Different effects of sodium bicarbonate and an alternate buffer (Carbicarb) in normal volunteers

Severe cutaneous side effects of peripheral infusions with carbicarb half strength

“…The most promising of these agents are Tris-buffer (THAM, 2-amino-2-hydroxymethyl-l,3propanediol), carbicarb (sodium bicarbonate 2.8% and disodium carbonate 3.6%, pH = 9.6) and dichloroacetate. The advantage of carbicarb should be avoiding an increase in PCO z [3,4,5].…”