polysuccinimide-Based Hydrogels as Biodegradable Acetaminophen Delivery Systems

Trinh,

Lim,

Lee

et al. 2023

Gels

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Efficient drug delivery systems are essential for improving patient outcomes. Acetaminophen (AP), which is a kind of oral administration, is a commonly used pain reliever and fever reducer. However, oral administration carries various health risks, especially overdose and frequent use; for instance, AP is administered approximately 4 times per day. Therefore, the aim of this study is to develop an efficient delivery system for once-daily administration by combining sodium alginate and polysuccinimide (PSI) hydrogels to delay the release of analgesic AP. PSI is a biodegradable polymer that can be used safely and effectively in drug delivery systems because it is eliminated by hydrolysis in the intestine. The use of PSI also improves the mechanical properties of hydrogels and prolongs drug release. In this study, hydrogel characterizations such as mechanical properties, drug dissolution ability, and biodegradability were measured to evaluate the hydrolysis of PSI in the intestine. Based on the results, hydrogels could be designed to improve the structural mechanical properties and to allow the drug to be completely dissolved, and eliminated from the body through PSI hydrolysis in the intestines. In addition, the release profiles of AP in the hydrogels were evaluated, and the hydrogels provided continuous release of AP for 24 h. Our research suggests that sodium alginate/PSI hydrogels can potentially serve as biodegradable delivery systems for AP. These findings may have significant implications for developing efficient drug delivery systems for other classes of drugs.

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“…These methods need to be chosen in accordance with the type of starting materials and manufacturing, which can be another aspect to divide biomaterials into the appropriate categories, as metal-based materials are generally not suitable for FTIR, fluorescent microscopy or generally in swelling or enzymatic decomposition related characterization, but their pathway or elimination can be followed in the living system for example, with magnetic resonance imaging (MRI), positron emission tomography (PET), computed tomography (CT). The manufacturing methods can mainly be divided into the following: phase separation (precipitation), rapid prototyping, supercritical fluid technology, porogen leaching, electrospinning, 3D printing, freeze drying, centrifugal casting, templating, and micro patterning (Collins and Birkinshaw, 2013;Tóth et al, 2023). However, generally the main requirement towards a biomaterial is to improve tissue regeneration and to enable to create an environment that supports the attachment, proliferation, migration and differentiation of cells (Juriga et al, 2022; Zhang et al).One of the biomaterials that have been in use for the longest time are metals, thus, it is safe to say that this type of materials made it through the test of time, however, we can still witness developmental directions, both in the manufacturing and in the treatment of metallic biomaterials.…”

mentioning

confidence: 99%

Editorial: Biomaterial applications in soft tissue engineering and replacement

Hornyák

Jedlovszky-Hajdú

Kehr

2023

Front. Bioeng. Biotechnol.

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Different implantable electrospun meshes for simultaneous application of prednisone and doxorubicin

Cited by 8 publications

References 74 publications

Electrospun polysuccinimide scaffolds containing different salts as potential wound dressing material

Electrospun polysuccinimide scaffolds containing different salts as potential wound dressing material

Development of Efficient Sodium Alginate/Polysuccinimide-Based Hydrogels as Biodegradable Acetaminophen Delivery Systems

Editorial: Biomaterial applications in soft tissue engineering and replacement

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