Different effects of cardiac resynchronization therapy on left atrial function in patients with either idiopathic or ischaemic dilated cardiomyopathy: a two-dimensional speckle strain study

D’Andrea, Antonello; Caso, Pio; Romano, Silvio; Scarafile, Raffaella; Riegler, Lucia; Salerno, Gemma; Limongelli, Giuseppe; Salvo, Giovanni Di; Calabrò, Paolo; Viscovo, Luca Del; Romano, Gianpaolo; Maiello, Ciro; Santangelo, L; Severino, Sergio; Cuomo, Sergio; Cotrufo, Maurizio; Calabrò, Raffaele

doi:10.1093/eurheartj/ehm443

Cited by 109 publications

(59 citation statements)

References 44 publications

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“…The development of new echocardiographic techniques, such as two-dimensional speckle tracking echocardiography (STE) has enhanced the ability to evaluate left atrial (LA) function by using quantitative assessment of myocardial deformation. Studies have indicated that STE is a feasible and reproducible method in assessing LA function (4,5). In some patient groups, as paroxysmal or permanent AF, LA strain measurements were found to be associated with episodes of paroxysmal AF and stroke risk in follow up (6,7).This method may provide a more direct evaluation of LA myocardial contractility and passive deformation (5).…”

Section: Introductionmentioning

confidence: 99%

Relation of presence and severity of metabolic syndrome with left atrial mechanics in patients without overt diabetes: a deformation imaging study

Kurt

Tanboğa²,

Büyükkaya³

et al. 2014

Anadolu Kardiyol Derg

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Objective: We aimed to investigate left atrium (LA) function by speckle tracking echocardiography in patients with metabolic syndrome (MetSyn) and to show a possible relationship between the severity of MetSyn and LA function and to determine the predictors of low strain in MetSyn patients. Methods: Our study design was observational and cross-sectional design consisted of 80 MetSyn patients without overt diabetes and 50 controls. The patients were classified into three groups based on the number of MetSyn criteria. The peak LA strain at the end of the ventricular systole (LAs-strain) as well as the LA strain with LA contraction (LAa-strain) was obtained. Correlation analysis performed to assess the association of LA strain parameters with the severity of MetSyn and logistic regression analysis performed to assess the relationship of low LA strain with MetSyn. Results: Both LAs (37.5±8.7 vs. 26.0±10.2, p<0.001) and LAa (19.9±6.3 vs. 13.0±6.4, p<0.001) strain measurements were found to be significantly decreased in patients with MetSyn when compared to the control group. Moreover, both LAs and LAa were found to be significantly decreased with the increasing severity of the MetSyn. A multiple logistic regression analysis demonstrated that the presence of MetSyn [OR:0.26 (95% CI 0.06-0.89), p=0.032] and left ventricular ejection fraction [OR:1.14 (95% CI 1.03-1.27), p=0.021] were independent predictors of LAs strain. Conclusion: MetSyn is associated with reduced LAs strain and LAa strain representing LA reservoir and pump function, respectively. Furthermore, LA mechanical function decreases even more with the increasing severity of the MetSyn.

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Section: Introductionmentioning

confidence: 99%

Relation of presence and severity of metabolic syndrome with left atrial mechanics in patients without overt diabetes: a deformation imaging study

Kurt

Tanboğa²,

Büyükkaya³

et al. 2014

Anadolu Kardiyol Derg

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“…The authors found that, compared with normal subjects, HCM patients had increased LA volume, decreased LA active emptying fraction, and decreased maximal slope of the time-volume curve during early diastole, suggesting that increased LV stiffness might contribute to the impairment of LA function [4]. In a study of 2-dimensional speckle tracking, moreover, the LA radial strain was shown to be reduced in patients with idiopathic compared with ischemic dilated cardiomyopathy [5]. Since there was a similar degree of the parameters of loading conditions such as mitral flow velocity profiles, it was suggested that LA involvement in the myocardial process might contribute to LA myocardial dysfunction in idiopathic cardiomyopathy patients [5].…”

