Different impacts of TP53 mutations on cell cycle-related gene expression among cancer types

Sasaki, Keiju; Takahashi, Shin; Ouchi, Kota; Otsuki, Yoshinori; Wakayama, Shonosuke; Ishioka, Chikashi

doi:10.1038/s41598-023-32092-8

Cited by 4 publications

(4 citation statements)

References 86 publications

(98 reference statements)

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“…In the light of the recent work by (73) this finding is in line with the HNSCC expression profile. The impact of TP53 mutations seems to be cancer type and possibly also genomic context dependent (73). It is important to note that the tumors without TP53 mutations also bore mutations in other cancer-related genes.…”

Section: Expression Of Tp53 Target Genes and Its Association To Patie...supporting

confidence: 80%

“…Interestingly, we did not find any significant association between TP53 mutations and mRNA expression of selected targets: BAX, PUMA, CDKN1A, and CDKN2A. In the light of the recent work by (73) this finding is in line with the HNSCC expression profile. The impact of TP53 mutations seems to be cancer type and possibly also genomic context dependent (73).…”

Section: Expression Of Tp53 Target Genes and Its Association To Patie...supporting

confidence: 66%

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Enhancing oral squamous cell carcinoma prediction: the prognostic power of the worst pattern of invasion and the limited impact of molecular resection margins

Hurník,

Režnarová,

Chyra

et al. 2023

Front. Oncol.

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ObjectiveOral squamous cell carcinoma (OSCC) originates from the mucosal lining of the oral cavity. Almost half of newly diagnosed cases are classified as advanced stage IV disease, which makes resection difficult. In this study, we investigated the pathological features and mutation profiles of tumor margins in OSCC.MethodsWe performed hierarchical clustering of principal components to identify distinct patterns of tumor growth and their association with patient prognosis. We also used next-generation sequencing to analyze somatic mutations in tumor and marginal tissue samples.ResultsOur analyses uncovered that the grade of worst pattern of invasion (WPOI) is strongly associated with depth of invasion and patient survival in multivariable analysis. Mutations were primarily detected in the DNA isolated from tumors, but several mutations were also identified in marginal tissue. In total, we uncovered 29 mutated genes, mainly tumor suppressor genes involved in DNA repair including BRCA genes; however none of these mutations significantly correlated with a higher chance of relapse in our medium-size cohort. Some resection margins that appeared histologically normal harbored tumorigenic mutations in TP53 and CDKN2A genes.ConclusionEven histologically normal margins may contain molecular alterations that are not detectable by conventional histopathological methods, but NCCN classification system still outperforms other methods in the prediction of the probability of disease relapse.

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Section: Expression Of Tp53 Target Genes and Its Association To Patie...supporting

confidence: 80%

Section: Expression Of Tp53 Target Genes and Its Association To Patie...supporting

confidence: 66%

Enhancing oral squamous cell carcinoma prediction: the prognostic power of the worst pattern of invasion and the limited impact of molecular resection margins

Hurník,

Režnarová,

Chyra

et al. 2023

Front. Oncol.

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“…MKI67, also known as proliferation marker Ki-67, is the subject of hundreds of papers chronicling its involvement in numerous kinds of cancer. For example, it correlates with TP53 mutation 51 . STAT1 is a known oncogene in many cancers including endometrial cancer 52 .…”

Section: Resultsmentioning

confidence: 99%

Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging

Bogdanowicz,

Bensadoun,

Noizet

et al. 2024

Sci Rep

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Intrinsic and extrinsic factors, including lifestyle and sun exposure, can contribute to cell senescence, which impairs skin homeostasis, that may in turn lead to skin aging. Senescent cells have a specific secretome, called the senescence-associated secretory phenotype (SASP) that includes MMPs, CXCLs and S100A8/9. Reducing the SASP with senotherapeutics is a promising strategy to reduce skin aging. Here we evaluated the effect of a formula containing niacinamide and hyaluronic acid, which are known to limit senescence and skin aging. We conducted three different studies. (1) Ex vivo explants treated with the formula had more collagen and glycosaminoglycan. (2) In a clinical trial with forty-four women, two months of treatment improved fine lines, wrinkles, luminosity, smoothness, homogeneity, and plumpness. (3) In a third study on thirty women, we treated one arm for two months and took skin biopsies to study gene expression. 101 mRNAs and 13 miRNAs were differentially expressed. We observed a likely senomorphic effect, as there was a decrease in many SASP genes including MMP12 and CXCL9 and a significant downregulation of autocrine signaling genes: S100A8 and S100A9. These pharmaco-clinical results are the first to demonstrate the senomorphic properties of an effective anti-aging formula in skin.

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“…Functional properties caused by Tumor Protein P53 (TP53) gene mutations are involved in cancer development and progression [45,46]. One of the most prevalent changes in the TP53 gene in human tumors is somatic mutation, while the underlying cause of Li-Fraumeni syndrome, which predisposes to a variety of early-onset cancers, is germline mutation.…”

Section: Discussionmentioning

confidence: 99%

DNA Promoter Methylation of the ATM, APC, CDO1, RB1, TP53, WIF1 Genes in Patients with Head and Neck Squamous Cell Carcinoma

Kurevlev,

Aghjanayan,

Tskhovrebova

et al. 2023

Preprint

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Head and neck squamous cell carcinoma (HNSCC) takes the sixth place among the most common cancers in the world. Abnormal methylation can be one of the reasons for this cancer. The aim of this study was to investigate the DNA promotor methylation status of cancer-associated genes (ATM, APC, CDO1, RB1, TP53, WIF1) in patients with HNSCC. Bisulfite Conversion and Methylation-Sensitive High-Resolution Melting was used for analysis of the DNA methylation level of normal and tumor tissues in 44 patients. There were significant differences in DNA methylation level between patient’s tumor and normal tissues for CDO1 and WIF1 genes in all subjects and subgroups (p<0.05). In T3 subgroup there was significant correlation between CDO1 gene methylation and age in the normal tissue. The same correlation was detected also for the WIF1 gene methylation in tumor tissue samples in the subgroup with T3 and in normal tissue samples in the subgroup with T4 (p<0,05). In all genes no significant differences were found between the subgroups (T2, T3, T4 stage, primary/recurrent lesion, non-keratinizing/keratinizing SCC, age before/ after 50, smokers/non-smokers) of the patients. Thus, changes in the expression of the CDO1 and WIF1 genes can affect mechanisms of the occurrence and development of HNSCC.

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Different impacts of TP53 mutations on cell cycle-related gene expression among cancer types

Cited by 4 publications

References 86 publications

Enhancing oral squamous cell carcinoma prediction: the prognostic power of the worst pattern of invasion and the limited impact of molecular resection margins

Enhancing oral squamous cell carcinoma prediction: the prognostic power of the worst pattern of invasion and the limited impact of molecular resection margins

Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging

DNA Promoter Methylation of the ATM, APC, CDO1, RB1, TP53, WIF1 Genes in Patients with Head and Neck Squamous Cell Carcinoma

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