Different faces of neurodegeneration

Abramov, Andrey Y.

doi:10.1111/febs.14646

The FEBS Journal

2018

DOI: 10.1111/febs.14646

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Different faces of neurodegeneration

Andrey Y. Abramov¹

Abstract: This Special Issue comprises nine reviews offering perspectives from the development of neurodegeneration in different pathologies to neuronal protection, providing new views on the mechanism of neurodegeneration and associated processes and a summary of the progress in neuroscience. We hope you find these reviews interesting and informative and we thank the authors for these excellent contributions to The FEBS Journal.

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“…). Our second Special Issue of the past year focused on ‘ Neurodegeneration’ and was edited by Andrey Abramov . Both of these issues contain many excellent and informative reviews and, if you have not done so already, I would strongly encourage you to browse the content of these issues.…”

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The FEBS Journal in 2019: ensuring that casks of vintage wine remain unspoiled

Martin

2019

The FEBS Journal

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mentioning

confidence: 99%

The FEBS Journal in 2019: ensuring that casks of vintage wine remain unspoiled

Martin

2019

The FEBS Journal

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Synthesis of Novel N-Acylhydrazones Derived from 3,5-Dinitrobenzohydrazide and Evaluation of Their Anticholinesterase and Antioxidant Activities

Çakmak,

Çınar,

Başaran

et al. 2024

Russ J Bioorg Chem

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Modulatory effect of simvastatin on redox status, caspase-3 expression, p-protein kinase B (p-Akt), and brain-derived neurotrophic factor (BDNF) in an ethanol-induced neurodegeneration model

Nasef

Keshk

Elmeligy

et al. 2021

Can. J. Physiol. Pharmacol.

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Neurodegenerative diseases are a common cause of morbidity and mortality worldwide with oxidative stress, inflammation and protein aggregation represent the main underlying mechanisms that ultimately lead to cell death. Ethanol has shown strong neurodegenerative consequences in experimental animal brains. Statins are a class of lipid-lowering drugs with many pleotropic effects. Therefore, the aim of the present study was to explore the modulatory effect of simvastatin (10 mg/kg/day) before and after the development of neurodegeneration (for 55 and 25 days, respectively) on redox state, caspase-3 expression, p-protein kinase B (p-Akt) and brain derived neurotrophic factor (BDNF) in ethanol (15% ethanol solution for 55 day) induced neurodegeneration. Seventy female Albino Swiss mice were included and randomly divided into 5 groups: control (c) group; ethanol (E) group; (ES) group treated with simvastatin from the first day of ethanol intake; (E+S) group treated with simvastatin after neurodegeneration development; and simvastatin (S) group. Administration of simvastatin from the first day improved the biochemical changes, suppressed apoptosis, induced autophagy and neurogenesis. However, its administration after the development of neurodegeneration resulted in partial improvement. The histopathological findings confirmed the biochemical changes. In conclusion; simvastatin has a neuroprotective effect against the development of ethanol-induced neurodegeneration and its progression.

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Different faces of neurodegeneration

Cited by 3 publications

References 14 publications

The FEBS Journal in 2019: ensuring that casks of vintage wine remain unspoiled

The FEBS Journal in 2019: ensuring that casks of vintage wine remain unspoiled

Synthesis of Novel N-Acylhydrazones Derived from 3,5-Dinitrobenzohydrazide and Evaluation of Their Anticholinesterase and Antioxidant Activities

Modulatory effect of simvastatin on redox status, caspase-3 expression, p-protein kinase B (p-Akt), and brain-derived neurotrophic factor (BDNF) in an ethanol-induced neurodegeneration model

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