Different expression about induced sputum cell sorting in the two main types of chronic obstructive pulmonary disease

Song, Huifang; Cao, Yun; Xu, Mingqing; Sun, Dejun

doi:10.1002/dc.23818

Cited by 1 publication

(2 citation statements)

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“…Interestingly, in our study, we found that while changes in neutrophil counts were most closely associated with the cough score, a weekly increase in sputum eosinophils was associated with an increase in dyspnoea score, paralleled by an increase in rescue medications use. These findings expand upon previous observations showing that COPD patients with high sputum eosinophils are more likely to present with exertional dyspnoea, while patients with a neutrophilic phenotype more likely had chronic bronchitis . The mechanisms linking modifications of eosinophilic inflammation with the variability of dyspnoea in COPD are unexplored.…”

Section: Discussionsupporting

confidence: 82%

“…These findings expand upon previous observations showing that COPD patients with high sputum eosinophils are more likely to present with exertional dyspnoea, while patients with a neutrophilic phenotype more likely had chronic bronchitis. 25 The mechanisms linking modifications of eosinophilic inflammation with the variability of dyspnoea in COPD are unexplored. In asthma, the recruitment and activation of eosinophils led to the release of pro-inflammatory mediators with bronchoconstriction activity.…”

Section: Discussionmentioning

confidence: 99%

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Airway inflammatory profile is correlated with symptoms in stable COPD: A longitudinal proof‐of‐concept cohort study

et al. 2019

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Background and objective Symptoms negatively impact the quality of life and long‐term prognosis of patients with chronic obstructive pulmonary disease (COPD). Little is known about the relationship linking airway inflammation and symptoms in stable COPD. In this study, we evaluated whether respiratory symptoms in COPD are related to sputum inflammatory cellular profile and whether symptom changes are associated with changes in airway inflammation. Methods A total of 40 patients with stable COPD with moderate‐to‐severe airflow obstruction were enrolled. Patients were visited weekly over 4 weeks. At each visit, patients underwent clinical assessments, lung function tests and sputum induction. Patients recorded daily dyspnoea, sputum and cough scores. Results The changes between two consecutive visits in the percent of sputum neutrophils and eosinophils were related to the changes in the cough (P < 0.001; r = 0.63) and dyspnoea scores (P < 0.001; r = 0.58) of the prior week. Furthermore, using regression analyses, we were able to demonstrate that changes in the cough score were specifically associated to the change in neutrophils, while changes in the dyspnoea score and use of rescue medications were associated with changes in eosinophils numbers. Conclusion Our study showed an association between symptoms and the sputum inflammatory profile. In particular, changes in symptoms (cough and dyspnoea) were correlated with changes in the specific sputum inflammatory cell components of airway inflammation (neutrophils and eosinophils, respectively), providing novel information on the mechanisms of disease manifestation.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Airway inflammatory profile is correlated with symptoms in stable COPD: A longitudinal proof‐of‐concept cohort study

et al. 2019

View full text Add to dashboard Cite

show abstract

Different expression about induced sputum cell sorting in the two main types of chronic obstructive pulmonary disease

Abstract: These findings suggest that the morphological phenotypes of COPD show several clinical characteristics and different sputum cell sorting.

Cited by 1 publication

References 18 publications

Airway inflammatory profile is correlated with symptoms in stable COPD: A longitudinal proof‐of‐concept cohort study

Airway inflammatory profile is correlated with symptoms in stable COPD: A longitudinal proof‐of‐concept cohort study

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