Different effects of p53 protein overexpression on the survival of gastric cancer patients according to Lauren histologic classification: a retrospective study

Kim, Nayoung; Choi, Yonghoon; Kim, Won‐Seok; Yoon, Hyuk; Shin, Cheol Min; Park, Young Soo; Lee, Dong Hoon; Ahn, Sang Hoon; Park, Do Joong; Kim, Hyung‐Ho; Lee, Hye Seung; Kim, Ji Won; Kim, Jin Won; Lee, Moon Hyoung; Chang, Won; Park, Ji Hoon; Lee, Yoon Jin; Lee, Kyung Ho; Kim, Young Hoon

doi:10.1007/s10120-021-01163-y

Cited by 19 publications

(13 citation statements)

References 54 publications

(83 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The pattern of P53 overexpression also differed by sex; P53 overexpression was more frequent in males and intestinal-type GC patients. In our previous report on P53 overexpression, the clinical and prognostic significance differed by histological type of GC; P53 overexpression was more common in intestinal-type GC, but was associated with a poor prognosis for diffuse-type GC[ 18 ]. Therefore, it is also likely to act as a factor that affects GC prognosis differently in males and females.…”

Section: Discussionmentioning

confidence: 99%

Sex-based differences in histology, staging, and prognosis among 2983 gastric cancer surgery patients

Choi¹,

Kim²,

Jo³

et al. 2022

WJG

Self Cite

View full text Add to dashboard Cite

BACKGROUND Few studies have been conducted on sex differences in the incidence, pathophysiology, and prognosis of gastric cancer (GC). AIM To analyze the differences in GC characteristics according to sex in patients who underwent surgical treatment for GC. METHODS A total of 2983 patients diagnosed with gastric adenocarcinoma who received surgical treatment at the Seoul National University Bundang Hospital between 2003 and 2017 were included. Baseline clinicopathological characteristics, histologic type of GC, overall and GC-specific survival rates, and associated risk factors were analyzed. RESULTS Among the 2983 patients, 2005 (67.2%) and 978 (32.8%) were males and females, respectively. The average age of the female group (59.36 years) was significantly younger than that of the male group (61.66 years; P < 0.001). Cancer of the gastric body ( P < 0.001) and diffuse-type histology ( P < 0.001) were more common in females than in males. This trend was more prominent in females younger than 60 years of age, with a significantly higher proportion of diffuse-type cancer than in the male group. Regardless of sex, diffuse-type GC was more common in younger patients, and the proportion of intestinal-type GC increased with age. The overall survival rate was significantly higher in females ( P < 0.001). However, this difference disappeared for GC-specific survival ( P = 0.168), except for the poor GC-specific survival rate in advanced-stage cancer (stage III or above) in females ( P = 0.045). The risk factors for GC-related mortality were older age, upper location of GC, and diffuse- or mixed-type histology. In terms of comorbidities, more males died from diseases other than GC, including other malignancies such as lung cancer, hepatocellular carcinoma, and pancreatic cancer, and respiratory diseases such as interstitial lung disease and chronic obstructive pulmonary disease, while there were relatively more cardiovascular or cerebrovascular deaths in females. CONCLUSION Sex-based differences in GC were observed in clinicopathological features, including age at diagnosis, tumor location, histologic type, survival rate, and comorbidities.

show abstract

Section: Discussionmentioning

confidence: 99%

Sex-based differences in histology, staging, and prognosis among 2983 gastric cancer surgery patients

Choi¹,

Kim²,

Jo³

et al. 2022

WJG

Self Cite

View full text Add to dashboard Cite

show abstract

“…The homeostasis of the intestinal barrier is also disturbed by an imbalance that occurs between pro- and anti-apoptotic genes. In particular, it has been demonstrated that the p53 gene is involved in the initiation of the apoptosis mechanisms of the cellular cycle and its overexpression has been associated with different types of intestinal cancer [ 44 , 45 ]. Moreover, tumor suppressor p53 regulates the anti-apoptotic (Bcl2) and pro-apoptotic (Bax) members of the Bcl-2 proteins family, which control apoptosis by monitoring mitochondrial outer membrane permeabilization [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Transcriptional Changes after Enniatins A, A1, B and B1 Ingestion in Rat Stomach, Liver, Kidney and Lower Intestine

