Different Hypercoagulable Profiles in Patients with COVID-19 Admitted to the Internal Medicine Ward and the Intensive Care Unit

Abstract

Letter to the Editor 1474 This document was downloaded for personal use only. Unauthorized distribution is strictly prohibited.

Venous Thromboembolism in COVID-19

“…38 Point-ofcare analysis using viscoelastic methods (thromboelastography or rotational thromboelastometry) has been suggested as a rapidly available indicator of a hypercoagulable and/or hyperfibrinolytic state, especially in the ICU setting. [39][40][41] The clot formation time and the maximum clot firmness appeared to be particularly useful parameters and probably associated with elevated fibrinogen levels and in turn possibly with deposits of microthrombi in lung vessels. 40,41 It should be noted that the biological indicators can indicate thrombosis, but cannot predict hypercoagulability.…”

“…[39][40][41] The clot formation time and the maximum clot firmness appeared to be particularly useful parameters and probably associated with elevated fibrinogen levels and in turn possibly with deposits of microthrombi in lung vessels. 40,41 It should be noted that the biological indicators can indicate thrombosis, but cannot predict hypercoagulability. Ultrasound imaging can be used for monitoring and screening in combination with clinical signs and biological indicators of thrombosis, so as to enable early preventive anticoagulant therapy.…”

Positive end-expiratory pressure titration in COVID-19 acute respiratory failure: electrical impedance tomography vs. PEEP/FiO2 tables

“…To the Editor, Hypoxemic acute respiratory failure (hARF) secondary to COVID-19 presents with heterogeneous features depending on several determinants, such as the extent of intravascular microthrombosis, superinfections, and other complications [1,2]. The easiest approach for setting positive end-expiratory pressure (PEEP) and inspiratory oxygen fraction (FiO 2 ) is using PEEP/FiO 2 tables [3,4].…”

Plasma Antithrombin Values Are Significantly Decreased in Coronavirus Disease 2019 (COVID-19) Patients with Severe Illness

“…No inter-reviewer disagreement emerged. The final analysis thereby included six studies, [6][7][8][9][10][11] five cross-sectional and one prospective, totaling 471 COVID-19 patients, of whom 197 (41.8%) had severe disease (►Table 1). Three studies were performed in China, two in Italy, and one in France.…”