Different expression patterns of mucin core proteins and cytokeratins during intrahepatic cholangiocarcinogenesis from biliary intraepithelial neoplasia and intraductal papillary neoplasm of the bile duct—an immunohistochemical study of 110 cases of hepatolithiasis

Zen, Yoh; Sasaki, Motoko; Fujii, Tozo; Chen, Tse–Ching; Chen, Miin‐Fu; Yeh, Ta‐Sen; Jan, Yi-Yin; Huang, Shiu-Feng; Nimura, Yuji; Nakanuma, Yasuni

doi:10.1016/j.jhep.2005.09.025

Cited by 229 publications

(230 citation statements)

References 20 publications

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“…Zen et al. also reported that nine cases of mucinous cholangiocarcinoma were detected in 110 cases of surgically resected hepatolithiasis,21 although these cases were not included in the present study because of insufficient clinical information.…”

Section: Discussionmentioning

confidence: 91%

“…described the characteristics of mucinous cholangiocarcinoma as rapid growth, widespread metastases, and poor prognosis, in comparison to the characteristics of IPNB. Conversely, Zen et al 21. reported mucinous cholangiocarcinoma as a less advanced tumor than conventional cholangiocarcinoma.…”

Section: Discussionmentioning

confidence: 97%

“…Mucinous cholangiocarcinoma is the rarest type of cholangiocellular carcinoma,12, 20 and this carcinoma is reported to be derived from IPNB 15, 16, 21. IPNB is pathologically characterized by prominent intraductal papillary proliferation with delicate fibrovascular cores and frequent mucin hypersecretion,15, 16, 21 and it is regarded as the biliary counterpart of intraductal papillary mucinous neoplasm of the pancreas.…”

Section: Discussionmentioning

confidence: 99%

“…IPNB is pathologically characterized by prominent intraductal papillary proliferation with delicate fibrovascular cores and frequent mucin hypersecretion,15, 16, 21 and it is regarded as the biliary counterpart of intraductal papillary mucinous neoplasm of the pancreas. When accompanied by invasive lesions, IPNB is known to be associated with conventional tubular adenocarcinoma or mucinous cholangiocarcinoma 22, 23, 24.…”

Section: Discussionmentioning

confidence: 99%

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Mucinous cholangiocarcinoma: Clinicopathological features of the rarest type of cholangiocarcinoma

Sumiyoshi¹,

Shima²,

Okabayashi³

et al. 2017

Annals of Gastroent Surgery

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Mucinous cholangiocarcinoma is extremely rare and its clinicopathological features remain unclear. The present study aimed to analyze published data on mucinous cholangiocarcinoma. Medical databases were searched from 1980 to 2016, and clinicopathological data for 16 mucinous cholangiocarcinoma patients were obtained. Characteristic imaging findings, including hypovascular tumor with peripheral enhancement on computed tomography and angiography, extremely high intensity on T2‐weighted magnetic resonance images, intratumoral calcification and luminal communication between the tumor and bile duct on cholangiography, were noted. Mucinous cholangiocarcinoma was correctly diagnosed in one patient only, with some patients diagnosed as low‐malignant biliary cystic tumors preoperatively. Five cases were followed up after the first medical examination, and three of these were initially diagnosed as biliary cystadenoma or intraductal papillary neoplasm of the bile duct. All five tumors showed marked enlargement within 4 months of follow up. Macroscopically, the resected tumors were non‐cystic/solid in seven cases, and cystic in seven. Tumor diameter ranged from 5 cm to 22 cm, and mucoid cut surface, lobulation, lack of capsule and papillary growth were observed. Microscopically, co‐existing intraductal papillary neoplasm of the bile duct was noted in three of five patients with available data. Nine of 10 cases in whom the pathological stage was reported had advanced disease with lymph node and/or distant metastasis, and 5‐year survival was achieved in one microinvasive case only. Overall 1‐ and 3‐year survival rates were 60.1% and 40.1%, respectively. The possibility of mucinous cholangiocarcinoma should be considered when biliary cystic tumors are detected on imaging modalities, despite the rarity of this tumor.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Mucinous cholangiocarcinoma: Clinicopathological features of the rarest type of cholangiocarcinoma

Sumiyoshi¹,

Shima²,

Okabayashi³

et al. 2017

Annals of Gastroent Surgery

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“…Recent studies have shed new light on cholangiocarcinomas with intraductal proliferative elements, including intraductal papillary neoplasm of the bile duct, [1][2][3][4][5][6] which was first documented by Nakanuma et al 7 and listed in the 2010 World Health Organization classification. 1 These tumors are mainly subdivided into two groups, with the intraductal growth type accounting for 6-14% of intrahepatic cholangiocarcinomas [8][9][10][11][12] and the macroscopic papillary growth type accounting for 8-20% of extrahepatic cholangiocarcinomas.…”

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confidence: 99%

Cholangiocarcinoma with intraductal tubular growth pattern versus intraductal papillary growth pattern

et al. 2016

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Intraductal neoplasms of the bile duct are macroscopically characterized by exophytic or polypoid growth patterns and have a favorable prognosis. Although some tumors with a predominantly tubular microscopic pattern have been reported, they have not been well characterized clinicopathologically. The purpose of the present study was to compare the newly recognized cholangiocarcinoma with an intraductal tubular growth pattern and cholangiocarcinoma with an intraductal papillary growth pattern and to investigate the pathological and prognostic significance of the former. This study analyzed 161 patients with tumors with exophytic or polypoid growth patterns from a large series of 733 cholangiocarcinoma cases surgically resected from January 1998 to May 2013. The study patients were divided into two groups: those whose tumors showed a predominantly tubular growth pattern (n = 52) and those whose tumors exhibited a predominantly papillary growth pattern (n = 109). Tubular growth pattern was associated with combined vascular resection and the absence of macroscopic mucin. Several histological indexes were significantly higher for the tubular growth pattern than the papillary one, including tubular adenocarcinoma, depth of invasion, microscopic lymphatic invasion, venous invasion, perineural invasion, and necrosis. Although the survival curves overlapped (P = 0.693), the rate of liver metastasis was significantly higher for the tubular growth pattern than for the papillary one (P = 0.012). Genomic DNA analysis focusing on somatic mutations in codons 12 and 13 of KRAS and codon 600 of BRAF revealed only one (4%) KRAS and no BRAF mutation among the 25 tubular cases examined. In conclusion, the tubular growth pattern exhibited differences in some histologic indexes, in addition to a higher hepatic metastasis rate and a lower KRAS mutation frequency, compared with the papillary growth pattern, but no difference in prognosis was observed. The distinctiveness of this tubular neoplasm should be further examined in the future.

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Should women with atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion, receive reflex human papillomavirus-DNA testing?

Liman

Giampoli

Bonfiglio

2005

Cancer

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Different expression patterns of mucin core proteins and cytokeratins during intrahepatic cholangiocarcinogenesis from biliary intraepithelial neoplasia and intraductal papillary neoplasm of the bile duct—an immunohistochemical study of 110 cases of hepatolithiasis

Cited by 229 publications

References 20 publications

Mucinous cholangiocarcinoma: Clinicopathological features of the rarest type of cholangiocarcinoma

Mucinous cholangiocarcinoma: Clinicopathological features of the rarest type of cholangiocarcinoma

Cholangiocarcinoma with intraductal tubular growth pattern versus intraductal papillary growth pattern

Should women with atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion, receive reflex human papillomavirus-DNA testing?

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