Cimbalo

Alonso-Garrido

Font

et al. 2021

Foods

View full text Add to dashboard Cite

Enniatins (ENs) are depsipeptide mycotoxins produced by Fusarium fungi. They are known for their capacity to modulate cell membrane permeability and disruption of ionic gradients, affecting cell homeostasis and initiating oxidative stress mechanisms. The effect of the acute toxicity of ENs A, A1, B and B1 at two different concentrations after 8 h of exposure was analysed in Wistar rats by a transcriptional approach. The following key mitochondrial and nuclear codified genes related to the electron transport chain were considered for gene expression analysis in stomach, liver, kidney and lower intestine by quantitative Real-Time PCR: mitochondrially encoded NADH dehydrogenase 1 (MT-ND1), mitochondrially encoded cytochrome c oxidase 1 (MT-COX1), succinate dehydrogenase flavoprotein subunit A and ATP synthase F1 subunit alpha, respectively. Moreover, the expression of markers involved in oxidative stresssuperoxide dismutase 1 (SOD1), glutathione peroxidase 1 (Gpx1), heme oxygenase 1, apoptosis B-cell lymphoma 2, Bcl2 Associated protein X (Bax), tumor suppressor protein (p53), inhibition of apoptosis nuclear factor kappa of activated B cells, immune system interleukin 1β and intestinal tight junction Occludin merely in lower intestine tissues have been investigated. For mitochondrial genes, the main differences were observed for MT-ND1 and MT-COX1, showing its deficiency in all selected organs. With regard to the intestinal barrier’s cellular response to oxidative stress, the activity of the antioxidant gene SOD1 was decreased in a dose-dependent manner. Similarly, the catalytic enzyme GPx1 was also downregulated though merely at medium dose employed. On the contrary, the pro-apoptotic Bax and p53 regulators were activated after ENs exposure, reporting a significant increase in their expression. Furthermore, the alteration of intestinal permeability was assessed by the abnormal activity of the tight junction protein occludin. In summary, ENs may generate mitochondrial disorders and induce oxidative stress in intestinal barrier function.

show abstract

“…We previously reported the effects of Helicobacter pylori eradication treatment, p53 overexpression, and incidence of metachronous GC in this cohort. 6 , 7 ) The following patients were excluded from the present study: those with incomplete medical records or unclassified histology, those who were lost to follow-up, those with a prior history of other cancers at the time of diagnosis, and those with other inoperable diseases. Finally, we included 2,983 patients in the analysis and classified them into three groups based on age: I (young, age <65 years, n=1,680), II (early old, age 60–74 years, n=919), and III (old, age ≥75 years, n=384) ( Fig.…”

Section: Methodsmentioning

confidence: 99%

Gastric Cancer in Older Patients: A Retrospective Study and Literature Review

Choi

Kim

et al. 2022

Ann Geriatr Med Res

Self Cite

View full text Add to dashboard Cite

Background: With increasing life expectancy, the incidence of gastric cancer (GC) in older adults is increasing. This study analyzed differences in GC characteristics according to age and sex among patients who underwent surgical treatment for GC.Methods: A total of 2,983 patients diagnosed with gastric adenocarcinoma who underwent surgical treatment at Seoul National University Bundang Hospital between 2003 and 2017 were classified into three groups: I (<65 years, n=1,680), II (60–74 years, n=919), and III (≥75 years, n=384). We compared the baseline clinical characteristics, pathological characteristics of the tumor, overall and GC-specific survival rates, and associated risk factors between the groups.Results: Cancer of the distal third of the stomach (p<0.001), with intestinal-type histology (p<0.001), and with p53 overexpression (p=0.004) were more common in groups II and III than in group I, and the proportion of intestinal-type GC increased with age. The cancer type, lymph node metastasis, and cancer stage did not differ significantly. In terms of overall survival, survival decreased with increasing age (p<0.001), but this difference decreased significantly for GC-specific survival. Cox multivariate analyses revealed age, histologic type (diffuse or mixed type), and advanced cancer stage (p=0.002, 0.001, and <0.001, respectively) as risk factors for GC-related mortalityConclusion: Age itself was found to be one of the most important prognostic factors for overall and disease-specific survival in elderly GC patients, along with cancer stage.

show abstract

Different effects of p53 protein overexpression on the survival of gastric cancer patients according to Lauren histologic classification: a retrospective study

Cited by 19 publications

References 54 publications

Sex-based differences in histology, staging, and prognosis among 2983 gastric cancer surgery patients

Sex-based differences in histology, staging, and prognosis among 2983 gastric cancer surgery patients

Transcriptional Changes after Enniatins A, A1, B and B1 Ingestion in Rat Stomach, Liver, Kidney and Lower Intestine

Gastric Cancer in Older Patients: A Retrospective Study and Literature Review

Contact Info

Product

Resources

About