Different forms of the cobalt-bleomycin A2 complex

Nucleic Acid Recognition by Metal Complexes of Bleomycin

“…While likely of less direct therapeutic relevance, DNA cleavage by several other metallobleomycins has also been investigated. Among these, the Co complex of bleomycin is important as a model 18,19 of Fe(II)·bleomycin activation and structure due to its ability to bind bleomycin and O 2 to form a ternary complex − that appears to closely resemble oxygenated Fe(II)·bleomycin; aerobic oxidation of Co(II)·bleomycin in situ results in the formation of two Co(III)·bleomycin species: a peroxide complex, HOO−Co(III)·bleomycin, and Co(III)·bleomycin alone. , These metallobleomycins, designated Co(III)·bleomycin “green” and “brown”, respectively, are both capable of mediating DNA cleavage upon photoirradiation − with the former species being the more efficient of the two. Investigations of DNA cleavage by these complexes revealed the formation of alkali-labile sites, the release of free nucleobases, and DNA termini containing 3‘-phosphoroglycolates …”

Contributions of NMR to the Understanding of the Coordination Chemistry and DNA Interactions of Metallo-Bleomycins

“…Analysis of the oxidation products of Co(II)BLM by various scientists [36,37] led to the discovery of two BLM species denominated Form I (HOO-Co(III)BLM) and Form II (Co(III)BLM). Since their discovery, both MBLMs have been extensively studied.…”

Μελέτη Της Δομής Και Αλληλεπίδρασης Συμπλόκων Ενώσεων Του Αντικαρκινικού Φαρμάκου Μπλεομυκίνη Στο DNA Με Φασματοσκοπία Πυρηνικού Μαγνητικού Συντονισμού Και Προσομοιώσεις Μοριακής Δυναμικής

“…Τα σύμπλοκα του Co(ΙΙ) και Co(III) με μπλεομυκίνη, αν και δεν έχουν άμεσες θεραπευτικές ιδιότητες, μελετήθηκαν ως μοντέλα της δομής και ενεργοποίησης του Fe(II)-BLM [43,44], λόγω της ικανότητας τους να δεσμεύουν το O 2 σχηματίζοντας τριμερές σύμπλοκα παρόμοια με το οξυγονωμένο Fe(II)-BLM [54][55][56][57][58][59]. Αερόβια οξείδωση του [71] και Ni(III)-BLM [72].…”