Section: Echocardiographic Assessment Of La Function In Hcmmentioning

confidence: 99%

“…In a study of 2-dimensional speckle tracking, moreover, the LA radial strain was shown to be reduced in patients with idiopathic compared with ischemic dilated cardiomyopathy [5]. Since there was a similar degree of the parameters of loading conditions such as mitral flow velocity profiles, it was suggested that LA involvement in the myocardial process might contribute to LA myocardial dysfunction in idiopathic cardiomyopathy patients [5]. Only one study investigated regional LA function with strain or strain rate imaging in patients with HCM [6].…”

Section: Echocardiographic Assessment Of La Function In Hcmmentioning

confidence: 99%

“…Hypertrophic cardiomyopathy (HCM) has an extremely hypertrophied LV and is commonly associated with LA enlargement and dysfunction [1,2]. Numerous echocardiographic studies have investigated LA function in patients with a variety of heart diseases [1][2][3][4][5][6][7][8]. In patients with HCM, it is generally accepted that increased LA volume is associated with a higher incidence of LV diastolic dysfunction and cardiac events and more severe LV hypertrophy [2,4].…”

Section: Introductionmentioning

confidence: 99%

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Left Atrial Dyssynchrony in Patients With Nonobstructive Hypertrophic Cardiomyopathy Evaluated by Myocardial Strain Imaging

et al. 2008

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Background. The present study was conducted to examine left atrial (LA) dyssynchrony, determined by echocardiographic myocardial strain imaging, in patients with hypertrophic cardiomyopathy (HCM). Methods.We studied 26 patients with HCM (20 men and 6 women, age, 66 7 years) and 25 normal subjects (controls). Tissue Doppler-based strain images were recorded in the apical 2-, 4-chamber, and long-axis views. The LA strain curve was obtained with the region of interest placed at the 5 LA segments, namely, the atrial septum, lateral wall, inferior wall, anterior wall, and posterior wall. We measured standard deviation (SD) of the time-periods between aortic valve opening and maximal strain (reservoir dyssynchrony index) and SD of the time-periods between mitral valve opening and minimal strain (emptying dyssynchrony index). (40 23 Conclusions. LA dyssynchrony can be present throughout the cardiac cycle in patients with HCM. LA dyssynchrony is more common in the reservoir phase and may be attributed to significant myocardial involvement. (J Echocardiogr 2008; 6: 46-53) Results. Compared with controls, patients with HCM had greater indexes of reservoir

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“…Most studies assessing 2DS strain and SR in disease states measured ε total -i.e., LA reservoir function and not contractile function. D'Andrea et al [92,93•] studied patients with dilated cardiomyopathy and found that ε total and active LAEF were depressed in both idiopathic and ischemic cardiomyopathy compared to controls, but more [92]. In a study of diastolic dysfunction with invasive hemodynamic correlates, ε total strongly correlated with LV end-diastolic pressure and LV end-systolic volume [94].…”

Section: Speckle Trackingmentioning

confidence: 99%

Left Atrial Function: Doppler and Strain

Klein

2010

Curr Cardiovasc Imaging Rep

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The left atrium modulates left ventricular filling with its reservoir, conduit, and contractile functions. There is growing literature on the importance of a detailed assessment of left atrial function. This review article discusses the echocardiographic assessment of left atrial function by conventional parameters such as atrial size measurements, transmitral and pulmonary Doppler flow, mitral annular tissue velocities, as well as newer techniques such as regional strain and strain rate imaging by color tissue Doppler imaging and two-dimensional speckle tracking techniques. The clinical applications of these techniques in various conditions are discussed.

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Different effects of cardiac resynchronization therapy on left atrial function in patients with either idiopathic or ischaemic dilated cardiomyopathy: a two-dimensional speckle strain study

Cited by 109 publications

References 44 publications

Relation of presence and severity of metabolic syndrome with left atrial mechanics in patients without overt diabetes: a deformation imaging study

Relation of presence and severity of metabolic syndrome with left atrial mechanics in patients without overt diabetes: a deformation imaging study

Left Atrial Dyssynchrony in Patients With Nonobstructive Hypertrophic Cardiomyopathy Evaluated by Myocardial Strain Imaging

Left Atrial Function: Doppler and Strain

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