1985
DOI: 10.1016/0306-3623(85)90069-2
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Different effects of local anesthetics on calcium influx into rat mast cells

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1988
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Cited by 9 publications
(4 citation statements)
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“…Thus, the effects of lidocaine on the histamine release induced by polycations are similar to that on the release induced by compound 48/ 80. One of the mechanisms for the inhibitory effect of lidocaine on histamine release in duced by Con A was due to inhibition of calcium influx into mast cells (14). However, lidocaine inhibits the histamine release in duced by calcium ionophore A23187 when there is enough intracellular calcium to trigger histamine releases, suggesting that their in hibitory actions on histamine release induced by A.23187 cannot be explained by their effect on calcium influx (14).…”
Section: Discussionmentioning
confidence: 99%
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“…Thus, the effects of lidocaine on the histamine release induced by polycations are similar to that on the release induced by compound 48/ 80. One of the mechanisms for the inhibitory effect of lidocaine on histamine release in duced by Con A was due to inhibition of calcium influx into mast cells (14). However, lidocaine inhibits the histamine release in duced by calcium ionophore A23187 when there is enough intracellular calcium to trigger histamine releases, suggesting that their in hibitory actions on histamine release induced by A.23187 cannot be explained by their effect on calcium influx (14).…”
Section: Discussionmentioning
confidence: 99%
“…One of the mechanisms for the inhibitory effect of lidocaine on histamine release in duced by Con A was due to inhibition of calcium influx into mast cells (14). However, lidocaine inhibits the histamine release in duced by calcium ionophore A23187 when there is enough intracellular calcium to trigger histamine releases, suggesting that their in hibitory actions on histamine release induced by A.23187 cannot be explained by their effect on calcium influx (14). Our group previously reported that the inhibitory effects of lidocaine on mast cells was correlated with the concen tration of nonionized molecules which pene trate the mast cell membrane (10).…”
Section: Discussionmentioning
confidence: 99%
“…The increase of [Ca 2ϩ ] i is an important response after cytokine stimulation. Lidocaine was reported to inhibit [Ca 2ϩ ] i accumulation and decrease calcium influx in mast cells (24). In this study, lidocaine inhibited MCP-1 stimulated calcium influx in THP-1 cells.…”
Section: Discussionmentioning
confidence: 87%
“…Similarly, Sasagawa et al [ 28 ] described the inhibitory effect of lidocaine on the chemotaxis of neutrophils. One of the proposed mechanisms that explain this effect is the inhibition by lidocaine of the accumulation of calcium and a subsequent decrease in the influx of this ion in mast cells [ 29 ]. This suggests that it is capable of suppressing the monocytic activation triggered by MCP-1 in the inflammatory process.…”
Section: Discussionmentioning
confidence: 99%